Drug & supplement interaction

Calcium D-glucarate + Penicillamine

Penicillamine brand names: Cuprimine, Depen Titratable.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Calcium D-glucarate and Penicillamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, there is a timing consideration — Calcium D-glucarate can reduce how much Penicillamine you absorb if they are taken together, so they should be spaced apart, and the label for Penicillamine states a food rule worth keeping to.

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Interaction report

Calcium D-glucarate and Penicillamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Penicillamine and Calcium D-glucarate in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Calcium D-glucarate safety at a glance

Calcium D-glucarat... overall Use caution It appears generally well tolerated in small studies, but long-term safety in humans is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Penicillamine and Calcium D-glucarate? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Penicillamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Penicillamine is filed under 3 classifications — including nephrotoxic drugs, oral drugs. Calcium D-glucarate has documented interactions with 3 drug classes — the most serious being alcohol (ethanol) (moderate), glucuronidated drugs (moderate) and kanamycin (minor) — and none of Penicillamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Calcium D-glucarate Does Interact With Other Medications

Calcium D-glucarate has 125 moderate, 1 minor known drug interactions in our database — Penicillamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 125 Minor 1 No known interaction 2,704 (incl. Penicillamine)
Taking anything else?

Check Another of Your Medications Against Calcium D-glucarate

Covers the 2,830 medications we’ve checked against Calcium D-glucarate. Pick one to open its full report.

What to actually watch for

What Penicillamine’s Own FDA Label Lists

This is not an interaction — none of it involves Calcium D-glucarate. These are the most notable effects listed in the ADVERSE REACTIONS section of Penicillamine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Muscle weakness Worth acting on
  • Bleeding in the gut Worth acting on
  • Low blood sugar Worth acting on
  • Blood clots Worth acting on
  • Pancreatitis Worth acting on
  • Wheezing Worth acting on
  • A severe skin reaction Worth acting on
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on

Showing the 10 most notable of 26 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Penicillamine. Read the label on DailyMed › Where a percentage is shown, it is the share of 917 voluntary FDA FAERS reports for Penicillamine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Calcium D-glucarate’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Calcium D-glucarate side to compare — that is a limit of the record, not a statement that Calcium D-glucarate has no side effects.

Timing matters

No Interaction — But Take Calcium D-glucarate and Penicillamine a Few Hours Apart

Penicillamine is a chelating agent, and it is absorbed best on its own. Calcium D-glucarate can bind to it in the stomach so that less of the medicine reaches your bloodstream. That is not an interaction in the usual sense — nothing harmful happens when they meet — but taken at the same time, your dose can effectively become a smaller one.

The fix is simple: separate the two by about 4 hours. Take Penicillamine first, on its own, and keep Calcium D-glucarate for later in the day.

Where this comes from: this is HelloPharmacist editorial guidance, not a licensed interaction record — it applies established absorption pharmacology to chelating agents, whose FDA labels state a separation requirement of their own. The Penicillamine label is summarised on our Penicillamine drug page, and the full label is on DailyMed. Reviewed by the HelloPharmacist pharmacy team. If you already take them together, do not change your medicine on your own; ask your pharmacist how to space them.

How to take them

Some Penicillamine Products Have a Food Rule — Calcium D-glucarate Should Not Break It

At least one FDA label for a product containing Penicillamine says to take it on an empty stomach. Most supplements — Calcium D-glucarate included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Penicillamine on its own and move Calcium D-glucarate to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Penicillamine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION In all patients receiving penicillamine, it is important that CUPRIMINE be given on an empty stomach, at least one hour before meals or two hours after meals, and at least one hour apart from any other drug, food, or milk.

From the Dosage and Administration section of the FDA label we read for Penicillamine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Penicillamine

This page covers Calcium D-glucarate only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Penicillamine page lists 26 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), Aristolochia (moderate) and Coffee Charcoal (moderate).

By severity: 3 major · 13 moderate · 10 minor.

From our pharmacist’s overview on the Penicillamine page

“People take penicillamine (Cuprimine, Depen) for demanding conditions, Wilson's disease, rheumatoid arthritis, cystinuria, and its 26 supplement interactions are not a list to skim, three of them rated major. Seventeen ingredients can keep an oral dose from being fully absorbed, activated charcoal chief among them, and six more can str…”

Reviewed by 2 · Jul 18, 2026

Open the Penicillamine interaction page

One more smart check

Taking Calcium D-glucarate as Part of a Dietary Supplement Product? Check It for Interactions

We hold 369 real supplement products containing Calcium D-glucarate, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Calcium D-glucarate. Even though Calcium D-glucarate itself has no known interaction with Penicillamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Calcium D-glucarate and Penicillamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Calcium D-glucarate
Top half

#428 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Penicillamine
Steady interest

#2,653 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Calcium D-glucarate reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Calcium D-glucarate and Penicillamine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Calcium D-glucarate

What is Calcium D-glucarate?

