Drug & supplement interaction

Atractylodes + Binimetinib

Binimetinib brand name: Mektovi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Atractylodes and Binimetinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Atractylodes and Binimetinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Binimetinib and Atractylodes in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Atractylodes safety at a glance

Atractylodes overall Use caution Often used traditionally, but human safety data are limited, so use cautiously and under guidance.
Pregnancy Possibly Unsafe When used orally. In animals, atractylodes has caused reproductive toxicity, including fetal death, as well as changes in gestation, growth, and skeletal format... Read the full pregnancy detail
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid it to be safe.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Binimetinib and Atractylodes? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Binimetinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Binimetinib is filed under 2 classifications — hepatotoxic drugs, oral drugs. Atractylodes has documented interactions with 5 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), aromatase inhibitors (moderate) and hexobarbital (moderate) — and none of Binimetinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Atractylodes Does Interact With Other Medications

Atractylodes has 127 moderate, 674 minor known drug interactions in our database — Binimetinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 127 Minor 674 No known interaction 2,029 (incl. Binimetinib)
Taking anything else?

Check Another of Your Medications Against Atractylodes

Covers the 2,830 medications we’ve checked against Atractylodes. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Atractylodes and Binimetinib May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea reported in 9.2% of FDA reports for Binimetinib Additional detail

    Atractylodes

    “Orally, atractylenolide I, an isolated constituent of atractylodes, can cause bad taste, nausea, and dry mouth.”

    Atractylodes · Natural Medicines adverse-effect record, reported in dry mouth.

    1 source cited
    1. 15706. Liu Y, Jia Z, Dong L, et al. A randomized pilot study of atractylenolide I on gastric cancer cachexia patients. Evid Based Complement Alternat Med 2008;5:337-44. PubMed

    Binimetinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Binimetinib, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Atractylodes but not commonly for Binimetinib: an allergic reaction and dry mouth.

Effects for Binimetinib come from the ADVERSE REACTIONS section of its FDA label; effects for Atractylodes come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 7,756 voluntary FDA FAERS reports for Binimetinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Atractylodes in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. In animals, atractylodes has caused reproductive toxicity, including fetal death, as well as changes in gestation, growth, and skeletal formation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Binimetinib Is Prescribed For, and What Atractylodes Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Binimetinib is a prescription medicine with approved uses on its FDA label. Atractylodes is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Binimetinib is prescribed for: Mektovi (binimetinib) is used in combination with another medicine called encorafenib. Together, they treat unresectable (cannot be surgically removed) or metastatic (spread to other parts of the body) melanoma in patients whose tumors have a BRAF V600E or V600K mutation, as confirmed by an FDA-approved test. Mektovi, used with encorafenib, is also approved for adult patients with metastatic non-small cell lung cancer (NSCLC) that carries a BRAF V600E mutation, again confirmed by an FDA-approved test. In both cases, testing for the specific mutation is required before starting treatment.

Atractylodes has been studied for:

  • Lung cancer studied, not established Atractylodes has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Atractylodes for lung cancer

    Although there has been interest in using oral atractylodes for lung cancer, there is insufficient reliable information about the clinical effects of atractylodes for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Binimetinib on your own; if you are taking Atractylodes for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Atractylodes or Binimetinib

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Atractylodes or Binimetinib, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Binimetinib

This page covers Atractylodes only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Binimetinib page lists 55 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 42 moderate · 9 minor.

From our pharmacist’s overview on the Binimetinib page

“Binimetinib (Mektovi) is a targeted cancer drug for melanoma, and this list warrants genuine care before you mix in supplements. Of the 55 herbal and supplement ingredients on file, 38 share one core problem: they can stress the liver, and layering them onto a medication your liver is already processing raises the risk of real damage.”

Reviewed by 2 · Jul 18, 2026

Open the Binimetinib interaction page

One more smart check

Taking Atractylodes as Part of a Dietary Supplement Product? Check It for Interactions

We hold 691 real supplement products containing Atractylodes, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Atractylodes. Even though Atractylodes itself has no known interaction with Binimetinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Atractylodes and Binimetinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Atractylodes
Top 25%

#241 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Binimetinib
Steady interest

#2,119 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Atractylodes reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Atractylodes and Binimetinib records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Atractylodes

What is Atractylodes?

Atractylodes
  • Digestive upset and poor appetite
  • Bloating and fluid retention
  • General fatigue or 'weakness'
  • Diarrhea
  • Support within traditional formulas

Atractylodes is a root used for centuries in traditional Chinese, Japanese, and Thai medicine, mostly for digestive complaints and fatigue, often as part of multi-herb formulas. Modern research is still early and mostly from lab and animal studies, so its true benefits in people are not well proven. If you want to try it, talk with a pharmacist or doctor first, and avoid it during pregnancy and breastfeeding.

