Zolpidem

39 interactions 4 explained in plain English
Also sold as: Ambien Edluar Zolpimist
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Zolpidem Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Zolpidem Abametapir Explained Increased exposure of CYP3A4 substrate Details Zolpidem Sertraline Explained Increased zolpidem exposure Details Zolpidem Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Zolpidem Aripiprazole Injection Abilify An increased risk of CNS depression, complex sleep behaviors and respiratory depression Details Zolpidem Asenapine Transdermal Patch Secuado An increased risk of CNS depression, complex sleep behaviors and respiratory depression Details Zolpidem Azathioprine Azasan An increased risk of hepatotoxicity Details Zolpidem Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Zolpidem Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Zolpidem Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Zolpidem Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Zolpidem Cyclosporine Injection Atopica Increased zolpidem exposure Details Zolpidem Cyclosporine Ophthalmic Cequa Increased zolpidem exposure Details Zolpidem Dexamethasone Injection Decadron Reduced zolpidem exposure Details Zolpidem Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced zolpidem exposure Details Zolpidem Diazepam Nasal Spray Valtoco An increased risk of CNS depression, complex sleep behaviors and respiratory depression Details Zolpidem Diazepam Rectal Diastat An increased risk of CNS depression, complex sleep behaviors and respiratory depression Details Zolpidem Diphenhydramine Injection Banophen An increased risk of CNS depression, complex sleep behaviors and respiratory depression Details Zolpidem Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression, complex sleep behaviors and respiratory depression Details Zolpidem Esketamine Nasal Spray Spravato Increased risk of sedation Details Zolpidem Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Zolpidem Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Zolpidem Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Zolpidem Ketoconazole Topical Extina® Foam Increased zolpidem exposure Details Zolpidem Lacosamide Injection Motpoly An increased risk of CNS depression Details Zolpidem Letermovir Injection Prevymis Increased zolpidem exposure Details Zolpidem Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Zolpidem Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Zolpidem Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Zolpidem Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Zolpidem Metoclopramide Injection Gimoti Increased risk of CNS depression Details Zolpidem Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Zolpidem Midazolam Nasal Spray Nayzilam An increased risk of CNS depression, complex sleep behaviors and respiratory depression Details Zolpidem Midazolam Injection Nayzilam An increased risk of CNS depression, complex sleep behaviors and respiratory depression Details Zolpidem Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Zolpidem Nafcillin Injection Unipen® Injection Reduced zolpidem exposure Details Zolpidem Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Zolpidem Nevirapine Viramune Reduced zolpidem exposure Details

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