Beta-methylphenethylamine (bmpea) + Acetaminophen, Caffeine, Dihydrocodeine
Acetaminophen, Caffeine, Dihydrocodeine brand names: Panlor DC, Panlor SS, DHC Plus.
Acetaminophen, Caffeine, Dihydrocodeine falls into 3 drug categories that Beta-methylphenethylamine (bmpea) can interact with; the most serious is rated moderate. Theoretically, BMPEA might increase the levels and clinical effects of CYP2D6 substrates.
Read the full interaction reportBeta-methylphenethylamine (bmpea) and Acetaminophen, Caffeine, Dihydrocodeine
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Beta-methylphenethylamine (bmpea) interacts with whole categories of medication. Acetaminophen, Caffeine, Dihydrocodeine falls into 3 of those categories, so it can interact with Beta-methylphenethylamine (bmpea) in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
1 of 3Why this applies to Acetaminophen, Caffeine, Dihydrocodeine
Acetaminophen, Caffeine, Dihydrocodeine falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Beta-methylphenethylamine (bmpea) interacts with.
In vitro research shows that BMPEA strongly inhibits CYP2D6.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the wrinkle with this combo product. The dihydrocodeine part is a prodrug, meaning your body has to convert it using an enzyme called CYP2D6 to turn it into its stronger painkilling form. Lab studies suggest BMPEA blocks that very enzyme. So in theory, less of your dihydrocodeine would get switched on, and you might get weaker pain relief than expected.
I'll be honest, this is theoretical and based only on test-tube data, so I don't want to alarm you. But there's a bigger picture: BMPEA is an amphetamine-like stimulant, and stacking it with a product that also has caffeine can push up your heart rate and blood pressure. I'd skip BMPEA and check with your pharmacist or doctor first.
- Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
2 of 3Acetaminophen, Caffeine, Dihydrocodeine also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
In vitro research shows that BMPEA inhibits CYP3A4 by up to 37%.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing about this combo product: it carries two real concerns. First, BMPEA is itself a stimulant similar to amphetamine, and your tablet already contains caffeine. Stacking two stimulants can leave you jittery, with a racing heart or higher blood pressure. That's the part I'd worry about most in everyday life.
Second, lab studies suggest BMPEA may mildly block CYP3A4, an enzyme that helps process the dihydrocodeine piece. This is only theoretical from test-tube data, but if it slowed clearance, you could see stronger opioid effects like extra drowsiness, dizziness, or constipation. Honestly, since BMPEA isn't a proven or approved ingredient, I'd steer clear of it and check with your pharmacist before mixing.
- Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
STIMULANT DRUGS
3 of 3Acetaminophen, Caffeine, Dihydrocodeine also falls under STIMULANT DRUGS.
BMPEA is thought to have stimulant effects, including cardiovascular effects such as hypertension, tachycardia, and cardiac arrest.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to know about your Panlor or DHC Plus product: it contains caffeine, which is itself a mild stimulant. BMPEA is a synthetic compound chemically close to amphetamine, so it can also rev up your system, pushing up heart rate and blood pressure. Stack a stimulant supplement on top of the caffeine in this combo and you may double up on that stimulating effect.
In real terms, that could mean a racing or pounding heartbeat, jitteriness, trouble sleeping, or higher blood pressure. I'll be honest, this concern is theoretical and based on how these ingredients act, not on solid human studies. Even so, BMPEA isn't an approved or well-studied ingredient and regulators have flagged it for heart risks, so I'd steer clear and check with your pharmacist or doctor first.
- Cohen PA, Bloszies C, Yee C, Gerona R. An amphetamine isomer whose efficacy and safety in humans has never been studied, ß-methylphenylethylamine (BMPEA), is found in multiple dietary supplements. Drug Test Anal. 2015 Apr 7. PubMed
- Brown DH, Hansson R, Oosthuizen F, et al. ß-Methylphenylethylamines: common fragmentation pathways with amphetamines in electrospray ionization collision-induced dissociation. Drug Test Anal 2016;8:344-50.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Beta-methylphenethylamine (bmpea) Also Interacts With Other Medications
Beta-methylphenethylamine (bmpea) has 812 moderate known drug interactions in our database — the Acetaminophen, Caffeine, Dihydrocodeine one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Beta-methylphenethylamine (bmpea)
We haven’t checked that one against Beta-methylphenethylamine (bmpea) yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Beta-methylphenethylamine (bmpea). Pick one to open its full report.
See Every Supplement That Interacts With Acetaminophen, Caffeine, Dihydrocodeine
This page covers Beta-methylphenethylamine (bmpea) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Caffeine, Dihydrocodeine page lists 303 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Ephedra (major).
