Drug & supplement interaction

Schisandra + Cefdinir

Cefdinir brand name: Omnicef.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Schisandra and Cefdinir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Schisandra and Cefdinir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cefdinir and Schisandra in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Schisandra safety at a glance

Schisandra overall Use caution Generally well tolerated short term in healthy adults, but high-quality safety data are limited.
Pregnancy Possibly Unsafe When used orally. Some evidence suggests schisandra fruit is a uterine stimulant. Read the full pregnancy detail
Breastfeeding Avoid There is not enough reliable safety information, so avoid it while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cefdinir and Schisandra? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cefdinir

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cefdinir is filed under 6 classifications — including organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates, antibiotic drugs. Schisandra has documented interactions with 12 drug classes — the most serious being cyclophosphamide (moderate), cyclosporine (neoral, sandimmune) (moderate) and cytochrome p450 2c19 (cyp2c19) substrates (moderate) — and none of Cefdinir’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Schisandra Does Interact With Other Medications

Schisandra has 803 moderate known drug interactions in our database — Cefdinir isn’t one of them. If you take anything else, check it against the full list below.

Moderate 803 No known interaction 2,027 (incl. Cefdinir)
Taking anything else?

Check Another of Your Medications Against Schisandra

Covers the 2,830 medications we’ve checked against Schisandra. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Schisandra and Cefdinir May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Reduced appetite / Stomach upset Additional detail

    Schisandra

    “Orally, schisandra can cause heartburn, decreased appetite, and stomach upset (11).”

    Schisandra · Natural Medicines adverse-effect record, reported in dyspepsia.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    Cefdinir

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefdinir. Read the label on DailyMed ›

Reported for Schisandra but not commonly for Cefdinir: heartburn and hives.

Effects for Cefdinir come from the ADVERSE REACTIONS section of its FDA label; effects for Schisandra come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 7,629 voluntary FDA FAERS reports for Cefdinir that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Schisandra in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Some evidence suggests schisandra fruit is a uterine stimulant.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Cefdinir Is Prescribed For, and What Schisandra Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Cefdinir is a prescription medicine with approved uses on its FDA label. Schisandra is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Cefdinir is prescribed for: Cefdinir treats mild to moderate bacterial infections in adults, adolescents, and children caused by susceptible bacteria. It is used for community-acquired pneumonia, acute exacerbations of chronic bronchitis, acute maxillary sinusitis (sinus infection), pharyngitis/tonsillitis (strep throat), and uncomplicated skin and skin structure infections. In pediatric patients (ages 6 months through 12 years), cefdinir is also used to treat acute bacterial otitis media (middle ear infection). It should only be used for infections that are proven or strongly suspected to be caused by bacteria — not for viral illnesses like the common cold.

Schisandra has been studied for:

  • Pneumonia studied, not established Schisandra has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Schisandra for pneumonia

    Oral schisandra has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Cefdinir on your own; if you are taking Schisandra for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Schisandra or Cefdinir

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Schisandra or Cefdinir, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Cefdinir

This page covers Schisandra only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cefdinir page lists 60 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 46 moderate · 11 minor.

From our pharmacist’s overview on the Cefdinir page

“Cefdinir (Omnicef) is a short-course antibiotic for ear, sinus, throat, and skin infections, and three of its 60 supplement interactions on file are rated major and deserve genuine care. Two herbs, Siberian cocklebur and asarabacca, can damage the kidneys, an added strain nobody needs while fighting an infection.”

Reviewed by 2 · Jul 18, 2026

Open the Cefdinir interaction page

One more smart check

Taking Schisandra as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,577 real supplement products containing Schisandra, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Schisandra. Even though Schisandra itself has no known interaction with Cefdinir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Schisandra and Cefdinir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Schisandra
Top 10%

#95 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cefdinir
Top half

#1,357 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Schisandra reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Schisandra and Cefdinir records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Schisandra

What is Schisandra?

Schisandra
  • Fatigue and low energy
  • Stress and adaptogen support
  • Liver health
  • Mental focus and performance
  • Menopause symptoms
  • Respiratory complaints

Schisandra is a traditional Chinese medicine berry used as an adaptogen for stress, fatigue, and liver support. Human evidence is limited and most claims are not well proven, but it appears reasonably well tolerated by most healthy adults when used short term. Pregnant and breastfeeding people should avoid it, and anyone with a health condition should check with a pharmacist or doctor first.

Schisandra chinensis · Schisandraceae · Dried ripe fruit (berries) · Capsules, tablets, dried berries, tea, tinctures, liquid extracts, powders

An interaction check asks whether these two react with each other — it does not ask whether Schisandra is a good idea for someone in your situation. Here is what our Schisandra record says about it on its own.

Schisandra: dosing

There is no official, well-established standard dose of schisandra. The right amount depends on the product, the form (berries, extract, tincture, or capsule), and how it is standardized.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Schisandra monograph — the full record covers uses, side effects and every documented interaction.

Read the full Schisandra monograph & all interactions
Medication

About Cefdinir

What Is Cefdinir Used For?

Brand name: Omnicef

Cefdinir treats mild to moderate bacterial infections in adults, adolescents, and children caused by susceptible bacteria. It is used for community-acquired pneumonia, acute exacerbations of chronic bronchitis, acute maxillary sinusitis (sinus infection), pharyngitis/tonsillitis (strep throat), and uncomplicated skin and skin structure infections.

