Drug & supplement interaction

Lion's Mane Mushroom + Imiquimod

Imiquimod brand names: Aldara, Zyclara, Vyloma.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Lion's Mane Mushroom and Imiquimod in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Lion's Mane Mushroom and Imiquimod

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Imiquimod and Lion's Mane Mushroom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lion's Mane Mushroom safety at a glance

Lion's Mane Mushro... overall Use caution Generally well tolerated as a food, but supplement safety has not been well studied long-term.
Pregnancy Avoid Not enough safety data, so it is best to avoid during pregnancy.
Breastfeeding Avoid Not enough safety data, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Imiquimod and Lion's Mane Mushroom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Imiquimod

Interactions in our licensed database are recorded against drug classes, not just single drug names. Imiquimod is filed under a single classification — topical drugs. Lion's Mane Mushroom has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and immunosuppressants (moderate) — and none of Imiquimod’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Lion's Mane Mushroom Does Interact With Other Medications

Lion's Mane Mushroom has 327 moderate known drug interactions in our database — Imiquimod isn’t one of them. If you take anything else, check it against the full list below.

Moderate 327 No known interaction 2,503 (incl. Imiquimod)
Taking anything else?

Check Another of Your Medications Against Lion's Mane Mushroom

Covers the 2,830 medications we’ve checked against Lion's Mane Mushroom. Pick one to open its full report.

What to actually watch for

What Lion's Mane Mushroom Itself Has Been Linked To

This is not an interaction — nothing below involves Imiquimod. It is the side-effect record for Lion's Mane Mushroom on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Lion's Mane Mushroom, this list is the first place to look.

  • Stomach upset / Nausea Additional detail

    “Orally, lion's mane mushroom may cause gastrointestinal discomfort and nausea.”

    Lion's Mane Mushroom · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 91999. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
    2. 105546. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  • A skin rash Additional detail

    Recorded for Lion's Mane Mushroom in the same Natural Medicines adverse-effect record shown under Stomach upset / Nausea above.

Everything above comes from the Natural Medicines adverse-effect record for Lion's Mane Mushroom — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Imiquimod’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Imiquimod column appears here.

Overlapping uses

What Imiquimod Is Prescribed For, and What Lion's Mane Mushroom Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Imiquimod is a prescription medicine with approved uses on its FDA label. Lion's Mane Mushroom is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Imiquimod is prescribed for: Imiquimod cream is used to treat three skin conditions in adults: actinic keratoses (rough, scaly patches on the skin caused by sun damage) on the face or scalp; superficial basal cell carcinoma (a type of skin cancer) on the trunk, neck, or limbs when surgery is not the best option; and external genital and perianal warts (condyloma acuminata) in patients 12 years and older. It is not effective for molluscum contagiosum in children ages 2–12, and it has not been proven safe or effective in people with weakened immune systems. It should not be used for warts inside the urethra, vagina, cervix, rectum, or anal canal.

Lion's Mane Mushroom has been studied for:

  • Cancer studied, not established Lion's Mane Mushroom has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Lion's Mane Mushroom for cancer

    Although there is interest in using oral lion's mane mushroom for cancer, there is insufficient reliable information about the clinical effects of lions mane mushroom for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Imiquimod on your own; if you are taking Lion's Mane Mushroom for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Lion's Mane Mushroom or Imiquimod

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lion's Mane Mushroom or Imiquimod, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Imiquimod

This page covers Lion's Mane Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Imiquimod page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Imiquimod page

“Imiquimod (Aldara, Zyclara, Vyloma) is a cream for warts, precancerous spots, and certain skin cancers, and its supplement list is short and workable for most people. Only 3 ingredients are on file, none rated major, and all involve products applied to the skin rather than swallowed.”

Reviewed by 2 · Jul 18, 2026

Open the Imiquimod interaction page

One more smart check

Taking Lion's Mane Mushroom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,338 real supplement products containing Lion's Mane Mushroom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lion's Mane Mushroom. Even though Lion's Mane Mushroom itself has no known interaction with Imiquimod, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lion's Mane Mushroom and Imiquimod Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lion's Mane Mushroom
Top 25%

#159 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Imiquimod
Steady interest

#1,639 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lion's Mane Mushroom reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Lion's Mane Mushroom and Imiquimod records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lion's Mane Mushroom

What is Lion's Mane Mushroom?

