Garden Cress + Treprostinil (Inh)
Treprostinil (Inh) brand name: Tyvaso.
Treprostinil (Inh) falls into 2 drug categories that Garden Cress can interact with; the most serious is rated moderate. Theoretically, taking garden cress with antihypertensive drugs might increase the risk of hypotension.
Read the full interaction reportGarden Cress and Treprostinil (Inh)
These two interact in 2 distinct ways. Each one is explained separately below.
Why Are There 2 Interactions?
Garden Cress interacts with whole categories of medication. Treprostinil (Inh) falls into 2 of those categories, so it can interact with Garden Cress in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ANTIHYPERTENSIVE DRUGS
1 of 2Why this applies to Treprostinil (Inh)
Treprostinil (Inh) falls under ANTIHYPERTENSIVE DRUGS — the group Garden Cress interacts with.
Garden cress has shown hypotensive effects in animal research and increases levels and effects of the antihypertensive medications amlodipine and losartan. This has not been shown in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the short version on pairing garden cress with inhaled treprostinil (Tyvaso). Treprostinil is a vasodilator, meaning it widens blood vessels to lower the pressure in your lungs. Garden cress, at least in animal studies, seems to nudge blood pressure downward too. So the theory is that stacking them could lower your blood pressure a bit more than expected, leaving you feeling lightheaded, dizzy, flushed, or faint, especially when you stand up quickly.
The important caveat: this concern comes from lab and animal work, not human studies, and it was seen with other blood pressure pills, not treprostinil specifically. Food amounts of cress are unlikely to matter. Concentrated seed supplements are the bigger question mark. Before adding them, please check with your pharmacist or doctor.
- Maghrani, M, Zeggwagh, NA, Michel, JB, and Eddouks, M. Antihypertensive effect of <it>Lepidium sativum</it> L. in spontaneously hypertensive rats. Journal of Ethnopharmacology (Ireland) 2005;100:193-197.
- Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol 2021;59(1):1088-1097. PubMed
- Alam MA, Bin Jardan YA, Raish M, Al-Mohizea AM, Ahad A, Al-Jenoobi FI. Herb-drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa. Xenobiotica 2022;52(2):177
- Ahad A, Raish M, Abdelrahman IA, et al. Changes in pharmacokinetics and pharmacodynamics of losartan in experimental diseased rats treated with Curcuma longa and Lepidium sativum. Pharmaceuticals (Basel) 2022;16(1):33. PubMed
ANTICOAGULANT/ANTIPLATELET DRUGS
2 of 2Treprostinil (Inh) also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.
Animal research suggests that garden cress seed extract can increase bleeding time when used in combination with the antiplatelet agent clopidogrel. This has not been shown in humans and it is unclear if garden cress seed itself has anticoagulant or antiplatelet effects.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to keep in mind with inhaled treprostinil (Tyvaso): besides relaxing the blood vessels in your lungs, it also makes your platelets a little less sticky, so it has a mild blood-thinning side to it. Garden cress seed might add to that effect. The concern is a slightly higher chance of bleeding or bruising, things like nosebleeds, bleeding gums, or bruises that show up more easily than usual.
I want to be honest about how weak this evidence is. It comes only from animal studies (with a different drug), and it hasn't been shown in people. Everyday culinary amounts of garden cress are very unlikely to matter. If you're thinking about concentrated seed supplements, run it by your pharmacist or doctor first.
- Alkharfy K, Jan B, Alotaibi K, et al. Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model. Curr Drug Metab 2021;22(12):969-977. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Garden Cress Also Interacts With Other Medications
Garden Cress has 397 moderate known drug interactions in our database — the Treprostinil (Inh) one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Garden Cress
We haven’t checked that one against Garden Cress yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Garden Cress. Pick one to open its full report.
See Every Supplement That Interacts With Treprostinil (Inh)
This page covers Garden Cress only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Treprostinil (Inh) page lists 275 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: American Hellebore (major), American Mistletoe (major), Danshen (major), Piracetam (major) and Tyramine (major).
By severity: 5 major · 251 moderate · 19 minor.
From our pharmacist’s overview on the Treprostinil (Inh) page
“Inhaled treprostinil (Tyvaso) relaxes blood vessels in the lungs to treat pulmonary hypertension, and it also blunts platelet clotting, which is why this list of 275 ingredients warrants real vigilance rather than a shrug. Two themes cover almost everything.”
Reviewed by 2 · Jul 18, 2026
Taking Garden Cress as Part of a Dietary Supplement Product? Check It for Interactions
We hold 16 real supplement products containing Garden Cress, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Garden Cress. Your product may carry other ingredients that interact with Treprostinil (Inh) too, on top of Garden Cress — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Garden Cress and Treprostinil (Inh) Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#912 of 1,452 supplements looked up here in the last 7 days
#1,069 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Garden Cress
What is Garden Cress?