By severity: 15 major · 244 moderate · 44 minor.
From our pharmacist’s overview on the Acetaminophen, Caffeine, Dihydrocodeine page
“Anything else that sedates you is the headline risk with this combination painkiller. Panlor and DHC Plus pair acetaminophen and caffeine with the opioid dihydrocodeine, and 78 of the 303 supplements on file, kava and even beer or wine among them, can deepen the opioid's drowsiness and, at the extreme, dangerously slow breathing.”
Reviewed by 2 · Jul 18, 2026
Open the Acetaminophen, Caffeine, Dihydrocodeine interaction page
Where Beta-methylphenethylamine (bmpea) and Acetaminophen, Caffeine, Dihydrocodeine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#795 of 1,452 supplements looked up here in the last 7 days
#126 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Beta-methylphenethylamine (bmpea)
What is Beta-methylphenethylamine (bmpea)?
- Weight loss
- Pre-workout energy
- Athletic performance
- Appetite suppression
- Mental focus
Beta-methylphenethylamine (BMPEA) is a synthetic stimulant chemically similar to amphetamine that has been found in some weight-loss and sports supplements, often without being clearly listed on the label. It is not an approved or well-studied dietary ingredient, and regulators have warned that it may carry real cardiovascular risks. Because of safety concerns and the lack of human research, it is best avoided.
Other Drugs & Beta-methylphenethylamine (bmpea)
Browse every other medication we’ve checked against Beta-methylphenethylamine (bmpea) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
812 interactions
- Diltiazem ›
- Nifedipine ›
- Phentermine ›
- Hydrocortisone ›
- Methylphenidate ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Phenylpropanolamine ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Nicotine ›
- Oxybutynin ›
- Oxycodone ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Miconazole ›
- Morphine Sulfate ›
- Phenylephrine ›
- Pseudoephedrine ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Diethylpropion ›
- Everolimus ›
- Ivabradine ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Nortriptyline ›
- Propoxyphene ›
- Rifampin ›
- Testosterone Undecanoate ›
- Aripiprazole ›
- Caffeine (otc Drug) ›
- Ciclesonide ›
- Clonazepam ›
- Cyclobenzaprine ›
- Dapsone ›
- Desipramine ›
Showing 60 of 812 moderate interactions — see all 812 on the Beta-methylphenethylamine (bmpea) page.
No interaction 2,017 drugs checked — show the list
We also checked Beta-methylphenethylamine (bmpea) against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Ivermectin ›
- Acetaminophen ›
- Aspirin ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Semaglutide ›
- Metformin ›
- Isotretinoin ›
- Amoxicillin ›
- Methotrexate ›
- Lisinopril ›
- Bendamustine ›
- Bupropion ›
- Doxycycline ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Gabapentin ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Methylene Blue ›
- Ciprofloxacin ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Acetaminophen, Aspirin ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Cyclopentolate ›
- Cephalexin ›
- Ezetimibe ›
- Acetylsalicylic Acid ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Mannitol ›
- Roxithromycin ›
- Levetiracetam ›
- Phentermine, Topiramate ›
- Spironolactone ›
- Levodopa ›
- Levothyroxine Sodium ›
- Valsartan ›
- Pizotifen ›
- Acetaminophen, Ibuprofen ›
- Mitomycin ›
- Canagliflozin, Metformin ›
- Daptomycin ›
- Atenolol ›
- Insulin Degludec, Liraglutide ›
- Cefaclor ›
- Magnesium Hydroxide (otc Drug) ›
- Pegunigalsidase Alfa-iwxj ›
- Hexobarbitone ›
- Acarbose ›
Showing the 60 most looked-up of 2,017 medications checked with no known interaction — see the full Beta-methylphenethylamine (bmpea) list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Acetaminophen, Caffeine, Dihydrocodeine Is Linked to Lower Levels of 2 Nutrients
Natural Medicines records Acetaminophen, Caffeine, Dihydrocodeine as a medicine that can lower these. This is not an interaction with Beta-methylphenethylamine (bmpea) — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Acetaminophen, Caffeine, Dihydrocodeine nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Beta-methylphenethylamine (bmpea) and Acetaminophen, Caffeine, Dihydrocodeine Together: Common Questions
Can you take Beta-methylphenethylamine (bmpea) with Acetaminophen, Caffeine, Dihydrocodeine?
Why are there 3 interactions listed for Beta-methylphenethylamine (bmpea) and Acetaminophen, Caffeine, Dihydrocodeine?
How serious is the Beta-methylphenethylamine (bmpea) and Acetaminophen, Caffeine, Dihydrocodeine interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.