Lion's Mane Mushroom
  • Memory and cognitive support
  • Nerve health
  • Mood and anxiety
  • Immune support
  • General wellness/antioxidant

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as a food and supplement, but talk with your pharmacist or doctor before starting it, especially if you are pregnant, breastfeeding, or have allergies.

Hericium erinaceus · Hericiaceae · Fruiting body and mycelium · Capsules, powders, tablets, tinctures, teas, and as a culinary mushroom

An interaction check asks whether these two react with each other — it does not ask whether Lion's Mane Mushroom is a good idea for someone in your situation. Here is what our Lion's Mane Mushroom record says about it on its own.

Lion's Mane Mushroom: dosing

There is no official or standardized dose for lion's mane. The amounts used in studies have varied widely depending on the form (whole mushroom, fruiting body extract, or mycelium).The best advice is to follow the directions on the product label and not to exceed them. Because products differ a lot in strength and quality, look for brands that use third-party testing.

From our Lion's Mane Mushroom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lion's Mane Mushroom monograph & all interactions
Medication

About Imiquimod Topical

What Is Imiquimod Topical Used For?

Brand names: Aldara, Zyclara, Vyloma

Imiquimod cream is used to treat three skin conditions in adults: actinic keratoses (rough, scaly patches on the skin caused by sun damage) on the face or scalp; superficial basal cell carcinoma (a type of skin cancer) on the trunk, neck, or limbs when surgery is not the best option; and external genital and perianal warts (condyloma acuminata) in patients 12 years and older.

It is not effective for molluscum contagiosum in children ages 2–12, and it has not been proven safe or effective in people with weakened immune systems. It should not be used for warts inside the urethra, vagina, cervix, rectum, or anal canal.

Most-Reported Side Effects for Imiquimod

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Erythema 183 reports
Fatigue 179 reports
Nausea 114 reports
Influenza like illness 102 reports
Application site erythema 100 reports
See full Imiquimod Topical drug information
Keep checking

Other Drugs & Lion's Mane Mushroom

Browse every other medication we’ve checked against Lion's Mane Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
327Moderate
0Minor
2,502No known interaction
327 Moderate 2,502 No interaction
Moderate

327 interactions

Showing 60 of 327 moderate interactions — see all 327 on the Lion's Mane Mushroom page.

No interaction 2,502 drugs checked — show the list

We also checked Lion's Mane Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,502 medications checked with no known interaction — see the full Lion's Mane Mushroom list.

See the full Lion's Mane Mushroom interactions page
See every supplement checked against Imiquimod, ranked by severity
Evidence & sources

Lion's Mane Mushroom References

The 6 references that drive our Lion's Mane Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lion's Mane Mushroom and Imiquimod Together: Common Questions

Is it safe to take Lion's Mane Mushroom with Imiquimod?
We do not list a known interaction between Lion's Mane Mushroom and Imiquimod. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Lion's Mane Mushroom and Imiquimod used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Lion's Mane Mushroom in each. That is a conversation for your prescriber, especially if Imiquimod is being adjusted to a target.
How was the Lion's Mane Mushroom and Imiquimod combination checked?
Interactions in our licensed database are recorded against drug classes. Imiquimod is filed under 1 classification, and Lion's Mane Mushroom has documented interactions with 3 drug classes — none of Imiquimod's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Lion's Mane Mushroom interact with any other medications?
Yes. Lion's Mane Mushroom has 327 documented drug interactions in our database — Imiquimod is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Imiquimod interact with any supplements?
Yes. Imiquimod has documented interactions with 3 supplements in our database — Lion's Mane Mushroom is not one of them. The Imiquimod interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lion's Mane Mushroom monograph Uses, safety profile, and every drug interaction in one place Imiquimod Topical drug information The full plain-English guide to this medication Imiquimod supplement interactions Every supplement checked against Imiquimod, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Imiquimod and Lion's Mane Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.