Drug & supplement interaction

Flaxseed Oil + Atazanavir

Atazanavir brand name: Reyataz.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Flaxseed Oil and Atazanavir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Atazanavir states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Flaxseed Oil and Atazanavir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Atazanavir and Flaxseed Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Flaxseed Oil safety at a glance

Flaxseed Oil overall Use caution Generally well tolerated for most adults, but quality and dose vary by product.
Pregnancy Possibly Safe When used orally and appropriately for medicinal purposes, short-term. Although flaxseed oil has been used with apparent safety in clinical research in doses of... Read the full pregnancy detail
Breastfeeding Use caution Limited safety information during breastfeeding, so use only with medical advice.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Atazanavir and Flaxseed Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Atazanavir

Interactions in our licensed database are recorded against drug classes, not just single drug names. Atazanavir is filed under 7 classifications — including protease inhibitors (pis), cytochrome p450 2c9 (cyp2c9) inhibitors, cytochrome p450 1a2 (cyp1a2) inhibitors. Flaxseed Oil has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antihypertensive drugs (moderate) and ezetimibe (zetia) (moderate) — and none of Atazanavir’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Flaxseed Oil Does Interact With Other Medications

Flaxseed Oil has 293 moderate known drug interactions in our database — Atazanavir isn’t one of them. If you take anything else, check it against the full list below.

Moderate 293 No known interaction 2,537 (incl. Atazanavir)
Taking anything else?

Check Another of Your Medications Against Flaxseed Oil

Covers the 2,830 medications we’ve checked against Flaxseed Oil. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Flaxseed Oil and Atazanavir May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea Additional detail

    Flaxseed Oil

    “Orally, flaxseed oil may cause a change in bowel habits, dry mouth, and dyspepsia when taken at a dose of about 5 grams daily. However, these effects have been reported by only a small number of patients (approximately 3%). High doses of flaxseed oil (30 grams per day and higher) have been associated with loose stools and diarrhea.”

    Flaxseed Oil · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 16794. Harper CR, Edwards MC, Jacobson TA. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. J Nutr 2006;136:2844-8. PubMed
    2. 5898. Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
    3. 11025. Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev 2004;62:18-27. DOI

    Atazanavir

    Listed in the ADVERSE REACTIONS section of the FDA label for Atazanavir. Read the label on DailyMed ›

Reported for Flaxseed Oil but not commonly for Atazanavir: an allergic reaction, a severe allergic reaction, stomach upset and dry mouth.

Effects for Atazanavir come from the ADVERSE REACTIONS section of its FDA label; effects for Flaxseed Oil come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 14,470 voluntary FDA FAERS reports for Atazanavir that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Flaxseed Oil in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally and appropriately for medicinal purposes, short-term. Although flaxseed oil has been used with apparent safety in clinical research in doses of 1-2 grams daily for up to 6 weeks, some population research has found that consuming flaxseed oil during the second and third trimesters of pregnancy is associated with a four-fold increased risk of premature birth.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Atazanavir Products Have a Food Rule — Flaxseed Oil Should Not Break It

At least one FDA label for a product containing Atazanavir says to take it with food. If you take Flaxseed Oil on an empty stomach out of habit, keep them separate — and take Atazanavir with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Atazanavir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

b For adult patients who cannot swallow the capsules, REYATAZ oral powder is taken once daily with food at the same recommended adult dosage as the capsules along with ritonavir.

From the Dosage and Administration section of the FDA label we read for Atazanavir — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Atazanavir

This page covers Flaxseed Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atazanavir page lists 152 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 107 moderate · 42 minor.

From our pharmacist’s overview on the Atazanavir page

“Atazanavir (Reyataz) treats HIV, and keeping its blood level steady is what stands between viral control and drug resistance, so I read this list with genuine care. Of the 152 supplement and herbal ingredients on file, three carry a major rating: St.”

Reviewed by 2 · Jul 18, 2026

Open the Atazanavir interaction page

One more smart check

Taking Flaxseed Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,329 real supplement products containing Flaxseed Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Flaxseed Oil. Even though Flaxseed Oil itself has no known interaction with Atazanavir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Flaxseed Oil and Atazanavir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Flaxseed Oil
Top 25%

#188 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Atazanavir
Top half

#719 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Flaxseed Oil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Flaxseed Oil and Atazanavir records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Flaxseed Oil

What is Flaxseed Oil?

  • Source of omega-3 (ALA) fatty acids
  • Heart and cholesterol health
  • Dry skin and inflammation
  • Constipation
  • General wellness

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy fats, but evidence for most specific health claims is limited or mixed. It is generally well tolerated, but talk to your pharmacist or doctor before starting, especially if you are pregnant or have a bleeding risk.

