Ponatinib

Name: Ponatinib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

10 interactions 1 explained in plain English

Also sold as: Iclusig Iclusig®

About Ponatinib

Ponatinib is used to treat certain types of chronic myeloid leukemia (CML; a type of cancer of the white blood cells), including treatment in people who can no longer benefit from other medications for CML or who cannot take these medications because of side effects. Ponatinib is also used to treat certain types of acu… Read the full Ponatinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical

1 Major 1 Moderate 8 Minor

All (10) Major (1) Moderate (1) Minor (8)

Moderate

Ponatinib Levothyroxine Ermeza Increased risk of hypothyroidism Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.