Drug & supplement interaction

Noni + Vericiguat

Vericiguat brand name: Verquvo.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Noni and Vericiguat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Vericiguat states a food rule worth keeping to.

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Interaction report

Noni and Vericiguat

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Vericiguat and Noni in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Noni safety at a glance

Noni overall Use caution Generally tolerated in moderate amounts, but rare liver injury and high potassium content are concerns.
Pregnancy Avoid Traditionally used to cause abortion, so it should not be used during pregnancy.
Breastfeeding Avoid Not enough safety information is available, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Vericiguat and Noni? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Vericiguat

Interactions in our licensed database are recorded against drug classes, not just single drug names. Vericiguat is filed under 2 classifications — p-glycoprotein substrates, oral drugs. Noni has documented interactions with 8 drug classes — the most serious being ace inhibitors (aceis) (moderate), angiotensin receptor blockers (arbs) (moderate) and antihypertensive drugs (moderate) — and none of Vericiguat’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Noni Does Interact With Other Medications

Noni has 541 moderate, 1 minor known drug interactions in our database — Vericiguat isn’t one of them. If you take anything else, check it against the full list below.

Moderate 541 Minor 1 No known interaction 2,288 (incl. Vericiguat)
Taking anything else?

Check Another of Your Medications Against Noni

Covers the 2,830 medications we’ve checked against Noni. Pick one to open its full report.

What to actually watch for

What Noni Itself Has Been Linked To

This is not an interaction — nothing below involves Vericiguat. It is the side-effect record for Noni on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Noni, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    “Noni has been associated with several cases of hepatotoxicity in previously healthy patients ranging in age from 14 to 62 years. In two cases, the patients had used a tea or other herbal products containing noni; five had consumed noni juice, specifically Tahitian Noni Juice (Tahitian Noni International); and two cases involved energy drinks containing several herbal ingredients including noni.”

    Noni · Natural Medicines adverse-effect record, reported in cholestasis.

    6 sources cited
    1. 13107. Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-7. PubMed
    2. 14341. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
    3. 14468. Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-70.
    4. 17170. Yu EL, Sivagnanam M, Ellis L, Huang JS. Acute hepatotoxicity after ingestion of Morinda citrifolia (noni berry) juice in a 14-year-old boy. J Pediatr Gastroenterol Nutr 2011;52:222-4.
    5. 17171. Stadlbauer V, Weiss S, Payer F, Stauber RE. Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia (noni). Am J Gastroenterol 2008;103:2406-7. PubMed
    6. 17172. López-Cepero Andrada JM, Lerma Castilla S, Fernández Olvera MD, Amaya Vidal A. [Hepatotoxicity caused by a noni (Morinda citrifolia) preparation]. [Article in Spanish] Rev Esp Enferm Dig 2007;99:179-81.
  • Stomach upset / Nausea Additional detail

    “Orally, dehydrated noni fruit has been reported to cause nausea and abdominal discomfort.”

    Noni · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 65173. Issell, B. F., Gotay, C. C., Pagano, I., and Franke, A. A. Using quality of life measures in a Phase I clinical trial of noni in patients with advanced cancer to select a Phase II dose. J.Diet.Suppl 2009;6(4):347-359. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Noni — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Vericiguat’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Vericiguat column appears here.

How to take them

Some Vericiguat Products Have a Food Rule — Noni Should Not Break It

At least one FDA label for a product containing Vericiguat says to take it with food. If you take Noni on an empty stomach out of habit, keep them separate — and take Vericiguat with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Vericiguat products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION The recommended starting dose of VERQUVO is 5 mg orally once daily with food.

From the Dosage and Administration section of the FDA label we read for Vericiguat — where that label names a specific product, the instruction is that product's. See the Vericiguat drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Vericiguat

This page covers Noni only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Vericiguat page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 35 moderate · 17 minor.

From our pharmacist’s overview on the Vericiguat page

“No supplement on this page worries me more for vericiguat (Verquvo) users than St. John's wort.”

Reviewed by 2 · Jul 18, 2026

Open the Vericiguat interaction page

One more smart check

Taking Noni as Part of a Dietary Supplement Product? Check It for Interactions

We hold 727 real supplement products containing Noni, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Noni. Even though Noni itself has no known interaction with Vericiguat, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Noni and Vericiguat Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Noni
Top 25%

#311 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Vericiguat
Steady interest

#2,656 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Noni reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Noni and Vericiguat records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Noni

What is Noni?

Noni
  • General wellness and energy
  • Inflammation and joint pain
  • Immune support
  • High blood pressure
  • Skin and wound care
  • Digestive complaints

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits is limited. While moderate juice intake is generally well tolerated, there are rare reports of liver problems, and it should be avoided in pregnancy and breastfeeding. Talk with your pharmacist or doctor before using it, especially if you have kidney or liver disease.

Morinda citrifolia · Rubiaceae · Fruit (most common), but also leaves, roots, bark, stem, and flowers · Juice, capsules, tablets, powders, teas, and topical products

An interaction check asks whether these two react with each other — it does not ask whether Noni is a good idea for someone in your situation. Here is what our Noni record says about it on its own.