In pediatric patients (ages 6 months through 12 years), cefdinir is also used to treat acute bacterial otitis media (middle ear infection). It should only be used for infections that are proven or strongly suspected to be caused by bacteria — not for viral illnesses like the common cold.

Most-Reported Side Effects for Cefdinir

From FAERS, the FDA’s public side-effect reporting system (7,629 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 530 reports
Chronic kidney disease 485 reports
Pneumonia 482 reports
Fatigue 462 reports
Nausea 400 reports
See full Cefdinir drug information
Keep checking

Other Drugs & Schisandra

Browse every other medication we’ve checked against Schisandra — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
803Moderate
0Minor
2,026No known interaction
803 Moderate 2,026 No interaction
Moderate

803 interactions

Showing 60 of 803 moderate interactions — see all 803 on the Schisandra page.

No interaction 2,026 drugs checked — show the list

We also checked Schisandra against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,026 medications checked with no known interaction — see the full Schisandra list.

See the full Schisandra interactions page
See every supplement checked against Cefdinir, ranked by severity
Evidence & sources

Schisandra References

The 26 references that drive our Schisandra monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Iwata H, Tezuka Y, Kadota S, et al. Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Drug Metab Dispos 2004;32:1351-8. PubMed
  3. Mu Y, Zhang J, Zhang S, et al. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. J Pharmacol Exp Ther 2006;316:1369-77. PubMed
  4. Xin HW, Wu XC, Li Q, et al. Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers. Br J Clin Pharmacol 2007;64:469-75.
  5. Qin XL, Bi HC, Wang XD, et al. Mechanistic understanding of the different effects of Wuhzi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of tacrolimus (FK506). Int J Pharm 2010;389:114-21.
  6. Makino, T., Mizuno, F., and Mizukami, H. Does a kampo medicine containing schisandra fruit affect pharmacokinetics of nifedipine like grapefruit juice? Biol.Pharm.Bull. 2006;29(10):2065-2069. PubMed
  7. Fan L, Mao XQ, Tao GY, Wang G, Jiang F, Chen Y, Li Q, Zhang W, Lei HP, Hu DL, Huang YF, Wang D, Zhou HH. Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers. Xenobiotica. 2009 Mar;39(
  8. Jiang W, Wang X, Xu X, Kong L. Effect of Schisandra sphenanthera extract on the concentration of tacrolimus in the blood of liver transplant patients. Int J Clin Pharmacol Ther. 2010 Mar;48(3):224-9. PubMed
  9. Xin HW, Wu XC, Li Q, Yu AR, Xiong L. Effects of Schisandra sphenanthera extract on the pharmacokinetics of midazolam in healthy volunteers. Br J Clin Pharmacol. 2009 May;67(5):541-6.
  10. Li J, Chen S, Qin X, et at. Wuzhi Tablet (<i>Schisandra sphenanthera</i> Extract) is a Promising Tacrolimus-Sparing Agent for Renal Transplant Recipients Who are CYP3A5 Expressers: a Two-Phase Prospective Study. Drug Metab Dispos. 2017;45(11):1114-1119.
  11. Qin XL, Li JL, Wang SH, Chen X, Huang M, Bi HC. Co-administration of Wuzhi tablet (Schisandra sphenanthera extract) alters tacrolimus pharmacokinetics in a dose- and time-dependent manner in rats. J Ethnopharmacol. 2020;263:113233. PubMed
  12. Yuan F, Liang X, Chen X, Qin X, Tan C, Wang L. CYP2C19 is involved in the effect of Wuzhi tablet (Schisandra sphenanthera extract) and its constituents on the pharmacokinetics of intravenous voriconazole. Pharmazie. 2020;75(11):559-564. DOI
  13. Zhang Z, Lu X, Dong L, Ma J, Fan X. Clinical observation on the effect of Wuzhi soft capsule on FK506 concentration in membranous nephropathy patients. Medicine (Baltimore). 2019;98(48):e18150. PubMed
  14. Yoo HH, Lee M, Lee MW, Lim SY, Shin J, Kim DH. Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2. Planta Med. 2007;73(5):444-50.
  15. Qiangrong P, Wang T, Lu Q, Hu X. Schisandrin B--a novel inhibitor of P-glycoprotein. Biochem Biophys Res Commun. 2005;335(2):406-11. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Schisandra and Cefdinir Together: Common Questions

Is it safe to take Schisandra with Cefdinir?
We do not list a known interaction between Schisandra and Cefdinir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Schisandra and Cefdinir have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Schisandra and Cefdinir used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Schisandra in each. That is a conversation for your prescriber, especially if Cefdinir is being adjusted to a target.
How was the Schisandra and Cefdinir combination checked?
Interactions in our licensed database are recorded against drug classes. Cefdinir is filed under 6 classifications, and Schisandra has documented interactions with 12 drug classes — none of Cefdinir's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Schisandra interact with any other medications?
Yes. Schisandra has 803 documented drug interactions in our database — Cefdinir is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cefdinir interact with any supplements?
Yes. Cefdinir has documented interactions with 60 supplements in our database — Schisandra is not one of them. The Cefdinir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Schisandra monograph Uses, safety profile, and every drug interaction in one place Cefdinir drug information The full plain-English guide to this medication Cefdinir supplement interactions Every supplement checked against Cefdinir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 26 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cefdinir and Schisandra?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.