Tinospora Cordifolia + Amitriptyline, Chlordiazepoxide
Amitriptyline, Chlordiazepoxide brand name: Limbitrol DS.
Amitriptyline, Chlordiazepoxide falls into 4 drug categories that Tinospora Cordifolia can interact with; the most serious is rated moderate. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
Read the full interaction reportTinospora Cordifolia and Amitriptyline, Chlordiazepoxide
These two interact in 4 distinct ways. Each one is explained separately below.
Why Are There 4 Interactions?
Tinospora Cordifolia interacts with whole categories of medication. Amitriptyline, Chlordiazepoxide falls into 4 of those categories, so it can interact with Tinospora Cordifolia in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
1 of 4Why this applies to Amitriptyline, Chlordiazepoxide
Amitriptyline, Chlordiazepoxide falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Tinospora Cordifolia interacts with.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2D6 at high concentrations. However, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Limbitrol DS combines amitriptyline (a tricyclic antidepressant) with chlordiazepoxide (a calming benzodiazepine). The amitriptyline part is partly cleared by a liver enzyme called CYP2D6. In the lab, Tinospora cordifolia (Giloy) has slowed that same enzyme, but only at high concentrations and never in actual people. So this is a theoretical concern based on test-tube work, not something that's been seen in real life.
If it did happen, amitriptyline could build up a bit, which might mean more drowsiness, dry mouth, constipation, dizziness, or a faster heartbeat. The evidence here is weak, so I wouldn't panic. Still, before adding Giloy, run it by your pharmacist or doctor, especially since this supplement has been linked to liver injury.
- Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES
2 of 4Amitriptyline, Chlordiazepoxide also falls under CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C19 at high concentrations. However, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Limbitrol DS combines amitriptyline (an antidepressant) with chlordiazepoxide (a benzodiazepine for anxiety). Your body uses several liver enzymes to clear these, and one of them is CYP2C19. Lab tests hint that Tinospora cordifolia (Giloy) can slow that enzyme down, which in theory could let a bit more of these drugs build up in your system.
If that happened, you might notice stronger versions of the usual effects: extra drowsiness, dizziness, dry mouth, constipation, or feeling foggy. Here's the honest part though, this is only based on test-tube research at high concentrations and hasn't been seen in real people. I wouldn't lose sleep over it, but since this combo already causes sedation, it's worth a quick chat with your pharmacist or doctor before adding Giloy, especially given separate liver-injury reports.
- Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
3 of 4Amitriptyline, Chlordiazepoxide also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.
In vitro research shows that Tinospora cordifolia extract inhibits CYP1A2 at high concentrations. However, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist with Limbitrol DS, which combines amitriptyline (an antidepressant) and chlordiazepoxide (a benzodiazepine). The amitriptyline part is partly handled by a liver enzyme called CYP1A2. In lab dish studies, Tinospora cordifolia (Giloy) slowed that enzyme down. If that happened in a person, amitriptyline could build up a bit, which might mean more drowsiness, dry mouth, constipation, blurry vision, dizziness, or grogginess on top of the calming effect the chlordiazepoxide already brings.
I want to be honest though: this is only a test-tube finding at high concentrations, and it has never been reported in real people. So I wouldn't lose sleep over it. Still, since both ingredients can already make you sleepy, please run Giloy by your pharmacist or doctor first.
- Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES
4 of 4Amitriptyline, Chlordiazepoxide also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C9. Animal research shows that Tinospora cordifolia extract 400 mg/kg twice daily for 14 days reduces the clearance and increases plasma levels of glyburide, a CYP2C9 substrate. However, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Limbitrol DS combines amitriptyline (a tricyclic antidepressant) with chlordiazepoxide (a benzodiazepine). One of the liver enzymes that helps break these down is CYP2C9. In test-tube studies, Tinospora cordifolia (Giloy) appears to slow that enzyme down. If that held true in people, your body might clear the medicine a bit more slowly, letting it build up.
With more amitriptyline and chlordiazepoxide around, you could feel extra drowsiness, dizziness, dry mouth, constipation, or grogginess, and some people get a faster heartbeat. I want to be honest though: this is only based on lab and animal research, never confirmed in humans, so it's a theoretical concern rather than a proven problem. Still, please run it past your pharmacist or doctor before combining them.
- Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Tinospora Cordifolia Also Interacts With Other Medications
Tinospora Cordifolia has 611 moderate known drug interactions in our database — the Amitriptyline, Chlordiazepoxide one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Tinospora Cordifolia
We haven’t checked that one against Tinospora Cordifolia yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Tinospora Cordifolia. Pick one to open its full report.
See Every Supplement That Interacts With Amitriptyline, Chlordiazepoxide
This page covers Tinospora Cordifolia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amitriptyline, Chlordiazepoxide page lists 298 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), Arsenic (major) and Beer (major).
