Vandetanib

74 interactions 6 explained in plain English
Also sold as: Caprelsa Caprelsa®
About Vandetanib

Vandetanib is used to treat a certain type of thyroid cancer that cannot be treated by surgery or that has spread to other parts of the body. Vandetanib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or… Read the full Vandetanib drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Colchicine Ivabradine Oxaliplatin Injection Hydroxychloroquine Amisulpride Injection
2 Contraindicated 71 Major 1 Moderate
All (74) Contraindicated (2) Major (71) Moderate (1)

Contraindicated

Vandetanib Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Vandetanib Ketoconazole Topical Extina® Foam Increased vandetanib exposure and an increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

Major

Vandetanib Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Vandetanib Sertraline Explained An increased risk of QT interval prolongation Details Vandetanib Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Vandetanib Relugolix Orgovyx Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Vandetanib Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Vandetanib Apixaban Eliquis Explained Increased apixaban exposure Details Vandetanib Arsenic Trioxide Trisenox An increased risk of QT interval prolongation and Torsades de pointes Details Vandetanib Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Vandetanib Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation and Torsades de pointes Details Vandetanib Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation and torsades de pointes Details Vandetanib Azithromycin AzaSite Increased risk of QT interval prolongation Details Vandetanib Alfuzosin UroXatral An increased risk of QT interval prolongation Details Vandetanib Anagrelide Agrylin Increased risk of QT-interval prolongation Details Vandetanib Bedaquiline Sirturo Increased risk of QT interval prolongation Details Vandetanib Chloroquine Aralen® An increased risk of QT interval prolongation and Torsades de pointes Details Vandetanib Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Vandetanib Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Vandetanib Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Vandetanib Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Vandetanib Dasatinib Phyrago An increased risk of QT interval prolongation Details Vandetanib Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Vandetanib Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Vandetanib Digoxin Cardoxin® Increased digoxin exposure Details Vandetanib Disopyramide Norpace An increased risk of QT interval prolongation and Torsades de pointes Details Vandetanib Dofetilide Tikosyn An increased risk of QT interval prolongation and Torsades de pointes Details Vandetanib Dolasetron Anzemet An increased risk of QT interval prolongation and Torsades de pointes Details Vandetanib Dolasetron Injection Anzemet An increased risk of QT interval prolongation and Torsades de pointes Details Vandetanib Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Vandetanib Edoxaban Savaysa Increased edoxaban exposure Details Vandetanib Encorafenib Braftovi Increased risk of QT interval prolongation Details Vandetanib Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Vandetanib Eribulin Injection Halaven Increased risk of QT-interval prolongation Details Vandetanib Famotidine Calmicid Increased risk of QT-interval prolongation Details Vandetanib Famotidine Injection Calmicid Increased risk of QT-interval prolongation Details Vandetanib Felbamate Felbatol Increased risk of QT-interval prolongation Details Vandetanib Flecainide Tambocor® An increased risk of QT interval prolongation and Torsades de pointes Details Vandetanib Foscarnet Injection Foscavir Increased risk of QT-interval prolongation Details Vandetanib Fostemsavir Rukobia Increased risk of torsade de pointes Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.