Drug & supplement interaction

Atractylodes + Valsartan

Valsartan brand names: Diovan, Prexxartan.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Atractylodes and Valsartan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Atractylodes and Valsartan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Valsartan and Atractylodes in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Atractylodes safety at a glance

Atractylodes overall Use caution Often used traditionally, but human safety data are limited, so use cautiously and under guidance.
Pregnancy Possibly Unsafe When used orally. In animals, atractylodes has caused reproductive toxicity, including fetal death, as well as changes in gestation, growth, and skeletal format... Read the full pregnancy detail
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid it to be safe.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Valsartan and Atractylodes? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Valsartan

Interactions in our licensed database are recorded against drug classes, not just single drug names. Valsartan is filed under 4 classifications — including angiotensin receptor blockers (arbs), cytochrome p450 2c9 (cyp2c9) substrates, antihypertensive drugs. Atractylodes has documented interactions with 5 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), aromatase inhibitors (moderate) and hexobarbital (moderate) — and none of Valsartan’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Atractylodes Does Interact With Other Medications

Atractylodes has 127 moderate, 674 minor known drug interactions in our database — Valsartan isn’t one of them. If you take anything else, check it against the full list below.

Moderate 127 Minor 674 No known interaction 2,029 (incl. Valsartan)
Taking anything else?

Check Another of Your Medications Against Atractylodes

Covers the 2,830 medications we’ve checked against Atractylodes. Pick one to open its full report.

What to actually watch for

What Atractylodes Itself Has Been Linked To

This is not an interaction — nothing below involves Valsartan. It is the side-effect record for Atractylodes on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Atractylodes, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    “There is currently a limited amount of information on the adverse effects of atractylodes. A thorough evaluation of safety outcomes has not been conducted.

    Most Common Adverse Effects:

    Orally: Allergic reaction, dry mouth, nausea.”

    Atractylodes · Natural Medicines adverse-effect record, reported in dry mouth.

  • Dry mouth / Nausea Additional detail

    “Orally, atractylenolide I, an isolated constituent of atractylodes, can cause bad taste, nausea, and dry mouth.”

    Atractylodes · Natural Medicines adverse-effect record, reported in dry mouth.

    1 source cited
    1. 15706. Liu Y, Jia Z, Dong L, et al. A randomized pilot study of atractylenolide I on gastric cancer cachexia patients. Evid Based Complement Alternat Med 2008;5:337-44. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Atractylodes — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Valsartan’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Valsartan column appears here.

Special populations

Atractylodes in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. In animals, atractylodes has caused reproductive toxicity, including fetal death, as well as changes in gestation, growth, and skeletal formation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Atractylodes or Valsartan

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Atractylodes or Valsartan, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Valsartan

This page covers Atractylodes only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Valsartan page lists 182 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 145 moderate · 33 minor.

From our pharmacist’s overview on the Valsartan page

“Of the 182 supplements and herbs on file for valsartan (Diovan), a medication for high blood pressure and heart failure, most either deepen its blood-pressure-lowering effect or work against it, and the four rated major deserve genuine respect before the rest of the page. Activated charcoal can cut the absorption of oral doses, and the…”

Reviewed by 2 · Jul 18, 2026

Open the Valsartan interaction page

One more smart check

Taking Atractylodes as Part of a Dietary Supplement Product? Check It for Interactions

We hold 691 real supplement products containing Atractylodes, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Atractylodes. Even though Atractylodes itself has no known interaction with Valsartan, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Atractylodes and Valsartan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Atractylodes
Top 25%

#228 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Valsartan
Top 5%

#110 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Atractylodes reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Atractylodes and Valsartan records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Atractylodes

What is Atractylodes?

Atractylodes
  • Digestive upset and poor appetite
  • Bloating and fluid retention
  • General fatigue or 'weakness'
  • Diarrhea
  • Support within traditional formulas

Atractylodes is a root used for centuries in traditional Chinese, Japanese, and Thai medicine, mostly for digestive complaints and fatigue, often as part of multi-herb formulas. Modern research is still early and mostly from lab and animal studies, so its true benefits in people are not well proven. If you want to try it, talk with a pharmacist or doctor first, and avoid it during pregnancy and breastfeeding.

