Drug & supplement interaction

Maral Root + Clonidine

Clonidine brand name: Catapres.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Maral Root and Clonidine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Maral Root and Clonidine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Clonidine and Maral Root in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Maral Root safety at a glance

Maral Root overall Use caution Limited human safety data, so use carefully and under professional guidance.
Pregnancy Avoid Not enough safety information; avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Clonidine and Maral Root? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Clonidine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Clonidine is filed under 4 classifications — including alpha-adrenergic agonists, antihypertensive drugs, oral drugs. Maral Root has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Clonidine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Maral Root Does Interact With Other Medications

Maral Root has 122 moderate known drug interactions in our database — Clonidine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Clonidine)
Taking anything else?

Check Another of Your Medications Against Maral Root

Covers the 2,830 medications we’ve checked against Maral Root. Pick one to open its full report.

What to actually watch for

What Clonidine’s Own FDA Label Lists

This is not an interaction — none of it involves Maral Root. These are the most notable effects listed in the ADVERSE REACTIONS section of Clonidine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 4 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Hallucinations Worth acting on
  • Raised blood pressure Worth acting on mentioned in 5.7% of FDA reports for Clonidine
  • An allergic reaction Worth acting on
  • Vivid dreams or nightmares
  • Mood changes or irritability
  • Tremor or shakiness
  • A stuffy or runny nose
  • Dry mouth
  • A fast or pounding heartbeat

Showing the 10 most notable of 21 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Clonidine. Read the label on DailyMed › Where a percentage is shown, it is the share of 57,112 voluntary FDA FAERS reports for Clonidine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Maral Root’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Maral Root side to compare — that is a limit of the record, not a statement that Maral Root has no side effects.

From our Q&A

Questions About Maral Root or Clonidine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Maral Root or Clonidine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Clonidine

This page covers Maral Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clonidine page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 113 moderate · 21 minor.

From our pharmacist’s overview on the Clonidine page

“American hellebore is the ingredient I would want a clonidine (Catapres) patient to know about first. Its alkaloids lower blood pressure even in small doses and slow the heart, both things clonidine already does, so the combination can drop someone dangerously low.”

Reviewed by 2 · Jul 18, 2026

Open the Clonidine interaction page

One more smart check

Taking Maral Root as Part of a Dietary Supplement Product? Check It for Interactions

We hold 82 real supplement products containing Maral Root, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Maral Root. Even though Maral Root itself has no known interaction with Clonidine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Maral Root and Clonidine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Maral Root
Top half

#582 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Clonidine
Steady interest

#1,512 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Maral Root reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Maral Root and Clonidine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Maral Root

What is Maral Root?

  • Physical performance and stamina
  • Muscle building
  • Fatigue and recovery
  • Stress and adaptation
  • General energy and vitality

Maral Root (Rhaponticum carthamoides) is a Siberian herb used as an 'adaptogen' and is popular among athletes for stamina and muscle building, largely because it contains plant compounds called ecdysteroids. Human evidence is very limited, so its benefits remain mostly unproven. Talk with a pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a health condition.

Rhaponticum carthamoides · Asteraceae · Root and rhizome · Capsules, tablets, powder, liquid extract/tincture, tea

An interaction check asks whether these two react with each other — it does not ask whether Maral Root is a good idea for someone in your situation. Here is what our Maral Root record says about it on its own.

Maral Root: dosing

There is no officially established standard dose for Maral Root. Products vary widely in their strength and how much active compound they contain.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Maral Root monograph — the full record covers uses, side effects and every documented interaction.

Read the full Maral Root monograph & all interactions
Medication

About Clonidine

What Is Clonidine Used For?

Brand name: Catapres

Clonidine is used to treat high blood pressure (hypertension). Several products — including Clonidine Hydrochloride tablets, Javadin oral solution, Nexiclon XR extended-release tablets, and Catapres-TTS skin patches — are approved for this use, either alone or combined with other blood pressure medicines.

Extended-release formulations — including Onyda XR oral suspension and clonidine hydrochloride extended-release tablets (such as Kapvay) — are approved to treat ADHD in children and teenagers ages 6 to 17, either on their own or alongside stimulant medications. Separately, clonidine injection products (Duraclon and others) are used alongside opioid pain medicines to treat severe cancer pain that opioids alone cannot control adequately.

Most-Reported Side Effects for Clonidine

From FAERS, the FDA’s public side-effect reporting system (57,112 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 3,519 reports
Nausea 3,475 reports
Headache 3,432 reports
Hypertension 3,275 reports
Dyspnea 2,748 reports
See full Clonidine drug information
Keep checking

Other Drugs & Maral Root

Browse every other medication we’ve checked against Maral Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Maral Root page.

No interaction 2,707 drugs checked — show the list

We also checked Maral Root against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Maral Root list.

See the full Maral Root interactions page
See every supplement checked against Clonidine, ranked by severity
Evidence & sources

Maral Root References

The 2 references that drive our Maral Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Koleckar V, Brojerova E, Rehakova Z, et al. In vitro antiplatelet activity of flavonoids from Leuzea carthamoides. Drug Chem Toxicol 2008;31(1):27-35.
  2. Ryan ED, Gerstner GR, Mota JA, et al. The Acute Effects of a Multi-Ingredient Herbal Supplement on Performance Fatigability: A Double-Blind, Randomized, and Placebo-Controlled Trial. J Diet Suppl 2021;18(5):507-516. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Maral Root and Clonidine Together: Common Questions

Is it safe to take Maral Root with Clonidine?
We do not list a known interaction between Maral Root and Clonidine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Maral Root and Clonidine combination checked?
Interactions in our licensed database are recorded against drug classes. Clonidine is filed under 4 classifications, and Maral Root has documented interactions with 1 drug class — none of Clonidine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Maral Root interact with any other medications?
Yes. Maral Root has 122 documented drug interactions in our database — Clonidine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Clonidine interact with any supplements?
Yes. Clonidine has documented interactions with 138 supplements in our database — Maral Root is not one of them. The Clonidine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Maral Root monograph Uses, safety profile, and every drug interaction in one place Clonidine drug information The full plain-English guide to this medication Clonidine supplement interactions Every supplement checked against Clonidine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Clonidine and Maral Root?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.