Drug & supplement interaction

Cubebs + Ramucirumab

Ramucirumab brand name: Cyramza.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cubebs and Ramucirumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Cubebs and Ramucirumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ramucirumab and Cubebs in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cubebs safety at a glance

Cubebs overall Use caution Likely fine in small culinary amounts, but safety of medicinal doses and the essential oil is not well studied.
Pregnancy Avoid Not enough safety information, so it is best avoided in medicinal amounts during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ramucirumab and Cubebs? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Cubebs Does Interact With Other Medications

Cubebs has 643 moderate, 22 minor known drug interactions in our database — Ramucirumab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 643 Minor 22 No known interaction 2,165 (incl. Ramucirumab)
Taking anything else?

Check Another of Your Medications Against Cubebs

Covers the 2,830 medications we’ve checked against Cubebs. Pick one to open its full report.

What to actually watch for

What Ramucirumab’s Own FDA Label Lists

This is not an interaction — none of it involves Cubebs. These are the most notable effects listed in the ADVERSE REACTIONS section of Ramucirumab’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A bowel blockage Worth acting on
  • Low sodium Worth acting on
  • A low white blood cell count Worth acting on mentioned in 8.5% of FDA reports for Ramucirumab
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on
  • Raised blood pressure Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on

Showing the 10 most notable of 19 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ramucirumab. Read the label on DailyMed › Where a percentage is shown, it is the share of 6,109 voluntary FDA FAERS reports for Ramucirumab that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Cubebs’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Cubebs side to compare — that is a limit of the record, not a statement that Cubebs has no side effects.

One more smart check

Taking Cubebs as Part of a Dietary Supplement Product? Check It for Interactions

We hold 19 real supplement products containing Cubebs, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cubebs. Even though Cubebs itself has no known interaction with Ramucirumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cubebs and Ramucirumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cubebs
Top half

#472 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ramucirumab
Steady interest

#2,583 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cubebs reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cubebs and Ramucirumab records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cubebs

What is Cubebs?

Cubebs
  • Coughs and bronchitis
  • Indigestion and gas
  • Urinary tract complaints
  • Sore throat
  • Culinary spice

Cubebs are spicy, peppery berries from a vine in the pepper family that have long been used in traditional medicine for coughs, digestion, and urinary problems. Modern human studies are very limited, so its benefits are not well proven. Use it cautiously as a food spice, and talk to your pharmacist or doctor before using concentrated extracts or oils.

Piper cubeba · Piperaceae · Dried unripe berries (fruit) and essential oil · Dried berries, powder, essential oil, tinctures, lozenges

An interaction check asks whether these two react with each other — it does not ask whether Cubebs is a good idea for someone in your situation. Here is what our Cubebs record says about it on its own.

Cubebs: dosing

There is no well-established, standardized medicinal dose for cubebs. Traditional uses varied widely, and modern research has not defined a safe and effective amount.If you choose to use a cubeb product, follow the directions on the label and do not exceed the recommended amount. Essential oil should never be swallowed undiluted.

From our Cubebs monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cubebs monograph & all interactions
Medication

About Ramucirumab Injection

What Is Ramucirumab Injection Used For?

Brand name: Cyramza

Cyramza (ramucirumab) injection is used to treat several types of advanced or metastatic cancer in adults. It is used for advanced or metastatic gastric (stomach) cancer or gastro-esophageal junction cancer that has progressed after prior chemotherapy — either alone or combined with paclitaxel. It is also used for metastatic non-small cell lung cancer, either with erlotinib as a first-line treatment for tumors with certain EGFR mutations, or with docetaxel after platinum-based chemotherapy has stopped working.

Additionally, Cyramza is used with FOLFIRI chemotherapy for metastatic colorectal cancer that has progressed after certain prior treatments, and as a single agent for hepatocellular carcinoma (a type of liver cancer) in patients who have elevated alpha-fetoprotein levels and have already received sorafenib.

Most-Reported Side Effects for Ramucirumab

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Malignant neoplasm progression 810 reports
Interstitial lung disease 299 reports
Neutropenia 263 reports
Febrile neutropenia 262 reports
Decreased appetite 231 reports
See full Ramucirumab Injection drug information
Keep checking

Other Drugs & Cubebs

Browse every other medication we’ve checked against Cubebs — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
643Moderate
22Minor
2,164No known interaction
643 Moderate 22 Minor 2,164 No interaction
Moderate

643 interactions

Showing 60 of 643 moderate interactions — see all 643 on the Cubebs page.

Minor

22 interactions

No interaction 2,164 drugs checked — show the list

We also checked Cubebs against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,164 medications checked with no known interaction — see the full Cubebs list.

See the full Cubebs interactions page
See every supplement checked against Ramucirumab, ranked by severity
Evidence & sources

Cubebs References

The 2 references that drive our Cubebs monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Usia T, Watabe T, Kadota S, Tezuka Y. Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod 2005;68(1):64-8.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cubebs and Ramucirumab Together: Common Questions

Is it safe to take Cubebs with Ramucirumab?
We do not list a known interaction between Cubebs and Ramucirumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Cubebs interact with any other medications?
Yes. Cubebs has 665 documented drug interactions in our database — Ramucirumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cubebs monograph Uses, safety profile, and every drug interaction in one place Ramucirumab Injection drug information The full plain-English guide to this medication Ramucirumab supplement interactions Every supplement checked against Ramucirumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ramucirumab and Cubebs?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.