Noni: dosing

There is no officially established or standardized dose for noni. Products vary widely in strength and form, including juice, capsules, and powders.Commercial noni juices are often consumed in small daily amounts, but the right amount depends on the specific product. The safest approach is to follow the directions on the product label and not exceed the suggested amount.Because supplements are not tightly regulated, quality and purity can differ between brands.

From our Noni monograph — the full record covers uses, side effects and every documented interaction.

Read the full Noni monograph & all interactions
Medication

About Vericiguat

What Is Vericiguat Used For?

Brand name: Verquvo

Verquvo (vericiguat) is used to reduce the risk of cardiovascular death and hospitalization due to heart failure. It is specifically for adults with symptomatic chronic heart failure whose heart pumps with reduced function (ejection fraction less than 45%), following a recent hospitalization for heart failure or a need for IV diuretics given outside the hospital.

Verquvo is taken on top of other standard heart failure treatments — it is not a replacement for them.

Most-Reported Side Effects for Vericiguat

From FAERS, the FDA’s public side-effect reporting system (966 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hypotension 111 reports
Cardiac failure 72 reports
Dizziness 68 reports
Anemia 40 reports
Blood pressure decreased 40 reports
See full Vericiguat drug information
Keep checking

Other Drugs & Noni

Browse every other medication we’ve checked against Noni — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
541Moderate
1Minor
2,287No known interaction
541 Moderate 1 Minor 2,287 No interaction
Moderate

541 interactions

Showing 60 of 541 moderate interactions — see all 541 on the Noni page.

Minor

1 interaction

No interaction 2,287 drugs checked — show the list

We also checked Noni against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,287 medications checked with no known interaction — see the full Noni list.

See the full Noni interactions page
See every supplement checked against Vericiguat, ranked by severity
Evidence & sources

Noni References

The 16 references that drive our Noni monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia): hidden potential for hyperkalemia? Am J Kidney Dis 2000;35:310-2. PubMed
  2. Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-7. PubMed
  3. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
  4. Carr ME, Klotz J, Bergeron M. Coumadin resistance and the vitamin supplement "Noni". Am J Hematol 2004;77:103. PubMed
  5. Jensen CJ, Westendorf J, Wang MY, Wadsworth DP. Noni juice protects the liver. Eur J Gastroenterol Hepatol 2006;18:575-7. PubMed
  6. Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-70.
  7. Koch E, Biber A. Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin. Phytomedicine 2007;14 Suppl 6:40-5. PubMed
  8. Yu EL, Sivagnanam M, Ellis L, Huang JS. Acute hepatotoxicity after ingestion of Morinda citrifolia (noni berry) juice in a 14-year-old boy. J Pediatr Gastroenterol Nutr 2011;52:222-4.
  9. Stadlbauer V, Weiss S, Payer F, Stauber RE. Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia (noni). Am J Gastroenterol 2008;103:2406-7. PubMed
  10. López-Cepero Andrada JM, Lerma Castilla S, Fernández Olvera MD, Amaya Vidal A. [Hepatotoxicity caused by a noni (Morinda citrifolia) preparation]. [Article in Spanish] Rev Esp Enferm Dig 2007;99:179-81.
  11. Nima S, Kasiwong S, Ridtitid W, et al. Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models. J Ethnopharmacol. 2012;142(2):354-61. PubMed
  12. Issell, B. F., Gotay, C. C., Pagano, I., and Franke, A. A. Using quality of life measures in a Phase I clinical trial of noni in patients with advanced cancer to select a Phase II dose. J.Diet.Suppl 2009;6(4):347-359. PubMed
  13. Palu AK, Santiago RA West B Kaluhiokalani N Jensen J. The Effects of Morillda citrifolia L. Noni on High Blood Pressure: A Mechanistic Investigation and Case Study. ACS SYMPOSIUM SERIES 993 2008;
  14. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  15. Bussmann RW, Hennig L, Giannis A, Ortwein J, Kutchan TM, Feng X. Anthraquinone Content in Noni (Morinda citrifolia L.). Evid Based Complement Alternat Med. 2013;2013:208378.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Noni and Vericiguat Together: Common Questions

Is it safe to take Noni with Vericiguat?
We do not list a known interaction between Noni and Vericiguat. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Noni and Vericiguat at the same time of day?
At least one FDA label for a product containing Vericiguat says to take it with food. If you take Noni on an empty stomach out of habit, keep them separate and take Vericiguat with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Vericiguat products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Noni and Vericiguat combination checked?
Interactions in our licensed database are recorded against drug classes. Vericiguat is filed under 2 classifications, and Noni has documented interactions with 8 drug classes — none of Vericiguat's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Noni interact with any other medications?
Yes. Noni has 542 documented drug interactions in our database — Vericiguat is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Vericiguat interact with any supplements?
Yes. Vericiguat has documented interactions with 54 supplements in our database — Noni is not one of them. The Vericiguat interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Noni monograph Uses, safety profile, and every drug interaction in one place Vericiguat drug information The full plain-English guide to this medication Vericiguat supplement interactions Every supplement checked against Vericiguat, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 16 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Vericiguat and Noni?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.