Beta-methylphenethylamine (bmpea) + Dextromethorphan, Pseudoephedrine, Triprolidine
Dextromethorphan, Pseudoephedrine, Triprolidine brand name: Actifed DM.
Dextromethorphan, Pseudoephedrine, Triprolidine falls into 3 drug categories that Beta-methylphenethylamine (bmpea) can interact with; the most serious is rated moderate. Theoretically, BMPEA might increase the levels and clinical effects of CYP2D6 substrates.
Read the full interaction reportBeta-methylphenethylamine (bmpea) and Dextromethorphan, Pseudoephedrine, Triprolidine
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Beta-methylphenethylamine (bmpea) interacts with whole categories of medication. Dextromethorphan, Pseudoephedrine, Triprolidine falls into 3 of those categories, so it can interact with Beta-methylphenethylamine (bmpea) in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
1 of 3Why this applies to Dextromethorphan, Pseudoephedrine, Triprolidine
Dextromethorphan, Pseudoephedrine, Triprolidine falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Beta-methylphenethylamine (bmpea) interacts with.
In vitro research shows that BMPEA strongly inhibits CYP2D6.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to know about Actifed DM: one of its ingredients, dextromethorphan (the cough suppressant), is cleared from your body by a liver enzyme called CYP2D6. Lab studies suggest BMPEA can strongly block that enzyme. If it does, dextromethorphan could build up and hit you harder, leading to more drowsiness, dizziness, confusion, or in higher amounts, a jittery, agitated feeling.
On top of that, BMPEA is an amphetamine-like stimulant, and so is the pseudoephedrine in this product. Stacking two stimulants can push your heart rate and blood pressure up. Honestly, BMPEA is best avoided altogether since it's unapproved and poorly studied. This particular interaction is theoretical, but please run it past your pharmacist or doctor before combining them.
- Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
2 of 3Dextromethorphan, Pseudoephedrine, Triprolidine also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
In vitro research shows that BMPEA inhibits CYP3A4 by up to 37%.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to keep in mind with Actifed DM (which combines dextromethorphan, pseudoephedrine, and triprolidine). In lab studies, BMPEA appears to mildly block an enzyme called CYP3A4, which helps your body clear part of this combo, especially the dextromethorphan. If that enzyme slows down, those medicine levels could creep up, possibly leading to more drowsiness, dizziness, or jitteriness.
The bigger concern, though, is that BMPEA is an amphetamine-like stimulant, and pseudoephedrine is also a stimulant. Stacking them could push your heart rate and blood pressure higher. Honestly, BMPEA is best avoided altogether. The enzyme part is only theoretical, but please run this by your pharmacist before combining them.
- Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
STIMULANT DRUGS
3 of 3Dextromethorphan, Pseudoephedrine, Triprolidine also falls under STIMULANT DRUGS.
BMPEA is thought to have stimulant effects, including cardiovascular effects such as hypertension, tachycardia, and cardiac arrest.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to watch with Actifed DM: one of its ingredients, pseudoephedrine, is itself a stimulant decongestant. It can already nudge your heart rate up and raise your blood pressure on its own. BMPEA is chemically a cousin of amphetamine and is also thought to act as a stimulant, so stacking the two could pile those effects on top of each other.
In real terms, that might mean a racing or pounding heartbeat, jitteriness, trouble sleeping, or a spike in blood pressure. This concern is theoretical, based on how these compounds behave rather than solid human studies, so I'm not trying to alarm you. Still, BMPEA isn't a well-vetted ingredient, and I'd rather you check with your pharmacist or doctor before combining them.
- Cohen PA, Bloszies C, Yee C, Gerona R. An amphetamine isomer whose efficacy and safety in humans has never been studied, ß-methylphenylethylamine (BMPEA), is found in multiple dietary supplements. Drug Test Anal. 2015 Apr 7. PubMed
- Brown DH, Hansson R, Oosthuizen F, et al. ß-Methylphenylethylamines: common fragmentation pathways with amphetamines in electrospray ionization collision-induced dissociation. Drug Test Anal 2016;8:344-50.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Beta-methylphenethylamine (bmpea) Also Interacts With Other Medications
Beta-methylphenethylamine (bmpea) has 812 moderate known drug interactions in our database — the Dextromethorphan, Pseudoephedrine, Triprolidine one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Beta-methylphenethylamine (bmpea)
We haven’t checked that one against Beta-methylphenethylamine (bmpea) yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Beta-methylphenethylamine (bmpea). Pick one to open its full report.
