Drug & supplement interaction

Equol + Levoleucovorin

Levoleucovorin brand name: Khapzory.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Equol and Levoleucovorin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Equol and Levoleucovorin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Levoleucovorin and Equol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Equol safety at a glance

Equol overall Use caution Generally well tolerated in studies, but long-term safety and effects on hormone-sensitive conditions are not well established.
Pregnancy Avoid Not enough safety data and possible hormone-like effects, so it is best avoided.
Breastfeeding Avoid There is no reliable safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Levoleucovorin and Equol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Equol Does Interact With Other Medications

Equol has 58 moderate, 75 minor known drug interactions in our database — Levoleucovorin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 58 Minor 75 No known interaction 2,697 (incl. Levoleucovorin)
Taking anything else?

Check Another of Your Medications Against Equol

Covers the 2,830 medications we’ve checked against Equol. Pick one to open its full report.

What to actually watch for

What Equol Itself Has Been Linked To

This is not an interaction — nothing below involves Levoleucovorin. It is the side-effect record for Equol on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Equol, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Low mood Worth acting on Additional detail

    “Orally, equol has been rarely reported to cause depression.”

    Equol · Natural Medicines adverse-effect record, reported in depression.

    1 source cited
    1. 19075. Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency. J Womens Health (Larchmt) 2012;21:674-82.
  • Bloating or gas Additional detail

    Recorded for Equol in the same Natural Medicines adverse-effect record shown under Low mood above.

  • Constipation Additional detail

    “Orally, equol has been reported to cause abdominal distention and constipation.”

    Equol · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 19075. Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency. J Womens Health (Larchmt) 2012;21:674-82.

Everything above comes from the Natural Medicines adverse-effect record for Equol — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Levoleucovorin’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Levoleucovorin column appears here.

How much people look this up

Where Equol and Levoleucovorin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Equol
Top half

#625 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Levoleucovorin
Steady interest

#2,678 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Equol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Equol and Levoleucovorin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Equol

What is Equol?

  • Menopause symptoms (hot flashes)
  • Bone health support
  • Skin aging
  • Prostate health
  • General hormone balance

Equol is a compound made in the gut when some people break down soy isoflavones, and it is also sold as a supplement. Early research links it to possible benefits for menopause symptoms and bone or skin health, but the evidence is still limited and far from proven. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Not a plant part; a metabolite produced by gut bacteria from soy isoflavones (daidzein) · Capsules, tablets, and as a component of fermented soy or red clover supplements

An interaction check asks whether these two react with each other — it does not ask whether Equol is a good idea for someone in your situation. Here is what our Equol record says about it on its own.

Equol: dosing

There is no official or standardized dose of equol. Amounts used in research have varied, and supplement products differ in how much they contain.The best approach is to follow the directions on the product label and not take more than recommended.

From our Equol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Equol monograph & all interactions
Medication

About Levoleucovorin Injection

What Is Levoleucovorin Injection Used For?

Brand name: Khapzory

Levoleucovorin injection (brands: Fusilev, Khapzory) is used intravenously in three main situations. First, it is given as a "rescue" treatment after high-dose methotrexate chemotherapy in osteosarcoma (bone cancer) — helping to limit the toxic effects methotrexate can have on healthy cells. Second, it is used when methotrexate is not clearing the body fast enough, or when there has been an accidental overdose of methotrexate or similar drugs called folic acid antagonists.

Third, levoleucovorin injection is used alongside the chemotherapy drug 5-fluorouracil (5-FU) for the palliative treatment of advanced metastatic colorectal cancer — meaning it helps make 5-FU work better, though the goal is disease control rather than cure. It is not approved for pernicious anemia or megaloblastic anemias related to vitamin B12 deficiency.

Most-Reported Side Effects for Levoleucovorin

From FAERS, the FDA’s public side-effect reporting system (3,706 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 288 reports
Neutropenia 251 reports
Diarrhea 246 reports
Decreased appetite 187 reports
Vomiting 171 reports
See full Levoleucovorin Injection drug information
Keep checking

Other Drugs & Equol

Browse every other medication we’ve checked against Equol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
58Moderate
75Minor
2,696No known interaction
58 Moderate 75 Minor 2,696 No interaction
Moderate

58 interactions

Minor

75 interactions

Showing 60 of 75 minor interactions — see all 75 on the Equol page.

No interaction 2,696 drugs checked — show the list

We also checked Equol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,696 medications checked with no known interaction — see the full Equol list.

See the full Equol interactions page
See every supplement checked against Levoleucovorin, ranked by severity
Evidence & sources

Equol References

The 7 references that drive our Equol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Aso T. Equol improves menopausal symptoms in Japanese women. J Nutr 2010;140:1386S-9S. PubMed
  2. Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency. J Womens Health (Larchmt) 2012;21:674-82.
  3. Oyama A, Ueno T, Uchiyama S, et al. The effects of natural S-equol supplementation on skin aging in postmenopausal women: a pilot randomized placebo-controlled trial. Menopause 2012;19:202-10. PubMed
  4. Gimenez I, Lou M, Vargas F, et al. Renal and vascular actions of equol in the rat. J Hypertens 1997;15:1303-8. PubMed
  5. Martin ME, Haouriqui M, Pelissero C, et al. Interactions between phytoestrogens and human sex steroid binding protein. Life Sci 1996;58:429-36. PubMed
  6. Martinez RM, Gimenez I, Lou JM, et al. Soy isoflavonoids exhibit in vitro biological activities of loop diuretics. Am J Clin Nutr 1998;68:1354S-57S. PubMed
  7. Alda JO, Mayoral JA, Lou M, et al. Purification and chemical characterization of a potent inhibitor of the Na-K-Cl cotransport system in rat urine. Biochem Biophys Res Commun 1996;221:279-85. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Equol and Levoleucovorin Together: Common Questions

Is it safe to take Equol with Levoleucovorin?
We do not list a known interaction between Equol and Levoleucovorin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Equol interact with any other medications?
Yes. Equol has 133 documented drug interactions in our database — Levoleucovorin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Equol monograph Uses, safety profile, and every drug interaction in one place Levoleucovorin Injection drug information The full plain-English guide to this medication Levoleucovorin supplement interactions Every supplement checked against Levoleucovorin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Levoleucovorin and Equol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.