Lion's Mane Mushroom - Sinemet (Carbidopa, Levodopa) Interaction
Herbal: Lion's Mane Mushroom
Also Known As: Bearded Tooth, Crinière de Lion, Hedgehog Fungus, Hydne Hérisson, Lion's Mane, Monkey Head, Monkey's Head, Pom Pom, Pompom, Satyr's Beard, Tree Hedgehog, Yamabushitake
Drug: Carbidopa, Levodopa
Brand names:
Sinemet CR, Sinemet, Rytary, Dhivy
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 08, 2025
Interaction Details
There were no interactions found between Carbidopa, Levodopa and Lion's Mane Mushroom. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Lion's Mane Mushroom Overview
Lion's mane mushroom (Hericium erinaceus) is a type of edible mushroom that grows on the dead trunks of several species of hardwood tree and is native to North America, Europe, and Asia. It is named for its long, shaggy spines that resemble the mane of a lion.
Lion's mane mushroom has been used as a dietary supplement for a number of purported health benefits. It is rich in antioxidants and may have anti-inflammatory properties, which may help to reduce the risk of chronic diseases such as heart disease. It is also believed to have neuroprotective effects and may help to improve cognitive function and memory, which is why it is often marketed as a 'nootropic'. In addition, lion's mane mushroom may have immune-boosting properties and may help to reduce the severity of colds and other infections.
Carbidopa, Levodopa Overview
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The combination of levodopa and carbidopa is used to treat the symptoms of Parkinson's disease and Parkinson's-like symptoms that may develop after encephalitis (swelling of the brain) or injury to the nervous system caused by carbon monoxide poisoning or manganese poisoning. Parkinson's symptoms, including tremors (shaking), stiffness, and slowness of movement, are caused by a lack of dopamine, a natural substance usually found in the brain. Levodopa is in a class of medications called central nervous system agents. It works by being converted to dopamine in the brain. Carbidopa is in a class of medications called decarboxylase inhibitors. It works by preventing levodopa from being broken down before it reaches the brain. This allows for a lower dose of levodopa, which causes less nausea and vomiting.
Lion's Mane Mushroom - More Interactions
Lion's Mane Mushroom interacts with 315 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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