By severity: 17 major · 231 moderate · 50 minor.
From our pharmacist’s overview on the Amitriptyline, Chlordiazepoxide page
“Alcohol is the first thing to know about here. Beer and wine both carry major, well-documented interactions with Amitriptyline and Chlordiazepoxide (Limbitrol DS), because both drugs already slow the central nervous system, and anything sedating layered on top can deepen ordinary drowsiness into something dangerous.”
Reviewed by 2 · Jul 18, 2026
Taking Tinospora Cordifolia as Part of a Dietary Supplement Product? Check It for Interactions
We hold 393 real supplement products containing Tinospora Cordifolia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tinospora Cordifolia. Your product may carry other ingredients that interact with Amitriptyline, Chlordiazepoxide too, on top of Tinospora Cordifolia — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Tinospora Cordifolia and Amitriptyline, Chlordiazepoxide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#369 of 1,452 supplements looked up here in the last 7 days
#2,215 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Tinospora Cordifolia
What is Tinospora Cordifolia?
- Immune support
- Fever
- Blood sugar support
- General wellness and 'rejuvenation'
- Allergic rhinitis
- Inflammation
Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Early laboratory and small human studies suggest possible immune and blood sugar effects, but high-quality evidence is limited, and there have been reports of liver injury. Talk with your pharmacist or doctor before using it.
Other Drugs & Tinospora Cordifolia
Browse every other medication we’ve checked against Tinospora Cordifolia — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
611 interactions
- Diclofenac Sodium ›
- Theophylline ›
- Ibuprofen ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Verapamil ›
- Prednisone ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Insulin (pork) ›
- Fentanyl ›
- Flurbiprofen ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Triamcinolone ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Formoterol ›
- Indomethacin ›
- Insulin (human) ›
- Morphine Sulfate ›
- Trimipramine ›
- Acetaminophen ›
- Amphetamine ›
- Diazepam ›
- Lofepramine ›
- Meloxicam ›
- Nortriptyline ›
- Propoxyphene ›
- Acarbose ›
- Aripiprazole ›
- Bendamustine ›
- Betamethasone ›
- Caffeine (otc Drug) ›
- Ciclesonide ›
- Cyclobenzaprine ›
- Desipramine ›
- Doxepin ›
- Duloxetine ›
- Fluphenazine ›
- Insulin Glargine ›
- Omeprazole ›
- Pantoprazole ›
- Paroxetine ›
- Progesterone (prescription Drug) ›
- Riluzole ›
- Semaglutide ›
- Timolol ›
- Tramadol ›
- Vortioxetine ›
- Warfarin Sodium ›
- Amphetamine Sulfate ›
- Aripiprazole Lauroxil ›
Showing 60 of 611 moderate interactions — see all 611 on the Tinospora Cordifolia page.
No interaction 2,218 drugs checked — show the list
We also checked Tinospora Cordifolia against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Abemaciclib ›
- Escitalopram ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Methotrexate ›
- Isotretinoin ›
- Acyclovir ›
- Doxycycline ›
- Amlodipine Besylate ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Gabapentin ›
- Clonazepam ›
- Methylene Blue ›
- Letrozole ›
- Buspirone ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Candesartan Cilexetil ›
- Dapsone ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Cyclopentolate ›
- Cephalexin ›
- Atorvastatin Calcium ›
- Amoxicillin, Clavulanate Potassium ›
- Mannitol ›
- Roxithromycin ›
- Levetiracetam ›
- Ezetimibe ›
- Finasteride ›
- Levothyroxine Sodium ›
- Phentermine, Topiramate ›
- Pegunigalsidase Alfa-iwxj ›
- Dexmethylphenidate ›
- Amlodipine Besylate, Benazepril ›
- Spironolactone ›
- Thyroid Hormone ›
- Daptomycin ›
- Carbidopa, Levodopa ›
- Mitomycin ›
- Acetylsalicylic Acid ›
- Alprazolam ›
Showing the 60 most looked-up of 2,218 medications checked with no known interaction — see the full Tinospora Cordifolia list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Amitriptyline, Chlordiazepoxide Is Linked to Lower Levels of 3 Nutrients
Natural Medicines records Amitriptyline, Chlordiazepoxide as a medicine that can lower these. This is not an interaction with Tinospora Cordifolia — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Amitriptyline, Chlordiazepoxide nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Tinospora Cordifolia and Amitriptyline, Chlordiazepoxide Together: Common Questions
Can you take Tinospora Cordifolia with Amitriptyline, Chlordiazepoxide?
Why are there 4 interactions listed for Tinospora Cordifolia and Amitriptyline, Chlordiazepoxide?
How serious is the Tinospora Cordifolia and Amitriptyline, Chlordiazepoxide interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.