Medication interaction hub

What Supplements Interact with Aspirin, Butalbital?

Aspirin, Butalbital brand name: Axotal. Every interaction below applies to the brands too.

245 Interactions 7 Major 208 Moderate 30 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Aspirin, Butalbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Aspirin, Butalbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

245 supplements and herbal ingredients have interactions with Aspirin, Butalbital on file in the HelloPharmacist interaction database — 7 rated major, 208 moderate, and 30 minor. The most serious involve Siberian Cocklebur, Activated Charcoal, Beer, Danshen and Piracetam.

Our assessment: with 7 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Aspirin, Butalbital.

Major 7 Moderate 208 Minor 30 No known interaction 1,207

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Aspirin, Butalbital: Top Interactions at a Glance

The Aspirin, Butalbital supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 245 interacting ingredients — plus 1,207 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Aspirin, Butalbital Combinations Today

The Aspirin, Butalbital + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Alpha-lipoic Acid + Aspirin, Butalbitali

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Niacin + Aspirin, Butalbitali

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Unlikely Acerola + Aspirin, Butalbitali

Theoretically, acerola might reduce the clearance of aspirin; however, its vitamin C content is likely too low to produce clinically significant effects.

Read the full interaction Minor Likelihood Unlikely Fish Oil + Aspirin, Butalbitali

Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Bromelain + Aspirin, Butalbitali

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Possible Chromium + Aspirin, Butalbitali

NSAIDs might increase chromium levels in the body.

Read the full interaction
The complete list

Every Supplement Checked Against Aspirin, Butalbital

All 1,452 ingredients in our database, ranked by severity — 245 with a Aspirin, Butalbital interaction on file and 1,207 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Aspirin, Butalbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Alpha-lipoic Acid with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplate...

Full Alpha-lipoic Acid + Aspirin, Butalbital answer

Can you take Niacin with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Full Niacin + Aspirin, Butalbital answer

Can you take Acerola with Aspirin, Butalbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, acerola might reduce the clearance of aspirin; however, its vitamin C content is likely too low to produce clinically signifi...

Full Acerola + Aspirin, Butalbital answer

Can you take Fish Oil with Aspirin, Butalbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Fish Oil + Aspirin, Butalbital answer

Can you take Bromelain with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Bromelain + Aspirin, Butalbital answer

Can you take Japanese Persimmon with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is concern that Japanese persimmon leaf constituents might potentiate effects of anticoagulant and antiplatelet drugs.

Full Japanese Persimmon + Aspirin, Butalbital answer

Can you take Jequirity with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that constituents of jequirity beans can inhibit platelet aggregation.

Full Jequirity + Aspirin, Butalbital answer

Can you take Jiaogulan with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Jiaogulan + Aspirin, Butalbital answer

Can you take Kinetin with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that kinetin inhibits human platelet aggregation and activation.

Full Kinetin + Aspirin, Butalbital answer

Can you take Kiwi with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research suggests that kiwi inhibits platelet aggregation.

Full Kiwi + Aspirin, Butalbital answer

Can you take Krill Oil with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Krill Oil + Aspirin, Butalbital answer

Can you take Kudzu with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.

Full Kudzu + Aspirin, Butalbital answer

Can you take L-arginine with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of...

Full L-arginine + Aspirin, Butalbital answer

Can you take Lion's Mane Mushroom with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Full Lion's Mane Mushroom + Aspirin, Butalbital answer

Can you take Lotus with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of lotus with other antiplatelet drugs might reduce platelet aggregation and increase the risk of bleeding.

Full Lotus + Aspirin, Butalbital answer

Can you take Lycopene with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Full Lycopene + Aspirin, Butalbital answer

Can you take Magnolia with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Full Magnolia + Aspirin, Butalbital answer

Can you take Mangosteen with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.

Full Mangosteen + Aspirin, Butalbital answer

Can you take Maral Root with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that maral root tincture can reduce platelet aggregation.

Full Maral Root + Aspirin, Butalbital answer

Can you take Maritime Pine with Aspirin, Butalbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Full Maritime Pine + Aspirin, Butalbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Aspirin, Butalbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Aspirin, Butalbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Aspirin, Butalbital sits in 8 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Aspirin, Butalbital through this category.

Aspirin 22 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

22 of the supplement ingredients on this page reach Aspirin, Butalbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Butalbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Butalbital through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Butalbital through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Butalbital through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Butalbital through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Butalbital through this category.

Related: does Aspirin, Butalbital deplete any nutrients?

Aspirin, Butalbital has 4 reported nutrient associations in the research literature — see the Aspirin, Butalbital nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Aspirin, Butalbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Aspirin, Butalbital.

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Pharmacist Counseling Corner

Aspirin, Butalbital & Supplements: Common Questions

What supplements interact with Aspirin, Butalbital?
Our database currently documents 245 ingredients with a known Aspirin, Butalbital interaction (7 major, 208 moderate, 30 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 245. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Aspirin, Butalbital supplement interactions are the most serious?
The 7 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer, Danshen and Piracetam — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Aspirin, Butalbital?
Plenty of supplements coexist fine with Aspirin, Butalbital; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Axotal have the same supplement interactions as Aspirin, Butalbital?
Yes — Axotal all contain Aspirin, Butalbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Aspirin, Butalbital deplete any vitamins or nutrients?
It might — Aspirin, Butalbital has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Aspirin, Butalbital nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Aspirin, Butalbital and my other medications?
This page covers Aspirin, Butalbital against supplements and herbal ingredients. Checking Aspirin, Butalbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.