Drug & supplement interaction

Lovage + Hydralazine, Hydrochlorothiazide

Hydralazine, Hydrochlorothiazide brand names: Apresoline-Esidrix, Apresazide.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Lovage has a moderate interaction with Hydralazine, Hydrochlorothiazide. Theoretically, lovage root might interfere with diuretic therapy due to its aquaretic effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lovage and Hydralazine, Hydrochlorothiazide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

DIURETIC DRUGS

Why this applies to Hydralazine, Hydrochlorothiazide

Hydralazine, Hydrochlorothiazide falls under DIURETIC DRUGS — the group Lovage interacts with.

Theoretically, lovage root might interfere with diuretic therapy due to its aquaretic effects.
Some diuretics include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Your combo pill pairs hydralazine, which relaxes blood vessels, with hydrochlorothiazide, a water pill that helps your body get rid of extra fluid and salt. Lovage has a mild "flush the kidneys" effect of its own (what herbalists call aquaretic), so on paper it could nudge in the same direction as your diuretic. The worry isn't that lovage blocks the medicine, it's that the two together might tip you into losing a bit too much fluid.

Honestly, this is a theoretical concern based on how lovage works, not on solid human studies, so I don't want to alarm you. Splashing lovage in cooking is unlikely to matter. With concentrated capsules or the essential oil, just watch for extra dizziness, lightheadedness, or feeling dehydrated, and check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lovage Also Interacts With Other Medications

Lovage has 74 moderate known drug interactions in our database — the Hydralazine, Hydrochlorothiazide one above is one of them. If you take anything else, check it against the full list below.

Moderate 74 No known interaction 2,756 (incl. Hydralazine, Hydrochlorothiazide)
Taking anything else?

Check Another of Your Medications Against Lovage

Covers the 2,830 medications we’ve checked against Lovage. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Hydralazine, Hydrochlorothiazide

This page covers Lovage only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydralazine, Hydrochlorothiazide page lists 230 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 195 moderate · 25 minor.

From our pharmacist’s overview on the Hydralazine, Hydrochlorothiazide page

“Hydralazine with hydrochlorothiazide already pulls blood pressure down two ways, so most of the supplements on this page either push that drop further or drain more potassium and fluid than the diuretic alone would. A smaller set works against it, and a few do something stranger; calcium-rich products like dolomite can build to dangero…”

Reviewed by 2 · Jul 18, 2026

Open the Hydralazine, Hydrochlorothiazide interaction page

One more smart check

Taking Lovage as Part of a Dietary Supplement Product? Check It for Interactions

We hold 57 real supplement products containing Lovage, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lovage. Your product may carry other ingredients that interact with Hydralazine, Hydrochlorothiazide too, on top of Lovage — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lovage and Hydralazine, Hydrochlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lovage
Steady interest

#771 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydralazine, Hydrochlorothiazide
Steady interest

#1,997 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lovage

What is Lovage?

  • Digestive upset and bloating
  • Mild urinary tract flushing
  • Water retention (mild diuretic)
  • Coughs and congestion
  • Menstrual discomfort
  • Culinary flavoring

Lovage is a celery-like herb traditionally used for digestion, bloating, and as a mild diuretic to flush the urinary tract. Human evidence for these uses is very limited, and while culinary amounts are generally well tolerated, concentrated supplements and the essential oil should be used cautiously. Pregnant and breastfeeding people should avoid it.

Read the full Lovage monograph & all interactions
Keep checking

Other Drugs & Lovage

Browse every other medication we’ve checked against Lovage — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
74Moderate
0Minor
2,755No known interaction
74 Moderate 2,755 No interaction
Moderate

74 interactions

Showing 60 of 74 moderate interactions — see all 74 on the Lovage page.

No interaction 2,755 drugs checked — show the list

We also checked Lovage against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,755 medications checked with no known interaction — see the full Lovage list.

See the full Lovage interactions page
See every supplement checked against Hydralazine, Hydrochlorothiazide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Lovage monograph › Uses, safety, and every drug interaction in one place Hydralazine, Hydrochlorothiazide supplement interactions › Every supplement checked against Hydralazine, Hydrochlorothiazide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Lovage and Hydralazine, Hydrochlorothiazide Together: Common Questions

Can you take Lovage with Hydralazine, Hydrochlorothiazide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Lovage and Hydralazine, Hydrochlorothiazide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Hydralazine, Hydrochlorothiazide and Lovage?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.