Atractylodes macrocephala; Atractylodes lancea · Asteraceae · Rhizome (root) · Dried root, powders, capsules, decoctions (teas), and part of traditional Chinese and Japanese herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Atractylodes is a good idea for someone in your situation. Here is what our Atractylodes record says about it on its own.

Atractylodes: dosing

There is no well-established standard dose for Atractylodes as a single supplement, and traditional amounts vary depending on the formula and the form used (dried root, powder, capsule, or decoction).If you choose to use it, follow the directions on the product label and do not exceed the suggested amount.

From our Atractylodes monograph — the full record covers uses, side effects and every documented interaction.

Read the full Atractylodes monograph & all interactions
Medication

About Valsartan

What Is Valsartan Used For?

Brand names: Diovan, Prexxartan

Valsartan is used to treat high blood pressure (hypertension) in adults and children, heart failure in adults, and to lower the risk of cardiovascular death in adults who have had a heart attack and have reduced heart function. Lowering blood pressure reduces the risk of stroke and heart attack.

Diovan (valsartan) tablets are approved to treat high blood pressure in children as young as 1 year old. Valsartan tablets (generic) are approved for children 6 years and older. Valsartan oral solution is specifically indicated for patients with heart failure or post-heart attack left ventricular dysfunction who are unable to swallow tablets.

See full Valsartan drug information
Keep checking

Other Drugs & Atractylodes

Browse every other medication we’ve checked against Atractylodes — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
127Moderate
674Minor
2,028No known interaction
127 Moderate 674 Minor 2,028 No interaction
Moderate

127 interactions

Showing 60 of 127 moderate interactions — see all 127 on the Atractylodes page.

Minor

674 interactions

Showing 60 of 674 minor interactions — see all 674 on the Atractylodes page.

No interaction 2,028 drugs checked — show the list

We also checked Atractylodes against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,028 medications checked with no known interaction — see the full Atractylodes list.

See the full Atractylodes interactions page
See every supplement checked against Valsartan, ranked by severity
Evidence & sources

Atractylodes References

The 6 references that drive our Atractylodes monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Liu Y, Jia Z, Dong L, et al. A randomized pilot study of atractylenolide I on gastric cancer cachexia patients. Evid Based Complement Alternat Med 2008;5:337-44. PubMed
  2. Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017 Mar;28(2):194-202. PubMed
  3. Jiang H, Shi J, Li Y. Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz. Molecules. 2011 Apr 14;16(4):3146-51. PubMed
  4. Koonrungsesomboon N, Na-Bangchang K, Karbwang J. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med. 2014 Jun;7(6):421-8. PubMed
  5. Li L, Tang LY, Man GC, Yeung BH, Lau CB, Leung PC, Wang CC. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Hum Reprod. 2011 Dec;26(12):3280-8. PubMed
  6. Muhamad N, Plengsuriyakarn T, Na-Bangchang K. Atractylodes lancea for cholangiocarcinoma: Modulatory effects on CYP1A2 and CYP3A1 and pharmacokinetics in rats and biodistribution in mice. PLoS One 2022;17(11):e0277614. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Atractylodes and Valsartan Together: Common Questions

Is it safe to take Atractylodes with Valsartan?
We do not list a known interaction between Atractylodes and Valsartan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Atractylodes and Valsartan combination checked?
Interactions in our licensed database are recorded against drug classes. Valsartan is filed under 4 classifications, and Atractylodes has documented interactions with 5 drug classes — none of Valsartan's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Atractylodes interact with any other medications?
Yes. Atractylodes has 801 documented drug interactions in our database — Valsartan is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Valsartan interact with any supplements?
Yes. Valsartan has documented interactions with 182 supplements in our database — Atractylodes is not one of them. The Valsartan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Atractylodes monograph Uses, safety profile, and every drug interaction in one place Valsartan drug information The full plain-English guide to this medication Valsartan supplement interactions Every supplement checked against Valsartan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Valsartan and Atractylodes?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.