Drug & supplement interaction

Tinospora Cordifolia + Trabectedin

Trabectedin brand name: Yondelis.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Tinospora Cordifolia and Trabectedin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tinospora Cordifolia and Trabectedin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trabectedin and Tinospora Cordifolia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tinospora Cordifolia safety at a glance

Tinospora Cordifol... overall Use caution Generally used in traditional medicine, but reports of liver injury mean it should be used carefully and under guidance.
Pregnancy Avoid Safety has not been established in pregnancy, so it is best avoided.
Breastfeeding Avoid There is not enough reliable safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trabectedin and Tinospora Cordifolia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Trabectedin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Trabectedin is filed under 4 classifications — including alkylating agents, hepatotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Tinospora Cordifolia has documented interactions with 6 drug classes — the most serious being antidiabetes drugs (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and cytochrome p450 2c19 (cyp2c19) substrates (moderate) — and none of Trabectedin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Tinospora Cordifolia Does Interact With Other Medications

Tinospora Cordifolia has 612 moderate known drug interactions in our database — Trabectedin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 612 No known interaction 2,218 (incl. Trabectedin)
Taking anything else?

Check Another of Your Medications Against Tinospora Cordifolia

Covers the 2,830 medications we’ve checked against Tinospora Cordifolia. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Tinospora Cordifolia and Trabectedin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Tinospora Cordifolia

    “Orally, liver injury is reported after consumption of Tinospora cordifolia. In 2 case series, autoimmune hepatitis, acute hepatitis, worsening of chronic liver disease, or acute liver failure is reported in 49 patients after consuming various forms and doses of Tinospora cordifolia alone or in combination with other ingredients for a median of 42-90 days.”

    Tinospora Cordifolia · Natural Medicines adverse-effect record, reported in cirrhosis.

    4 sources cited
    1. 110533. Kulkarni AV, Hanchanale P, Prakash V, et al. Tinospora Cordifolia (Giloy)-Induced Liver Injury During the COVID-19 Pandemic-Multicenter Nationwide Study From India. Hepatol Commun 2022;6(6):1289-1300. PubMed
    2. 110534. Nagral A, Adhyaru K, Rudra OS, Gharat A, Bhandare S. Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series. J Clin Exp Hepatol. 2021;11(6):732-738. PubMed
    3. 112404. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed
    4. 112405. May K, Jeitler M, Murthy V, Stapelfeldt E, Kessler CS. A Case Report of Acute Hepatitis Involving the Medicinal Herb Tinospora cordifolia Along with Other Variables. J Integr Complement Med 2023;29(5):327-333.

    Trabectedin

    Listed in the ADVERSE REACTIONS section of the FDA label for Trabectedin. Read the label on DailyMed ›

  • Reduced appetite / Nausea / Tiredness reported in 8.8% of FDA reports for Trabectedin Additional detail

    Tinospora Cordifolia

    Recorded for Tinospora Cordifolia in the same Natural Medicines adverse-effect record shown under Liver problems above.

    Trabectedin

    Listed in the ADVERSE REACTIONS section of the FDA label for Trabectedin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Headache Additional detail

    Tinospora Cordifolia

    “Orally, Tinospora cordifolia has been reported to cause headache in a clinical trial.”

    Tinospora Cordifolia · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 15085. Badar VA, Thawani VR, Wakode PT, et al. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol 2005;96:445-9. PubMed

    Trabectedin

    Listed in the ADVERSE REACTIONS section of the FDA label for Trabectedin. Read the label on DailyMed ›

Reported for Tinospora Cordifolia but not commonly for Trabectedin: stomach pain and itching.

Effects for Trabectedin come from the ADVERSE REACTIONS section of its FDA label; effects for Tinospora Cordifolia come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 2,260 voluntary FDA FAERS reports for Trabectedin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Trabectedin Is Prescribed For, and What Tinospora Cordifolia Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Trabectedin is a prescription medicine with approved uses on its FDA label. Tinospora Cordifolia is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Trabectedin is prescribed for: Yondelis (trabectedin injection) is used to treat adults with liposarcoma or leiomyosarcoma — two types of soft tissue sarcoma (cancer of connective tissue) — when the cancer cannot be removed by surgery (unresectable) or has spread to other parts of the body (metastatic). It is indicated for patients who have already received a prior treatment regimen containing an anthracycline (a type of chemotherapy).

Tinospora Cordifolia has been studied for:

  • Cancer studied, not established Tinospora Cordifolia has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Tinospora Cordifolia for cancer

    Although there has been interest in using oral Tinospora cordifolia for cancer, there is insufficient reliable information about the clinical effects of Tinospora cordifolia for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Trabectedin on your own; if you are taking Tinospora Cordifolia for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Trabectedin

This page covers Tinospora Cordifolia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trabectedin page lists 156 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Grapefruit (major), Siberian Cocklebur (major), St. John's Wort (major) and Wine (major).

By severity: 5 major · 122 moderate · 29 minor.

From our pharmacist’s overview on the Trabectedin page

“People receiving trabectedin (Yondelis), an infused chemotherapy for soft tissue sarcoma and some ovarian cancers, often reach for supplements to boost energy or support a stressed liver, and that instinct is exactly where the trouble sits. This list warrants real caution.”