Linum usitatissimum · Linaceae · Oil pressed from the seeds · Liquid oil, softgel capsules, salad oil

An interaction check asks whether these two react with each other — it does not ask whether Flaxseed Oil is a good idea for someone in your situation. Here is what our Flaxseed Oil record says about it on its own.

Flaxseed Oil: dosing

There is no official standardized dose of flaxseed oil for any health condition. Products vary widely in strength and in how much ALA they provide per serving.The safest approach is to follow the dose printed on the product label and not exceed it without medical advice. To keep the oil fresh, store it as directed (often refrigerated) and avoid using it for cooking at high heat.

From our Flaxseed Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Flaxseed Oil monograph & all interactions
Medication

About Atazanavir

What Is Atazanavir Used For?

Brand name: Reyataz

Atazanavir capsules are used together with other antiretroviral medicines to treat HIV-1 infection in adults and in children 6 years and older who weigh at least 15 kg (about 33 lbs).

Reyataz — available as capsules and as an oral powder — is also approved for HIV-1 treatment in adults and in children as young as 3 months who weigh at least 5 kg (about 11 lbs). Reyataz oral powder must always be taken with ritonavir and food, and is not for use in children weighing less than 5 kg.

Most-Reported Side Effects for Atazanavir

From FAERS, the FDA’s public side-effect reporting system (14,470 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Depression 1,318 reports
Foetal exposure during pregnancy 1,048 reports
Anxiety 878 reports
Emotional distress 660 reports
Anhedonia 601 reports
See full Atazanavir drug information
Keep checking

Other Drugs & Flaxseed Oil

Browse every other medication we’ve checked against Flaxseed Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
293Moderate
0Minor
2,536No known interaction
293 Moderate 2,536 No interaction
Moderate

293 interactions

Showing 60 of 293 moderate interactions — see all 293 on the Flaxseed Oil page.

No interaction 2,536 drugs checked — show the list

We also checked Flaxseed Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,536 medications checked with no known interaction — see the full Flaxseed Oil list.

See the full Flaxseed Oil interactions page
See every supplement checked against Atazanavir, ranked by severity
Evidence & sources

Flaxseed Oil References

The 21 references that drive our Flaxseed Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
  2. Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
  3. Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
  4. De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
  5. Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
  6. Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev 2004;62:18-27. DOI
  7. Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.. PubMed
  8. Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22.
  9. Paschos GK, Magkos F, Panagiotakos DB, et al. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 2007;61:1201-6. PubMed
  10. Harper CR, Edwards MC, Jacobson TA. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. J Nutr 2006;136:2844-8. PubMed
  11. University of Montreal. Pregnant Women Consuming Flaxseed Oil Have High Risk Of Premature Birth.ScienceDaily, October 29, 2008. Available at: www.sciencedaily.com/releases/2008/10/081027140817.htm (Accessed May 14, 2009).
  12. Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178.
  13. Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial. Clin Nutr. 2016 Jun;3 PubMed
  14. Taghizadeh M, Jamilian M, Mazloomi M, Sanami M, Asemi Z. A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids on vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. J
  15. Blackwood DP, LaVallee RK, Al Busaidi A, Jassal DS, Pierce GN. A randomized trial of the effects of ezetimibe on the absorption of omega-3 fatty acids in cardiac disease patients: a pilot study. Clin Nutr ESPEN. 2015 Oct;10(5):e155-e159. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Flaxseed Oil and Atazanavir Together: Common Questions

Is it safe to take Flaxseed Oil with Atazanavir?
We do not list a known interaction between Flaxseed Oil and Atazanavir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Flaxseed Oil and Atazanavir have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Flaxseed Oil and Atazanavir at the same time of day?
At least one FDA label for a product containing Atazanavir says to take it with food. If you take Flaxseed Oil on an empty stomach out of habit, keep them separate and take Atazanavir with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Atazanavir products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Flaxseed Oil and Atazanavir combination checked?
Interactions in our licensed database are recorded against drug classes. Atazanavir is filed under 7 classifications, and Flaxseed Oil has documented interactions with 3 drug classes — none of Atazanavir's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Flaxseed Oil interact with any other medications?
Yes. Flaxseed Oil has 293 documented drug interactions in our database — Atazanavir is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Atazanavir interact with any supplements?
Yes. Atazanavir has documented interactions with 152 supplements in our database — Flaxseed Oil is not one of them. The Atazanavir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Flaxseed Oil monograph Uses, safety profile, and every drug interaction in one place Atazanavir drug information The full plain-English guide to this medication Atazanavir supplement interactions Every supplement checked against Atazanavir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Atazanavir and Flaxseed Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.