Drug & supplement interaction

Glyconutrients + Alogliptin, Metformin

Alogliptin, Metformin brand name: Kazano.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Glyconutrients and Alogliptin, Metformin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Alogliptin, Metformin states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Glyconutrients and Alogliptin, Metformin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Alogliptin, Metformin and Glyconutrients in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Glyconutrients safety at a glance

Glyconutrients overall Use caution Generally low-risk for healthy adults, but benefits are unproven and product quality varies.
Pregnancy Avoid Safety has not been studied, so it is best to avoid during pregnancy.
Breastfeeding Avoid Not enough safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Alogliptin, Metformin and Glyconutrients? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Alogliptin, Metformin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Alogliptin, Metformin is filed under 4 classifications — including organic cation transporter 2 (oct2) substrates, antidiabetes drugs, oral drugs. Glyconutrients has documented interactions with 1 drug class — the most serious being immunosuppressants (moderate) — and none of Alogliptin, Metformin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Glyconutrients Does Interact With Other Medications

Glyconutrients has 121 moderate known drug interactions in our database — Alogliptin, Metformin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 121 No known interaction 2,709 (incl. Alogliptin, Metformin)
Taking anything else?

Check Another of Your Medications Against Glyconutrients

Covers the 2,830 medications we’ve checked against Glyconutrients. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Glyconutrients and Alogliptin, Metformin May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Bloating or gas Additional detail

    Glyconutrients

    “Orally, glyconutrients appear to be well tolerated. Side effects reported in clinical research have included gastrointestinal symptoms such as flatulence”

    Glyconutrients · Natural Medicines adverse-effect record, reported in flatulence.

    1 source cited
    1. 26790. Best T, Kemps E, Bryan J. Perceived changes in well-being following polysaccharide intake in middle-aged adults. Applied Res Qual Life 2012;7(2):183-192. DOI

    “Orally, side effects of glyconutrients reported in clinical research have included gastrointestinal symptoms such as flatulence.”

    Glyconutrients · Natural Medicines adverse-effect record, reported in flatulence.

    1 source cited
    1. 26790. Best T, Kemps E, Bryan J. Perceived changes in well-being following polysaccharide intake in middle-aged adults. Applied Res Qual Life 2012;7(2):183-192. DOI

    Alogliptin, Metformin

    Listed in the ADVERSE REACTIONS section of the FDA label for Alogliptin, Metformin. Read the label on DailyMed ›

Effects for Alogliptin, Metformin come from the ADVERSE REACTIONS section of its FDA label; effects for Glyconutrients come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Alogliptin, Metformin Products Have a Food Rule — Glyconutrients Should Not Break It

At least one FDA label for a product containing Alogliptin, Metformin says to take it with food. If you take Glyconutrients on an empty stomach out of habit, keep them separate — and take Alogliptin, Metformin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Alogliptin, Metformin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 ) Given orally twice daily with food.

From the Dosage and Administration section of the FDA label we read for Alogliptin, Metformin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Alogliptin, Metformin

This page covers Glyconutrients only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alogliptin, Metformin page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 217 moderate · 38 minor.

From our pharmacist’s overview on the Alogliptin, Metformin page

“Kazano combines alogliptin and metformin to lower blood sugar, and nearly everything on this list pushes on that same lever, so I treat these pairings with real caution. Most entries are herbs and supplements that lower glucose on their own, and stacked on the drug they raise the risk of hypoglycemia, a sugar drop steep enough to cause…”

Reviewed by 2 · Jul 18, 2026

Open the Alogliptin, Metformin interaction page

How much people look this up

Where Glyconutrients and Alogliptin, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Glyconutrients
Top half

#710 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Alogliptin, Metformin
Top half

#1,046 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Glyconutrients reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Glyconutrients and Alogliptin, Metformin records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Glyconutrients

What is Glyconutrients?

  • General immune support
  • Overall wellness and energy
  • Cognitive or memory support
  • Inflammation
  • Digestive health

Glyconutrients are supplements containing certain sugar molecules (monosaccharides) that marketers claim are essential for cell communication and health. The science behind most health claims is weak and largely promotional, and your body already makes these sugars from a normal diet. They are generally low-risk, but talk to your pharmacist or doctor before using them, and don't rely on them to treat any disease.

