Griseofulvin

Name: Griseofulvin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

13 interactions

Also sold as: Fulvicin P/G Fulvicin P/G® Fulvicin-U/F® Grifulvin V® Gris-PEG Gris-PEG® Grisactin® Ultragris®

About Griseofulvin

Griseofulvin is used to treat skin infections such as jock itch, athlete's foot, and ringworm; and fungal infections of the scalp, fingernails, and toenails. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Read the full Griseofulvin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Estradiol Estradiol Topical Estradiol Transdermal Patch Levonorgestrel Levonorgestrel Intrauterine System

11 Major 2 Moderate

All (13) Major (11) Moderate (2)

Major

Griseofulvin Azathioprine Azasan An increased risk of hepatotoxicity Details Griseofulvin Estradiol Delestrogen Decreased contraceptive effectiveness Details Griseofulvin Estradiol Topical Divigel Decreased contraceptive effectiveness Details Griseofulvin Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Griseofulvin Levonorgestrel After banger Decreased contraceptive effectiveness Details Griseofulvin Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Griseofulvin Medroxyprogesterone Amen® Decreased contraceptive effectiveness Details Griseofulvin Medroxyprogesterone Injection Depo-Provera Decreased contraceptive effectiveness Details Griseofulvin Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Griseofulvin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Griseofulvin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Griseofulvin Cyclosporine Injection Atopica Decreased cycloSPORINE effectiveness Details Griseofulvin Cyclosporine Ophthalmic Cequa Decreased cycloSPORINE effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.