Valproic Acid

35 interactions 2 explained in plain English

Also sold as: Depakene® Depakote® Depakote® ER Depakote® Sprinkle

About Valproic Acid

Valproic acid is an anticonvulsant used to treat seizures, mania in bipolar disorder, and prevent migraine headaches. Read the full Valproic Acid drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Apixaban Methotrexate Injection Meropenem Injection Estradiol Transdermal Patch Hydroxychloroquine Felbamate

26 Major 9 Moderate

All (35) Major (26) Moderate (9)

Major

Valproic Acid Apixaban Eliquis Explained Decreased apixaban exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Valproic Acid Aspirin Acuprin® Increased valproic acid exposure Details Valproic Acid Aspirin Rectal Aspirin Increased valproic acid exposure Details Valproic Acid Azathioprine Azasan An increased risk of hepatotoxicity Details Valproic Acid Calcifediol Rayaldee Altered serum levels of calcifediol Details Valproic Acid Cisplatin Injection Platinol-AQ® Decreased valproic acid plasma concentrations and increased risk of seizures Details Valproic Acid Dabigatran Pradaxa® Decreased dabigatran exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Valproic Acid Dabigatran Etexilate Decreased dabigatran exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Valproic Acid Doripenem Injection Doribax® Reduced valproic acid exposure and increased risk for breakthrough seizures Details Valproic Acid Edoxaban Savaysa Decreased edoxaban exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Valproic Acid Ertapenem Injection Invanz Reduced valproic acid exposure and increased risk of seizures and status epilepticus Details Valproic Acid Estradiol Delestrogen Decreased valproate exposure and increased risk of seizures Details Valproic Acid Estradiol Topical Divigel Decreased valproate exposure and increased risk of seizures Details Valproic Acid Estradiol Transdermal Patch Alora® Decreased valproate exposure and increased risk of seizures Details Valproic Acid Ethosuximide Zarontin An increased risk of ethosuximide toxicity Details Valproic Acid Felbamate Felbatol Increased valproic acid exposure Details Valproic Acid Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Valproic Acid Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Valproic Acid Meloxicam Injection Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Valproic Acid Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Valproic Acid Meropenem Reduced valproic acid exposure and an increased risk of seizures and status epilepticus Details Valproic Acid Meropenem Injection Merrem® Reduced valproic acid exposure and an increased risk of seizures and status epilepticus Details Valproic Acid Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Valproic Acid Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Valproic Acid Nifedipine Adalat® Increased NIFEdipine exposure Details Valproic Acid Orlistat Alli Reduced efficacy of anticonvulsant Details

Moderate

Valproic Acid Amitriptyline Elavil Explained Increased amitriptyline exposure Details Valproic Acid Acyclovir Avaclyr Decreased valproic acid plasma concentrations and potential increased seizure activity Details Valproic Acid Acyclovir Injection Avaclyr Decreased valproic acid plasma concentrations and potential increased seizure activity Details Valproic Acid Acyclovir Ophthalmic Avaclyr Decreased valproic acid plasma concentrations and potential increased seizure activity Details Valproic Acid Acyclovir Topical Zovirax Decreased valproic acid plasma concentrations and potential increased seizure activity Details Valproic Acid Cholestyramine Resin Locholest® Decreased serum valproic acid concentrations Details Valproic Acid Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Valproic Acid Mefloquine Lariam® Loss of seizure control Details Valproic Acid Nimodipine Nimotop Nimodipine toxicity (dizziness, headache, flushing, peripheral edema) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.