See Every Supplement That Interacts With Dextromethorphan, Pseudoephedrine, Triprolidine
This page covers Beta-methylphenethylamine (bmpea) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextromethorphan, Pseudoephedrine, Triprolidine page lists 198 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Lithium (major) and Peyote (major).
By severity: 8 major · 149 moderate · 41 minor.
From our pharmacist’s overview on the Dextromethorphan, Pseudoephedrine, Triprolidine page
“Actifed DM pairs a stimulant decongestant (pseudoephedrine) with a cough suppressant that acts on serotonin (dextromethorphan), which is why I want you reading this list with real care before adding any supplement. Eight of the 198 flagged ingredients rate major.”
Reviewed by 2 · Jul 18, 2026
Open the Dextromethorphan, Pseudoephedrine, Triprolidine interaction page
Where Beta-methylphenethylamine (bmpea) and Dextromethorphan, Pseudoephedrine, Triprolidine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,235 of 1,452 supplements looked up here in the last 7 days
#2,763 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Beta-methylphenethylamine (bmpea)
What is Beta-methylphenethylamine (bmpea)?
- Weight loss
- Pre-workout energy
- Athletic performance
- Appetite suppression
- Mental focus
Beta-methylphenethylamine (BMPEA) is a synthetic stimulant chemically similar to amphetamine that has been found in some weight-loss and sports supplements, often without being clearly listed on the label. It is not an approved or well-studied dietary ingredient, and regulators have warned that it may carry real cardiovascular risks. Because of safety concerns and the lack of human research, it is best avoided.
Other Drugs & Beta-methylphenethylamine (bmpea)
Browse every other medication we’ve checked against Beta-methylphenethylamine (bmpea) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
812 interactions
- Diltiazem ›
- Nifedipine ›
- Phentermine ›
- Hydrocortisone ›
- Methylphenidate ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Phenylpropanolamine ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Nicotine ›
- Oxybutynin ›
- Oxycodone ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Miconazole ›
- Morphine Sulfate ›
- Phenylephrine ›
- Pseudoephedrine ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Diethylpropion ›
- Everolimus ›
- Ivabradine ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Nortriptyline ›
- Propoxyphene ›
- Rifampin ›
- Testosterone Undecanoate ›
- Aripiprazole ›
- Caffeine (otc Drug) ›
- Ciclesonide ›
- Clonazepam ›
- Cyclobenzaprine ›
- Dapsone ›
- Desipramine ›
Showing 60 of 812 moderate interactions — see all 812 on the Beta-methylphenethylamine (bmpea) page.
No interaction 2,017 drugs checked — show the list
We also checked Beta-methylphenethylamine (bmpea) against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Ivermectin ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Valacyclovir ›
- Ibuprofen ›
- Tirzepatide ›
- Hydroxyurea ›
- Semaglutide ›
- Sumatriptan ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Methotrexate ›
- Bendamustine ›
- Acyclovir ›
- Doxycycline ›
- Pregabalin ›
- Lamotrigine ›
- Azithromycin ›
- Isotretinoin ›
- Gabapentin ›
- Methylene Blue ›
- Naproxen ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Cyclopentolate ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Mannitol ›
- Roxithromycin ›
- Levetiracetam ›
- Pegunigalsidase Alfa-iwxj ›
- Ezetimibe ›
- Amoxicillin, Clavulanate Potassium ›
- Levothyroxine Sodium ›
- Daptomycin ›
- Spironolactone ›
- Phentermine, Topiramate ›
- Valsartan ›
- Mitomycin ›
- Thyroid Hormone ›
- Acetaminophen, Aspirin ›
- Acetaminophen, Ibuprofen ›
- Hexobarbitone ›
- Carbidopa, Levodopa ›
- Factor 7a ›
- Levodopa ›
- Lenvatinib ›
- Minoxidil ›
- Azelaic Acid ›
- Cefaclor ›
- Ibuprofen, Acetaminophen ›
- Acetylsalicylic Acid ›
- Tenecteplase ›
Showing the 60 most looked-up of 2,017 medications checked with no known interaction — see the full Beta-methylphenethylamine (bmpea) list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking Beta-methylphenethylamine (bmpea) and Dextromethorphan, Pseudoephedrine, Triprolidine Together: Common Questions
Can you take Beta-methylphenethylamine (bmpea) with Dextromethorphan, Pseudoephedrine, Triprolidine?
Why are there 3 interactions listed for Beta-methylphenethylamine (bmpea) and Dextromethorphan, Pseudoephedrine, Triprolidine?
How serious is the Beta-methylphenethylamine (bmpea) and Dextromethorphan, Pseudoephedrine, Triprolidine interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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