Reviewed by 2 · Jul 18, 2026

Open the Trabectedin interaction page

One more smart check

Taking Tinospora Cordifolia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 393 real supplement products containing Tinospora Cordifolia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tinospora Cordifolia. Even though Tinospora Cordifolia itself has no known interaction with Trabectedin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tinospora Cordifolia and Trabectedin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tinospora Cordifolia
Top 25%

#353 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trabectedin
Top 25%

#614 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tinospora Cordifolia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Tinospora Cordifolia and Trabectedin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tinospora Cordifolia

What is Tinospora Cordifolia?

  • Immune support
  • Fever
  • Blood sugar support
  • General wellness and 'rejuvenation'
  • Allergic rhinitis
  • Inflammation

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Early laboratory and small human studies suggest possible immune and blood sugar effects, but high-quality evidence is limited, and there have been reports of liver injury. Talk with your pharmacist or doctor before using it.

Tinospora cordifolia · Menispermaceae · Stem (mainly), root, and leaves · Capsules, tablets, powder (churna), liquid extract, juice, and decoctions

An interaction check asks whether these two react with each other — it does not ask whether Tinospora Cordifolia is a good idea for someone in your situation. Here is what our Tinospora Cordifolia record says about it on its own.

Tinospora Cordifolia: dosing

There is no well-established standardized dose for Tinospora cordifolia. Do not exceed the label dose, and avoid long-term use without medical supervision.

From our Tinospora Cordifolia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tinospora Cordifolia monograph & all interactions
Medication

About Trabectedin Injection

What Is Trabectedin Injection Used For?

Brand name: Yondelis

Yondelis (trabectedin injection) is used to treat adults with liposarcoma or leiomyosarcoma — two types of soft tissue sarcoma (cancer of connective tissue) — when the cancer cannot be removed by surgery (unresectable) or has spread to other parts of the body (metastatic). It is indicated for patients who have already received a prior treatment regimen containing an anthracycline (a type of chemotherapy).

See full Trabectedin Injection drug information
Keep checking

Other Drugs & Tinospora Cordifolia

Browse every other medication we’ve checked against Tinospora Cordifolia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
612Moderate
0Minor
2,217No known interaction
612 Moderate 2,217 No interaction
Moderate

612 interactions

Showing 60 of 612 moderate interactions — see all 612 on the Tinospora Cordifolia page.

No interaction 2,217 drugs checked — show the list

We also checked Tinospora Cordifolia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,217 medications checked with no known interaction — see the full Tinospora Cordifolia list.

See the full Tinospora Cordifolia interactions page
See every supplement checked against Trabectedin, ranked by severity
Evidence & sources

Tinospora Cordifolia References

The 16 references that drive our Tinospora Cordifolia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Stanely Mainzen Prince P, Menon VP. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother Res 2003;17:410-3.
  2. Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000;73:461-70. PubMed
  3. Manjrekar PN, Jolly CI, Narayanan S. Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 2000;71:254-7. PubMed
  4. Prince PS, Menon VP. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J Ethnopharmacol 1999;65:277-81. PubMed
  5. Stanely Mainzen Prince P, Menon VP, Gunasekaran G. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J Ethnopharmacol 1999;64:53-7. PubMed
  6. Badar VA, Thawani VR, Wakode PT, et al. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol 2005;96:445-9. PubMed
  7. Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997;58:89-95. PubMed
  8. Nair PK, Rodriguez S, Ramachandran R, et al. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int Immunopharmacol 2004;4:1645-59. PubMed
  9. Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF. Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial. J Pharmacol Pharmacother. 2 PubMed
  10. Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
  11. Patial V, Katoch S, Chhimwal J, Singh PP, Suresh PS, Padwad Y. Tinospora cordifolia activates PPAR? pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease. Phytomedicine 2021;91:153663. PubMed
  12. Kulkarni AV, Hanchanale P, Prakash V, et al. Tinospora Cordifolia (Giloy)-Induced Liver Injury During the COVID-19 Pandemic-Multicenter Nationwide Study From India. Hepatol Commun 2022;6(6):1289-1300. PubMed
  13. Nagral A, Adhyaru K, Rudra OS, Gharat A, Bhandare S. Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series. J Clin Exp Hepatol. 2021;11(6):732-738. PubMed
  14. Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
  15. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tinospora Cordifolia and Trabectedin Together: Common Questions

Is it safe to take Tinospora Cordifolia with Trabectedin?
We do not list a known interaction between Tinospora Cordifolia and Trabectedin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tinospora Cordifolia and Trabectedin have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Tinospora Cordifolia and Trabectedin used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Tinospora Cordifolia in each. That is a conversation for your prescriber, especially if Trabectedin is being adjusted to a target.
How was the Tinospora Cordifolia and Trabectedin combination checked?
Interactions in our licensed database are recorded against drug classes. Trabectedin is filed under 4 classifications, and Tinospora Cordifolia has documented interactions with 6 drug classes — none of Trabectedin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Tinospora Cordifolia interact with any other medications?
Yes. Tinospora Cordifolia has 612 documented drug interactions in our database — Trabectedin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Trabectedin interact with any supplements?
Yes. Trabectedin has documented interactions with 156 supplements in our database — Tinospora Cordifolia is not one of them. The Trabectedin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tinospora Cordifolia monograph Uses, safety profile, and every drug interaction in one place Trabectedin Injection drug information The full plain-English guide to this medication Trabectedin supplement interactions Every supplement checked against Trabectedin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 16 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.