Drug & supplement interaction

White Mulberry + Roflumilast

Roflumilast brand names: Daliresp, Zoryve.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between White Mulberry and Roflumilast in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

White Mulberry and Roflumilast

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Roflumilast and White Mulberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

White Mulberry safety at a glance

White Mulberry overall Use caution Likely safe as a food, but concentrated supplements are less studied and may lower blood sugar.
Pregnancy Avoid Not enough safety data; avoid medicinal amounts during pregnancy.
Breastfeeding Avoid Not enough safety data; avoid medicinal amounts while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis

White mulberry is not known to have many clinically significant drug interactions.

While our drug-herb interaction checker does list potential interactions with antidiabetic drugs and drugs that are affected by a protein known as OCT2, it is generally thought these are clinically insignificant for most individuals as they are theoretical and have not been seen in humans.

Nevertheless, it is important to be cautious if you take any drug that our tool shows an interaction for.

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Still wondering about combining Roflumilast and White Mulberry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Roflumilast

Interactions in our licensed database are recorded against drug classes, not just single drug names. Roflumilast is filed under 3 classifications — topical drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. White Mulberry has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and organic cation transporter 2 (oct2) substrates (moderate) — and none of Roflumilast’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

White Mulberry Does Interact With Other Medications

White Mulberry has 87 moderate known drug interactions in our database — Roflumilast isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Roflumilast)
Taking anything else?

Check Another of Your Medications Against White Mulberry

Covers the 2,830 medications we’ve checked against White Mulberry. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests White Mulberry and Roflumilast May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea Additional detail

    White Mulberry

    “Orally, white mulberry leaf powder 4.6 grams three times daily for 4 weeks was associated with bloating and flatulence in 50% of patients, loose stools in 25% of patients, and constipation in 21% of patients in one clinical study. However, reports of these adverse effects decreased over the course of the 12-week study, suggesting that for some patients the adverse effects may be transient in nature.”

    White Mulberry · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 103870. Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. PubMed

    Roflumilast

    Listed in the ADVERSE REACTIONS section of the FDA label for Roflumilast. Read the label on DailyMed ›

Reported for White Mulberry but not commonly for Roflumilast: constipation and bloating or gas.

Effects for Roflumilast come from the ADVERSE REACTIONS section of its FDA label; effects for White Mulberry come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About White Mulberry or Roflumilast

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers White Mulberry or Roflumilast, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Roflumilast

This page covers White Mulberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Roflumilast page lists 141 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 96 moderate · 42 minor.

From our pharmacist’s overview on the Roflumilast page

“Roflumilast (Daliresp for severe COPD, Zoryve as a cream for skin conditions) is cleared almost entirely by one liver enzyme, CYP3A4, which is why 121 of the 141 supplements on this page can push its level up or down, and why real caution is warranted here. Start with the three rated major: grapefruit blocks that enzyme and can raise r…”

Reviewed by 2 · Jul 18, 2026

Open the Roflumilast interaction page

One more smart check

Taking White Mulberry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 282 real supplement products containing White Mulberry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides White Mulberry. Even though White Mulberry itself has no known interaction with Roflumilast, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where White Mulberry and Roflumilast Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement White Mulberry
Top half

#456 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Roflumilast
Top half

#944 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every White Mulberry reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The White Mulberry and Roflumilast records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About White Mulberry

What is White Mulberry?

White Mulberry
  • Blood sugar support
  • High cholesterol
  • Weight management
  • Antioxidant support
  • High blood pressure (traditional use)

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is generally well tolerated as a food and tea, but talk to your pharmacist or doctor before using concentrated supplements, especially if you take diabetes medicine.

Morus alba · Moraceae · Leaves, fruit (berries), root bark, and twigs · Capsules, tablets, leaf tea, powdered leaf extract, dried fruit, liquid extracts

An interaction check asks whether these two react with each other — it does not ask whether White Mulberry is a good idea for someone in your situation. Here is what our White Mulberry record says about it on its own.

White Mulberry: dosing

There is no officially established standard dose for white mulberry supplements. Doses used in studies have varied widely depending on the plant part and extract, and there is not enough consistent research to recommend a specific milligram amount.If you choose to use it, follow the directions on the product label and do not exceed the suggested amount.

From our White Mulberry monograph — the full record covers uses, side effects and every documented interaction.

Read the full White Mulberry monograph & all interactions
Medication

About Roflumilast

What Is Roflumilast Used For?

Brand names: Daliresp, Zoryve

Daliresp and roflumilast tablets are used to reduce the risk of COPD (chronic obstructive pulmonary disease) flare-ups in adults with severe COPD linked to chronic bronchitis who have had flare-ups in the past. They are not rescue inhalers and will not relieve a sudden breathing attack.

Zoryve cream is used topically to treat plaque psoriasis (adults and children 2+) and mild to moderate atopic dermatitis (eczema) in adults and children as young as 2. Zoryve topical foam is used to treat seborrheic dermatitis (adults and children 9+) and plaque psoriasis of the scalp and body (adults and children 12+).

Most-Reported Side Effects for Roflumilast

From FAERS, the FDA’s public side-effect reporting system (6,927 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 1,054 reports
Chronic obstructive pulmonary disease 657 reports
Diarrhea 596 reports
Nausea 491 reports
Pneumonia 476 reports
See full Roflumilast drug information
Keep checking

Other Drugs & White Mulberry

Browse every other medication we’ve checked against White Mulberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
87Moderate
0Minor
2,742No known interaction
87 Moderate 2,742 No interaction
Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the White Mulberry page.

No interaction 2,742 drugs checked — show the list

We also checked White Mulberry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full White Mulberry list.

See the full White Mulberry interactions page
See every supplement checked against Roflumilast, ranked by severity
Evidence & sources

White Mulberry References

The 6 references that drive our White Mulberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. PubMed
  2. Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. PubMed
  3. Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. PubMed
  4. Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49. PubMed
  5. Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. PubMed
  6. Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking White Mulberry and Roflumilast Together: Common Questions

Is it safe to take White Mulberry with Roflumilast?
We do not list a known interaction between White Mulberry and Roflumilast. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do White Mulberry and Roflumilast have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the White Mulberry and Roflumilast combination checked?
Interactions in our licensed database are recorded against drug classes. Roflumilast is filed under 3 classifications, and White Mulberry has documented interactions with 2 drug classes — none of Roflumilast's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does White Mulberry interact with any other medications?
Yes. White Mulberry has 87 documented drug interactions in our database — Roflumilast is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Roflumilast interact with any supplements?
Yes. Roflumilast has documented interactions with 141 supplements in our database — White Mulberry is not one of them. The Roflumilast interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

White Mulberry monograph Uses, safety profile, and every drug interaction in one place Roflumilast drug information The full plain-English guide to this medication Roflumilast supplement interactions Every supplement checked against Roflumilast, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Roflumilast and White Mulberry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.