Atractylodes macrocephala; Atractylodes lancea · Asteraceae · Rhizome (root) · Dried root, powders, capsules, decoctions (teas), and part of traditional Chinese and Japanese herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Atractylodes is a good idea for someone in your situation. Here is what our Atractylodes record says about it on its own.

Atractylodes: dosing

There is no well-established standard dose for Atractylodes as a single supplement, and traditional amounts vary depending on the formula and the form used (dried root, powder, capsule, or decoction).If you choose to use it, follow the directions on the product label and do not exceed the suggested amount.

From our Atractylodes monograph — the full record covers uses, side effects and every documented interaction.

Read the full Atractylodes monograph & all interactions
Medication

About Binimetinib

What Is Binimetinib Used For?

Brand name: Mektovi

Mektovi (binimetinib) is used in combination with another medicine called encorafenib. Together, they treat unresectable (cannot be surgically removed) or metastatic (spread to other parts of the body) melanoma in patients whose tumors have a BRAF V600E or V600K mutation, as confirmed by an FDA-approved test.

Mektovi, used with encorafenib, is also approved for adult patients with metastatic non-small cell lung cancer (NSCLC) that carries a BRAF V600E mutation, again confirmed by an FDA-approved test. In both cases, testing for the specific mutation is required before starting treatment.

Most-Reported Side Effects for Binimetinib

From FAERS, the FDA’s public side-effect reporting system (7,756 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 715 reports
Fatigue 604 reports
Diarrhea 570 reports
Fever 542 reports
Vomiting 415 reports
See full Binimetinib drug information
Keep checking

Other Drugs & Atractylodes

Browse every other medication we’ve checked against Atractylodes — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
127Moderate
674Minor
2,028No known interaction
127 Moderate 674 Minor 2,028 No interaction
Moderate

127 interactions

Showing 60 of 127 moderate interactions — see all 127 on the Atractylodes page.

Minor

674 interactions

Showing 60 of 674 minor interactions — see all 674 on the Atractylodes page.

No interaction 2,028 drugs checked — show the list

We also checked Atractylodes against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,028 medications checked with no known interaction — see the full Atractylodes list.

See the full Atractylodes interactions page
See every supplement checked against Binimetinib, ranked by severity
Evidence & sources

Atractylodes References

The 6 references that drive our Atractylodes monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Liu Y, Jia Z, Dong L, et al. A randomized pilot study of atractylenolide I on gastric cancer cachexia patients. Evid Based Complement Alternat Med 2008;5:337-44. PubMed
  2. Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017 Mar;28(2):194-202. PubMed
  3. Jiang H, Shi J, Li Y. Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz. Molecules. 2011 Apr 14;16(4):3146-51. PubMed
  4. Koonrungsesomboon N, Na-Bangchang K, Karbwang J. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med. 2014 Jun;7(6):421-8. PubMed
  5. Li L, Tang LY, Man GC, Yeung BH, Lau CB, Leung PC, Wang CC. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Hum Reprod. 2011 Dec;26(12):3280-8. PubMed
  6. Muhamad N, Plengsuriyakarn T, Na-Bangchang K. Atractylodes lancea for cholangiocarcinoma: Modulatory effects on CYP1A2 and CYP3A1 and pharmacokinetics in rats and biodistribution in mice. PLoS One 2022;17(11):e0277614. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Atractylodes and Binimetinib Together: Common Questions

Is it safe to take Atractylodes with Binimetinib?
We do not list a known interaction between Atractylodes and Binimetinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Atractylodes and Binimetinib have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Atractylodes and Binimetinib used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Atractylodes in each. That is a conversation for your prescriber, especially if Binimetinib is being adjusted to a target.
How was the Atractylodes and Binimetinib combination checked?
Interactions in our licensed database are recorded against drug classes. Binimetinib is filed under 2 classifications, and Atractylodes has documented interactions with 5 drug classes — none of Binimetinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Atractylodes interact with any other medications?
Yes. Atractylodes has 801 documented drug interactions in our database — Binimetinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Binimetinib interact with any supplements?
Yes. Binimetinib has documented interactions with 55 supplements in our database — Atractylodes is not one of them. The Binimetinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Atractylodes monograph Uses, safety profile, and every drug interaction in one place Binimetinib drug information The full plain-English guide to this medication Binimetinib supplement interactions Every supplement checked against Binimetinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Binimetinib and Atractylodes?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.