Drug & supplement interaction

Rabdosia Rubescens + Promethazine, Pseudoephedrine

Promethazine, Pseudoephedrine brand name: Phenergan D.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Rabdosia Rubescens and Promethazine, Pseudoephedrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Rabdosia Rubescens and Promethazine, Pseudoephedrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Promethazine, Pseudoephedrine and Rabdosia Rubescens in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rabdosia Rubescens safety at a glance

Rabdosia Rubescens overall Use caution Human safety data are limited, so use carefully and under professional guidance.
Pregnancy Avoid Not enough safety information exists, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety data while breastfeeding, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Promethazine, Pseudoephedrine and Rabdosia Rubescens? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Promethazine, Pseudoephedrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Promethazine, Pseudoephedrine is filed under 7 classifications — including phenothiazines, alpha-adrenergic agonists, stimulant drugs. Rabdosia Rubescens has documented interactions with 3 drug classes — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (moderate), p-glycoprotein substrates (moderate) and cytochrome p450 2c9 (cyp2c9) substrates (minor) — and none of Promethazine, Pseudoephedrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rabdosia Rubescens Does Interact With Other Medications

Rabdosia Rubescens has 714 moderate, 69 minor known drug interactions in our database — Promethazine, Pseudoephedrine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 714 Minor 69 No known interaction 2,047 (incl. Promethazine, Pseudoephedrine)
Taking anything else?

Check Another of Your Medications Against Rabdosia Rubescens

Covers the 2,830 medications we’ve checked against Rabdosia Rubescens. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Promethazine, Pseudoephedrine

This page covers Rabdosia Rubescens only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Promethazine, Pseudoephedrine page lists 116 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Henbane (major), Peyote (major) and Rauvolfia Vomitoria (major).

By severity: 7 major · 93 moderate · 16 minor.

From our pharmacist’s overview on the Promethazine, Pseudoephedrine page

“Phenergan D combines a sedating antihistamine, promethazine, with the decongestant stimulant pseudoephedrine, and its supplement list pulls hard in both directions, so this is one to treat with genuine care. The biggest cluster, from everyday caffeine sources like coffee and cola nut up to ephedra, stacks extra stimulation on the pseud…”

Reviewed by 2 · Jul 18, 2026

Open the Promethazine, Pseudoephedrine interaction page

How much people look this up

Where Rabdosia Rubescens and Promethazine, Pseudoephedrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rabdosia Rubescens
Steady interest

#947 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Promethazine, Pseudoephedrine
Top 25%

#457 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rabdosia Rubescens reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Rabdosia Rubescens and Promethazine, Pseudoephedrine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rabdosia Rubescens

What is Rabdosia Rubescens?

Rabdosia Rubescens
  • Sore throat and respiratory complaints
  • Inflammation
  • Antimicrobial support
  • Digestive complaints
  • Traditional cancer support

Rabdosia rubescens is a Chinese herb traditionally used for sore throats, inflammation, and infections, and its compound oridonin has drawn lab interest for possible anticancer effects. However, strong human evidence is lacking for any use, and safety has not been well studied, so talk with your pharmacist or doctor before trying it.

Rabdosia rubescens · Lamiaceae · Aerial parts (leaves and stems) · Capsules, tablets, powders, teas, and liquid extracts

An interaction check asks whether these two react with each other — it does not ask whether Rabdosia Rubescens is a good idea for someone in your situation. Here is what our Rabdosia Rubescens record says about it on its own.

Rabdosia Rubescens: dosing

There is no well-established, standardized dose for Rabdosia rubescens. Studies have used different forms and amounts, so there is no agreed-upon safe and effective dose for any condition.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount.

From our Rabdosia Rubescens monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rabdosia Rubescens monograph & all interactions
Keep checking

Other Drugs & Rabdosia Rubescens

Browse every other medication we’ve checked against Rabdosia Rubescens — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
714Moderate
69Minor
2,046No known interaction
714 Moderate 69 Minor 2,046 No interaction
Moderate

714 interactions

Showing 60 of 714 moderate interactions — see all 714 on the Rabdosia Rubescens page.

Minor

69 interactions

Showing 60 of 69 minor interactions — see all 69 on the Rabdosia Rubescens page.

No interaction 2,046 drugs checked — show the list

We also checked Rabdosia Rubescens against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,046 medications checked with no known interaction — see the full Rabdosia Rubescens list.

See the full Rabdosia Rubescens interactions page
See every supplement checked against Promethazine, Pseudoephedrine, ranked by severity
Evidence & sources

Rabdosia Rubescens References

The 3 references that drive our Rabdosia Rubescens monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chen S, Liu J, Zhang H. Efficacy of rabdosia rubescens in the treatment of gingivitis. J Huazhong Univ Sci Technolog Med Sci. 2009;29(5):659-63. PubMed
  2. Zhang YW, Zheng XW, Liu YJ, et al. Effect of oridonin on cytochrome P450 expression and activities in HepaRG Cell. Pharmacology. 2018;101(5-6):246-254. PubMed
  3. Li F, Fan J, Wu Z, et al. Reversal effects of Rabdosia rubescens extract on multidrug resistance of MCF-7/Adr cells in vitro. Pharm Biol. 2013;51(9):1196-203.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rabdosia Rubescens and Promethazine, Pseudoephedrine Together: Common Questions

Is it safe to take Rabdosia Rubescens with Promethazine, Pseudoephedrine?
We do not list a known interaction between Rabdosia Rubescens and Promethazine, Pseudoephedrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Rabdosia Rubescens and Promethazine, Pseudoephedrine combination checked?
Interactions in our licensed database are recorded against drug classes. Promethazine, Pseudoephedrine is filed under 7 classifications, and Rabdosia Rubescens has documented interactions with 3 drug classes — none of Promethazine, Pseudoephedrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rabdosia Rubescens interact with any other medications?
Yes. Rabdosia Rubescens has 783 documented drug interactions in our database — Promethazine, Pseudoephedrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Promethazine, Pseudoephedrine interact with any supplements?
Yes. Promethazine, Pseudoephedrine has documented interactions with 116 supplements in our database — Rabdosia Rubescens is not one of them. The Promethazine, Pseudoephedrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rabdosia Rubescens monograph Uses, safety profile, and every drug interaction in one place Promethazine, Pseudoephedrine supplement interactions Every supplement checked against Promethazine, Pseudoephedrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.