Drug & supplement interaction

Elderberry + Sutimlimab-jome

Sutimlimab-jome brand name: Enjaymo.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Elderberry has a moderate interaction with Sutimlimab-jome. Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Elderberry and Sutimlimab-jome

Here is the interaction we found between these two, with the evidence behind it.

Moderate

IMMUNOSUPPRESSANTS

Why this applies to Sutimlimab-jome

Sutimlimab-jome falls under IMMUNOSUPPRESSANTS — the group Elderberry interacts with.

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the idea behind this pairing. Sutimlimab (Enjaymo) is an infused antibody that quiets one specific part of your immune system, the classical complement pathway, to keep red blood cells from being destroyed in cold agglutinin disease. Elderberry, on the other hand, may nudge parts of the immune system in the opposite direction by boosting signals like interleukins and TNF. So in theory, elderberry could push back against what the medicine is trying to calm down.

I want to be straight with you though: this concern is mostly theoretical and comes from lab work, not from real patients taking these two together. Whether occasional elderberry would actually reduce your treatment's benefit isn't proven. Since this drug treats a serious blood condition, it's worth a quick chat with your hematologist or pharmacist before adding elderberry, rather than guessing on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Elderberry Also Interacts With Other Medications

Elderberry has 120 moderate known drug interactions in our database — the Sutimlimab-jome one above is one of them. If you take anything else, check it against the full list below.

Moderate 120 No known interaction 2,710 (incl. Sutimlimab-jome)
Taking anything else?

Check Another of Your Medications Against Elderberry

Covers the 2,830 medications we’ve checked against Elderberry. Pick one to open its full report.

From our Q&A

Questions About Elderberry or Sutimlimab-jome

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Elderberry or Sutimlimab-jome, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sutimlimab-jome

This page covers Elderberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sutimlimab-jome page lists 53 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate), Andrographis (moderate) and Ashwagandha (moderate).

By severity: 52 moderate · 1 minor.

Open the Sutimlimab-jome interaction page

One more smart check

Taking Elderberry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 226 real supplement products containing Elderberry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Elderberry. Your product may carry other ingredients that interact with Sutimlimab-jome too, on top of Elderberry — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Elderberry and Sutimlimab-jome Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Elderberry
Top 25%

#333 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sutimlimab-jome
Top half

#808 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Elderberry

What is Elderberry?

Elderberry
  • Colds
  • Flu (influenza)
  • Other respiratory infections
  • Immune support
  • Sinus and upper respiratory symptoms

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and not conclusive. Cooked berries and properly prepared products are generally well tolerated, but raw or unripe parts can cause nausea and should be avoided.

Read the full Elderberry monograph & all interactions
Medication

About Sutimlimab-jome Injection

What Is Sutimlimab-jome Injection Used For?

Brand name: Enjaymo

Enjaymo (sutimlimab-jome) injection is indicated for the treatment of hemolysis — the breakdown of red blood cells — in adults with cold agglutinin disease (CAD). CAD is a rare autoimmune condition in which the immune system mistakenly attacks and destroys red blood cells, especially in cold temperatures.

Enjaymo works to stop this destruction by targeting a key part of the immune system called the classical complement pathway. It is approved for adults only; safety and effectiveness in children have not been established.

See full Sutimlimab-jome Injection drug information
Keep checking

Other Drugs & Elderberry

Browse every other medication we’ve checked against Elderberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
120Moderate
0Minor
2,709No known interaction
120 Moderate 2,709 No interaction
Moderate

120 interactions

Showing 60 of 120 moderate interactions — see all 120 on the Elderberry page.

No interaction 2,709 drugs checked — show the list

We also checked Elderberry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,709 medications checked with no known interaction — see the full Elderberry list.

See the full Elderberry interactions page
See every supplement checked against Sutimlimab-jome, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Elderberry monograph › Uses, safety, and every drug interaction in one place Sutimlimab-jome supplement interactions › Every supplement checked against Sutimlimab-jome, ranked by severity Sutimlimab-jome Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Elderberry and Sutimlimab-jome Together: Common Questions

Can you take Elderberry with Sutimlimab-jome?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Elderberry and Sutimlimab-jome interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Sutimlimab-jome and Elderberry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.