Not a single plant; refined sugars (monosaccharides) from sources like aloe vera, gums, larch, mushrooms, and seaweeds · Capsules, powders, chewable tablets, drink mixes

An interaction check asks whether these two react with each other — it does not ask whether Glyconutrients is a good idea for someone in your situation. Here is what our Glyconutrients record says about it on its own.

Glyconutrients: dosing

There is no official or standardized dose for glyconutrients. Products differ widely in their ingredients and strength, so a single recommended amount does not exist.If you choose to try one, follow the directions on the product label and do not take more than suggested. Choose products from reputable brands that use third-party testing when possible.

From our Glyconutrients monograph — the full record covers uses, side effects and every documented interaction.

Read the full Glyconutrients monograph & all interactions
Keep checking

Other Drugs & Glyconutrients

Browse every other medication we’ve checked against Glyconutrients — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
0Minor
2,708No known interaction
121 Moderate 2,708 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Glyconutrients page.

No interaction 2,708 drugs checked — show the list

We also checked Glyconutrients against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Glyconutrients list.

See the full Glyconutrients interactions page
See every supplement checked against Alogliptin, Metformin, ranked by severity
Evidence & sources

Glyconutrients References

The 9 references that drive our Glyconutrients monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Best T, Kemps E, Bryan J. Saccharide effects on cognition and well-being in middle-aged adults: a randomized controlled trial. Dev Neuropsychol 2010;35(1):66-80. PubMed
  2. Dykman KD, Dykman RA. Effect of nutritional supplements on attentional-deficit hyperactivity disorder. Integr Physiol Behav Sci 1998;33(1):49-60. PubMed
  3. Dykman K, Ford CR, Gardiner T. The effect of glyconutritional supplementation on toddlers with failure to thrive. Glycoscience Nutr 2000;1(36):1-7.
  4. Best T, Kemps E, Bryan J. Perceived changes in well-being following polysaccharide intake in middle-aged adults. Applied Res Qual Life 2012;7(2):183-192. DOI
  5. Lefkowitz DL, Stuart R, Gnade BT, Roberts E, Lefkowitz SS. Effects of a glyconutrient on macrophage functions. Int J Immunopharmacol 2000;22(4):299-308. PubMed
  6. See DM, Cimoch P, Chou S, Chang J, Tilles J. The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with chronic fatigue syndrome. Integr Physiol Behav Sci 1998;33(3):280-287. PubMed
  7. Best T, Bryan J, Burns N. An investigation of the effects of saccharides on the memory performance of middle-aged adults. J Nutr Health Aging 2008;12(9):657-662. PubMed
  8. Stancil AN, Hicks LH. Glyconutrients and perception, cognition, and memory. Percept Mot Skills 2009;108(1):259-270. PubMed
  9. Haji, Faraji M. and Haji, Tarkhani A. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. J.Ethnopharmacol. 1999;65(3):231-236. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Glyconutrients and Alogliptin, Metformin Together: Common Questions

Is it safe to take Glyconutrients with Alogliptin, Metformin?
We do not list a known interaction between Glyconutrients and Alogliptin, Metformin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Glyconutrients and Alogliptin, Metformin have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Glyconutrients and Alogliptin, Metformin at the same time of day?
At least one FDA label for a product containing Alogliptin, Metformin says to take it with food. If you take Glyconutrients on an empty stomach out of habit, keep them separate and take Alogliptin, Metformin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Alogliptin, Metformin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Glyconutrients and Alogliptin, Metformin combination checked?
Interactions in our licensed database are recorded against drug classes. Alogliptin, Metformin is filed under 4 classifications, and Glyconutrients has documented interactions with 1 drug class — none of Alogliptin, Metformin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Glyconutrients interact with any other medications?
Yes. Glyconutrients has 121 documented drug interactions in our database — Alogliptin, Metformin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Alogliptin, Metformin interact with any supplements?
Yes. Alogliptin, Metformin has documented interactions with 257 supplements in our database — Glyconutrients is not one of them. The Alogliptin, Metformin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Glyconutrients monograph Uses, safety profile, and every drug interaction in one place Alogliptin, Metformin supplement interactions Every supplement checked against Alogliptin, Metformin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.