Calcium D-glucarate
  • Detoxification support
  • Hormone balance
  • Estrogen metabolism
  • Liver support
  • General wellness

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the body clear excess hormones. Human evidence for these benefits is very limited, and most research comes from laboratory or animal studies. Talk to your pharmacist or doctor before using it, especially if you have a hormone-related condition.

Not applicable (a calcium salt of D-glucaric acid) · Tablets, capsules

An interaction check asks whether these two react with each other — it does not ask whether Calcium D-glucarate is a good idea for someone in your situation. Here is what our Calcium D-glucarate record says about it on its own.

Calcium D-glucarate: dosing

There is no official or standardized dose for calcium D-glucarate, and the best dose for any health goal has not been established in humans. Amounts used in supplements vary widely from product to product.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Calcium D-glucarate monograph — the full record covers uses, side effects and every documented interaction.

Read the full Calcium D-glucarate monograph & all interactions
Medication

About Penicillamine

What Is Penicillamine Used For?

Brand names: Cuprimine, Depen Titratable

Penicillamine is used for three distinct conditions. It treats Wilson's disease — a rare genetic disorder in which the body accumulates dangerous levels of copper — by binding to the excess copper and helping the body remove it. It also treats cystinuria, a condition where the amino acid cystine builds up and forms painful kidney stones, by converting cystine into a more soluble form that the body can excrete more easily.

For patients with severe, active rheumatoid arthritis who have not responded adequately to conventional therapies, penicillamine (available as Aagylur, Cuprimine, Depen, and other products) may be used to help suppress disease activity and reduce joint pain, tenderness, and swelling.

See full Penicillamine drug information
Keep checking

Other Drugs & Calcium D-glucarate

Browse every other medication we’ve checked against Calcium D-glucarate — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
125Moderate
1Minor
2,703No known interaction
125 Moderate 1 Minor 2,703 No interaction
Moderate

125 interactions

Showing 60 of 125 moderate interactions — see all 125 on the Calcium D-glucarate page.

Minor

1 interaction

No interaction 2,703 drugs checked — show the list

We also checked Calcium D-glucarate against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,703 medications checked with no known interaction — see the full Calcium D-glucarate list.

See the full Calcium D-glucarate interactions page
See every supplement checked against Penicillamine, ranked by severity
Evidence & sources

Calcium D-glucarate References

The 5 references that drive our Calcium D-glucarate monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. Biochem Med Metab Bio 1990;43:83-92.
  2. Furuno K, Matsubara S, Ando K, Suzuki S. Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 1976;29:950-3. PubMed
  3. Mezey E. Increased urinary excretion of D-glucarate acid in alcoholism. Res Commun Chem Pathol Pharmacol 1976;15:735-42.
  4. Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
  5. Anon. Calcium-D-Glucarate. Altern Med Review 2002;7(4):336-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Calcium D-glucarate and Penicillamine Together: Common Questions

Is it safe to take Calcium D-glucarate with Penicillamine?
We do not list a known interaction between Calcium D-glucarate and Penicillamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Calcium D-glucarate and Penicillamine at the same time of day?
At least one FDA label for a product containing Penicillamine says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Penicillamine on its own and move Calcium D-glucarate to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How far apart should I space Calcium D-glucarate and Penicillamine?
Calcium D-glucarate can bind Penicillamine in the gut and reduce how much of it you absorb, so they should not be swallowed together. The separation this page recommends is in the timing section above. Spacing them is about absorption — it is not a warning that they react with each other.
How was the Calcium D-glucarate and Penicillamine combination checked?
Interactions in our licensed database are recorded against drug classes. Penicillamine is filed under 3 classifications, and Calcium D-glucarate has documented interactions with 3 drug classes — none of Penicillamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Calcium D-glucarate interact with any other medications?
Yes. Calcium D-glucarate has 126 documented drug interactions in our database — Penicillamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Penicillamine interact with any supplements?
Yes. Penicillamine has documented interactions with 26 supplements in our database — Calcium D-glucarate is not one of them. The Penicillamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Calcium D-glucarate monograph Uses, safety profile, and every drug interaction in one place Penicillamine drug information The full plain-English guide to this medication Penicillamine supplement interactions Every supplement checked against Penicillamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Penicillamine and Calcium D-glucarate?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.