- Digestive support
- Bone health
- Iron and vitamin source
- Cough and respiratory comfort
- Boosting breast milk (traditional)
- Constipation relief
Garden cress is a nutritious leafy herb and seed used widely in cooking and traditional medicine, providing vitamins, minerals, and fiber. While it has a long history of use for digestion, bone health, and lactation, strong human research supporting most medicinal claims is limited. It is generally safe as a food, but concentrated seed supplements should be used cautiously and avoided in pregnancy.
About Treprostinil Oral Inhalation
What Is Treprostinil Oral Inhalation Used For?
Brand name: Tyvaso
Treprostinil oral inhalation is used to treat two serious lung conditions that raise pressure in the blood vessels of the lungs. It helps improve how much physical activity you can do.
Tyvaso inhalation solution and Tyvaso DPI are both indicated to treat pulmonary arterial hypertension (PAH; WHO Group 1) and pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3). Clinical studies establishing effectiveness in PAH primarily included patients with moderate symptoms (NYHA Class III) whose PAH was idiopathic, heritable, or related to connective tissue disease. Studies in PH-ILD primarily included patients with idiopathic interstitial pneumonia, combined pulmonary fibrosis and emphysema, or connective tissue disease-related lung disease.
Other Drugs & Garden Cress
Browse every other medication we’ve checked against Garden Cress — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
397 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Insulin (rdna) ›
- Naproxen ›
- Minocycline ›
- Propranolol ›
- Hydrochlorothiazide ›
- Verapamil ›
- Glyburide ›
- Insulin (pork) ›
- Phenytoin ›
- Carbamazepine ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Hydralazine ›
- Insulin (human) ›
- Ketoprofen ›
- Trichlormethiazide ›
- Acarbose ›
- Bendroflumethiazide ›
- Bivalirudin ›
- Insulin Glargine ›
- Lisinopril ›
- Metolazone ›
- Minoxidil ›
- Nicardipine ›
- Prazosin ›
- Semaglutide ›
- Spironolactone ›
- Timolol ›
- Warfarin Sodium ›
- Acebutolol ›
- Acetazolamide ›
- Ambrisentan ›
- Amiloride ›
- Atenolol ›
- Betaxolol ›
- Bromfenac Sodium ›
- Candesartan Cilexetil ›
- Captopril ›
- Carteolol ›
- Carvedilol ›
- Chlorpropamide ›
- Chlorthalidone ›
- Cyclothiazide ›
- Dabigatran ›
- Diclofenac Epolamine ›
- Enalapril Maleate ›
- Exenatide ›
- Felodipine ›
- Glipizide ›
- Glucagon ›
- Guanethidine Monosulfate ›
- Iloprost ›
- Indapamide ›
- Insulin Lispro ›
Showing 60 of 397 moderate interactions — see all 397 on the Garden Cress page.
No interaction 2,432 drugs checked — show the list
We also checked Garden Cress against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Sertraline ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Atorvastatin ›
- Isotretinoin ›
- Methamphetamine ›
- Docusate ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Prednisone ›
- Tadalafil ›
- Amitriptyline ›
- Levothyroxine, Liothyronine ›
- Lisdexamfetamine ›
- Amphetamine ›
- Methotrexate ›
- Amoxicillin ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Doxycycline ›
- Pregabalin ›
- Bendamustine ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Acyclovir ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
- Ciprofloxacin ›
- Acetaminophen, Codeine ›
- Amoxicillin, Clavulanate Potassium ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine ›
- Acetaminophen, Butalbital, Caffeine ›
- Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide ›
- Acetaminophen, Caffeine, Codeine ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine ›
- Acetaminophen, Oxycodone ›
- Diazepam ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine ›
- Acetaminophen, Brompheniramine, Phenylpropanolamine ›
- Dapsone ›
- Acetaminophen, Chlorpheniramine, Phenylpropanolamine ›
- Ezetimibe ›
- Cephalexin ›
- Acetaminophen, Dichloralphenazone, Isometheptene ›
Showing the 60 most looked-up of 2,432 medications checked with no known interaction — see the full Garden Cress list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Treprostinil (Inh) Is Linked to Lower Levels of One Nutrient
Natural Medicines records Treprostinil (Inh) as a medicine that can lower these. This is not an interaction with Garden Cress — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Treprostinil (Inh) nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Garden Cress and Treprostinil (Inh) Together: Common Questions
Can you take Garden Cress with Treprostinil (Inh)?
Why are there 2 interactions listed for Garden Cress and Treprostinil (Inh)?
How serious is the Garden Cress and Treprostinil (Inh) interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.