Drug & supplement interaction

Mace + Betamethasone Dipropionate

Betamethasone Dipropionate brand name: Sernivo.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Mace has a moderate interaction with Betamethasone Dipropionate. Animal research suggests that mace lignans can suppress immune function.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Mace and Betamethasone Dipropionate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

IMMUNOSUPPRESSANTS

Why this applies to Betamethasone Dipropionate

Betamethasone Dipropionate falls under IMMUNOSUPPRESSANTS — the group Mace interacts with.

Animal research suggests that mace lignans can suppress immune function. Theoretically, concomitant use might enhance the effects of immunosuppressant drugs. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the good news on this one: the worry on file is about mace possibly nudging the immune system in the same direction as immunosuppressant drugs, but that idea comes only from animal lab studies, not human research. And with Sernivo (betamethasone dipropionate), this is a cream you put on your skin for things like eczema or psoriasis. Very little of it gets into your bloodstream, so a body-wide immune effect is unlikely from the topical form.

On top of that, mace used as a kitchen spice gives you tiny amounts of these compounds. So a sprinkle in your cooking shouldn't be an issue. I'd only pause on concentrated mace supplements, and even then the concern here is mostly theoretical. If you're using a strong steroid cream over large areas or for a long time, just run it by your pharmacist or doctor to be safe.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Checker R, Chatterjee S, Sharma D, et al. Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes. Int Immunopharmacol. 2008;8(5):661-669. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Mace Also Interacts With Other Medications

Mace has 499 moderate known drug interactions in our database — the Betamethasone Dipropionate one above is one of them. If you take anything else, check it against the full list below.

Moderate 499 No known interaction 2,331 (incl. Betamethasone Dipropionate)
Taking anything else?

Check Another of Your Medications Against Mace

Covers the 2,830 medications we’ve checked against Mace. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Betamethasone Dipropionate

This page covers Mace only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Betamethasone Dipropionate page lists 107 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Lily-of-the-valley (major), St. John's Wort (major), Active Hexose Correlated Compound (ahcc) (moderate), Alder Buckthorn (moderate) and Alfalfa (moderate).

By severity: 2 major · 95 moderate · 10 minor.

From our pharmacist’s overview on the Betamethasone Dipropionate page

“Betamethasone dipropionate (Sernivo) is a potent corticosteroid applied to the skin, and enough can absorb through it, especially over large areas or with long courses, that these interactions deserve genuine vigilance. Two of the 107 ingredients on file rate major: lily-of-the-valley, whose cardiac glycosides become more toxic when pr…”

Reviewed by 2 · Jul 18, 2026

Open the Betamethasone Dipropionate interaction page

One more smart check

Taking Mace as Part of a Dietary Supplement Product? Check It for Interactions

We hold 38 real supplement products containing Mace, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Mace. Your product may carry other ingredients that interact with Betamethasone Dipropionate too, on top of Mace — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Mace and Betamethasone Dipropionate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mace
Steady interest

#728 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Betamethasone Dipropionate
Top 25%

#561 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Mace

What is Mace?

  • Digestive upset and gas
  • Flavoring and culinary spice
  • Nausea
  • Appetite stimulation
  • Traditional pain or muscle relief

Mace is the lacy red covering of the nutmeg seed and comes from the same tree as nutmeg. It is mostly used as a cooking spice and in traditional medicine for digestion, but there is little solid human research to support its health uses. In normal food amounts it is generally safe, but large doses can be toxic, so use it as a spice and check with your pharmacist before taking concentrated supplements.

Read the full Mace monograph & all interactions
Medication

About Betamethasone Topical

What Is Betamethasone Topical Used For?

Brand name: Sernivo

Betamethasone topical is used to relieve the redness, swelling, and itching of corticosteroid-responsive dermatoses (skin conditions that respond to steroid treatment). Sernivo Spray is specifically approved for plaque psoriasis of the body. Diprolene (topical cream, ointment, or gel) is indicated for inflammatory and itchy skin conditions in patients 13 years of age and older.

This medication is for use on the skin only. It is not approved for use on the face, groin, or underarms, and it is not for use in the eyes, mouth, or vagina.

See full Betamethasone Topical drug information
Keep checking

Other Drugs & Mace

Browse every other medication we’ve checked against Mace — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
499Moderate
0Minor
2,330No known interaction
499 Moderate 2,330 No interaction
Moderate

499 interactions

Showing 60 of 499 moderate interactions — see all 499 on the Mace page.

No interaction 2,330 drugs checked — show the list

We also checked Mace against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,330 medications checked with no known interaction — see the full Mace list.

See the full Mace interactions page
See every supplement checked against Betamethasone Dipropionate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Mace monograph › Uses, safety, and every drug interaction in one place Betamethasone Dipropionate supplement interactions › Every supplement checked against Betamethasone Dipropionate, ranked by severity Betamethasone Topical drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Mace and Betamethasone Dipropionate Together: Common Questions

Can you take Mace with Betamethasone Dipropionate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Mace and Betamethasone Dipropionate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Betamethasone Dipropionate and Mace?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.