Medication interaction hub

What Supplements Interact with Hydralazine, Hydrochlorothiazide?

Hydralazine, Hydrochlorothiazide brand names: Apresoline-Esidrix, Apresazide. Every interaction below applies to the brands too.

230 Interactions 10 Major 195 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated September 16, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydralazine, Hydrochlorothiazide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydralazine, Hydrochlorothiazide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Hydralazine with hydrochlorothiazide already pulls blood pressure down two ways, so most of the supplements on this page either push that drop further or drain more potassium and fluid than the diuretic alone would. A smaller set works against it, and a few do something stranger; calcium-rich products like dolomite can build to dangerous blood levels because the thiazide keeps the kidneys from clearing calcium. This combination earns genuine care, and the highest-rated entries deserve your attention before you add any of them.

Around 20 ingredients on the list add to sun sensitivity, and activated charcoal can soak up the pills before they absorb, so keep it well separated from your dose. A handful of herbs can stress the kidneys directly. Of the 230 entries on file, most (195) rate moderate, 25 minor, and ten major, and those ten are where I would start reading.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 195 Minor 25 No known interaction 1,222

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Hydralazine, Hydrochlorothiazide: Top Interactions at a Glance

The most significant Hydralazine, Hydrochlorothiazide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 230 interacting ingredients — plus 1,222 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Hydralazine, Hydrochlorothiazide + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely American Hellebore + Hydralazine, Hydrochlorothiazidei

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Hydralazine, Hydrochlorothiazidei

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Likely Tyramine + Hydralazine, Hydrochlorothiazidei

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Hydralazine, Hydrochlorothiazidei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable American Mistletoe + Hydralazine, Hydrochlorothiazidei

American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pre...

Read the full interaction Major Likelihood Probable Dolomite + Hydralazine, Hydrochlorothiazidei

Taking thiazides with dolomite might increase the risk of hypercalcemia and kidney failure.

Read the full interaction
The complete list

Every Supplement Checked Against Hydralazine, Hydrochlorothiazide

All 1,452 ingredients in our database, ranked by severity — 230 with a Hydralazine, Hydrochlorothiazide interaction on file and 1,222 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydralazine, Hydrochlorothiazide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Marshmallow with Hydralazine, Hydrochlorothiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Hydralazine, Hydrochlorothiazide answer

Can you take Chlorella with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chlorella might have additive effects with photosensitizing drugs.

Full Chlorella + Hydralazine, Hydrochlorothiazide answer

Can you take Cilantro with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that coriandrin, a constituent of cilantro, has photosensitizing effects.

Full Cilantro + Hydralazine, Hydrochlorothiazide answer

Can you take Cocoa with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cocoa with antihypertensive drugs might increase the risk of hypotension.

Full Cocoa + Hydralazine, Hydrochlorothiazide answer

Can you take Coconut Water with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coconut water with antihypertensive drugs might increase the risk of hypotension.

Full Coconut Water + Hydralazine, Hydrochlorothiazide answer

Can you take Coffee with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of hypokalemia.

Full Coffee + Hydralazine, Hydrochlorothiazide answer

Can you take Cola Nut with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using cola nut with diuretic drugs might increase the risk of hypokalemia.

Full Cola Nut + Hydralazine, Hydrochlorothiazide answer

Can you take Coleus with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hy...

Full Coleus + Hydralazine, Hydrochlorothiazide answer

Can you take Colocynth with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, colocynth might increase the risk of hypokalemia when taken with potassium-depleting diuretic drugs.

Full Colocynth + Hydralazine, Hydrochlorothiazide answer

Can you take Coltsfoot with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, excessive doses of coltsfoot may interfere with antihypertensive or cardiovascular therapy.

Full Coltsfoot + Hydralazine, Hydrochlorothiazide answer

Can you take Combretum Micranthum with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Combretum micranthum leaf with antihypertensive drugs might increase the risk of hypotension.

Full Combretum Micranthum + Hydralazine, Hydrochlorothiazide answer

Can you take Conjugated Linoleic Acid (cla) with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CLA with antihypertensive drugs might increase the risk of hypotension.

Full Conjugated Linoleic Acid (cla) + Hydralazine, Hydrochlorothiazide answer

Can you take Coriander with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.

Full Coriander + Hydralazine, Hydrochlorothiazide answer

Can you take Corn Silk with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking corn silk extract with antihypertensive drugs might increase the risk of hypotension.

Full Corn Silk + Hydralazine, Hydrochlorothiazide answer

Can you take Corydalis Yanhusuo with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might have additive effects with antihypertensive drugs.

Full Corydalis Yanhusuo + Hydralazine, Hydrochlorothiazide answer

Can you take Danshen with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking danshen with antihypertensive drugs might increase the risk of hypotension.

Full Danshen + Hydralazine, Hydrochlorothiazide answer

Can you take Diindolylmethane with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.

Full Diindolylmethane + Hydralazine, Hydrochlorothiazide answer

Can you take European Barberry with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking European barberry with antihypertensive drugs might increase the risk of hypotension.

Full European Barberry + Hydralazine, Hydrochlorothiazide answer

Can you take European Buckthorn with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. European buckthorn has stimulant laxative effects.

Full European Buckthorn + Hydralazine, Hydrochlorothiazide answer

Can you take European Mistletoe with Hydralazine, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European mistletoe might increase the risk of hypotension when taken with antihypertensive drugs.

Full European Mistletoe + Hydralazine, Hydrochlorothiazide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydralazine, Hydrochlorothiazide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydralazine, Hydrochlorothiazide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydralazine, Hydrochlorothiazide sits in 9 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Hydralazine, Hydrochlorothiazide through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Hydralazine, Hydrochlorothiazide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydralazine, Hydrochlorothiazide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydralazine, Hydrochlorothiazide through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydralazine, Hydrochlorothiazide through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Hydralazine, Hydrochlorothiazide through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydralazine, Hydrochlorothiazide through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydralazine, Hydrochlorothiazide through this category.

Vasodilators 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Hydralazine, Hydrochlorothiazide through this category.

Related: does Hydralazine, Hydrochlorothiazide deplete any nutrients?

Hydralazine, Hydrochlorothiazide has 20 reported nutrient associations in the research literature — see the Hydralazine, Hydrochlorothiazide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydralazine, Hydrochlorothiazide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydralazine, Hydrochlorothiazide.

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Pharmacist Counseling Corner

Hydralazine, Hydrochlorothiazide & Supplements: Common Questions

What supplements interact with Hydralazine, Hydrochlorothiazide?
More than you might expect — 230 in total, though they are far from equal: 10 are rated major, 195 moderate, and 25 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Hydralazine, Hydrochlorothiazide supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Hydralazine, Hydrochlorothiazide?
Usually yes — most people on Hydralazine, Hydrochlorothiazide can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Apresoline-Esidrix have the same supplement interactions as Hydralazine, Hydrochlorothiazide?
Yes — Apresoline-Esidrix, Apresazide all contain Hydralazine, Hydrochlorothiazide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydralazine, Hydrochlorothiazide deplete any vitamins or nutrients?
It might — Hydralazine, Hydrochlorothiazide has 20 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydralazine, Hydrochlorothiazide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydralazine, Hydrochlorothiazide and my other medications?
This page covers Hydralazine, Hydrochlorothiazide against supplements and herbal ingredients. Checking Hydralazine, Hydrochlorothiazide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 16, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.