Medication interaction hub

What Supplements Interact with Famotidine, Ibuprofen?

Famotidine, Ibuprofen brand name: Duexis. Every interaction below applies to the brands too.

297 Interactions 7 Major 245 Moderate 45 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Famotidine, Ibuprofen? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Famotidine, Ibuprofen against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

297 supplements and herbal ingredients have interactions with Famotidine, Ibuprofen on file in the HelloPharmacist interaction database — 7 rated major, 245 moderate, and 45 minor. The most serious involve Siberian Cocklebur, Activated Charcoal, Beer, Danshen and Piracetam.

Our assessment: with 7 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Famotidine, Ibuprofen.

Major 7 Moderate 245 Minor 45 No known interaction 1,155

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Famotidine, Ibuprofen: Top Interactions at a Glance

The Famotidine, Ibuprofen supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 297 interacting ingredients — plus 1,155 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Famotidine, Ibuprofen Combinations Today

The Famotidine, Ibuprofen + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Betaine Hydrochloride + Famotidine, Ibuprofeni

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.

Read the full interaction Minor Likelihood Possible Quassia + Famotidine, Ibuprofeni

Theoretically, due to reports that quassia increases stomach acid, quassia might decrease the effectiveness of H2-blockers.

Read the full interaction Minor Likelihood Possible Blessed Thistle + Famotidine, Ibuprofeni

Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.

Read the full interaction Moderate Likelihood Probable Willow Bark + Famotidine, Ibuprofeni

Theoretically, willow bark might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Vitamin E + Famotidine, Ibuprofeni

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.

Read the full interaction Moderate Likelihood Possible Rue + Famotidine, Ibuprofeni

Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Famotidine, Ibuprofen

All 1,452 ingredients in our database, ranked by severity — 297 with a Famotidine, Ibuprofen interaction on file and 1,155 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Famotidine, Ibuprofen?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Betaine Hydrochloride with Famotidine, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.

Full Betaine Hydrochloride + Famotidine, Ibuprofen answer

Can you take Quassia with Famotidine, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, due to reports that quassia increases stomach acid, quassia might decrease the effectiveness of H2-blockers.

Full Quassia + Famotidine, Ibuprofen answer

Can you take Blessed Thistle with Famotidine, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.

Full Blessed Thistle + Famotidine, Ibuprofen answer

Can you take Willow Bark with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, willow bark might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Full Willow Bark + Famotidine, Ibuprofen answer

Can you take Vitamin E with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.

Full Vitamin E + Famotidine, Ibuprofen answer

Can you take Maritime Pine with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Full Maritime Pine + Famotidine, Ibuprofen answer

Can you take Marjoram with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that marjoram extract inhibits platelet aggregation and adhesion.

Full Marjoram + Famotidine, Ibuprofen answer

Can you take Melatonin with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Famotidine, Ibuprofen answer

Can you take Mesoglycan with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combined use might increase bleeding risk.

Full Mesoglycan + Famotidine, Ibuprofen answer

Can you take Methoxylated Flavones with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that some methoxylated flavones have antiplatelet effects.

Full Methoxylated Flavones + Famotidine, Ibuprofen answer

Can you take Mountain Ash with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.

Full Mountain Ash + Famotidine, Ibuprofen answer

Can you take N-acetyl Cysteine (nac) with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full N-acetyl Cysteine (nac) + Famotidine, Ibuprofen answer

Can you take Nattokinase with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Full Nattokinase + Famotidine, Ibuprofen answer

Can you take Neem with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C9 substrates.

Full Neem + Famotidine, Ibuprofen answer

Can you take Niacin with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Full Niacin + Famotidine, Ibuprofen answer

Can you take Octacosanol with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically si...

Full Octacosanol + Famotidine, Ibuprofen answer

Can you take Onion with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of anticoagulant or antiplatelet drugs with onion might increase the risk of bleeding.

Full Onion + Famotidine, Ibuprofen answer

Can you take Oolong Tea with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oolong tea might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Oolong Tea + Famotidine, Ibuprofen answer

Can you take Oregano with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Oregano + Famotidine, Ibuprofen answer

Can you take Oregon Grape with Famotidine, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2C9.

Full Oregon Grape + Famotidine, Ibuprofen answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Famotidine, Ibuprofen is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Famotidine, Ibuprofen, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Famotidine, Ibuprofen sits in 11 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Famotidine, Ibuprofen through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Famotidine, Ibuprofen through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Famotidine, Ibuprofen through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Famotidine, Ibuprofen through this category.

H2-Blockers 14 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

14 of the supplement ingredients on this page reach Famotidine, Ibuprofen through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Famotidine, Ibuprofen through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Famotidine, Ibuprofen through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Famotidine, Ibuprofen through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Famotidine, Ibuprofen through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Famotidine, Ibuprofen through this category.

Ibuprofen (Advil, Others) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Famotidine, Ibuprofen through this category.

Related: does Famotidine, Ibuprofen deplete any nutrients?

Famotidine, Ibuprofen has 6 reported nutrient associations in the research literature — see the Famotidine, Ibuprofen nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Famotidine, Ibuprofen

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Famotidine, Ibuprofen.

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Pharmacist Counseling Corner

Famotidine, Ibuprofen & Supplements: Common Questions

What supplements interact with Famotidine, Ibuprofen?
More than you might expect — 297 in total, though they are far from equal: 7 are rated major, 245 moderate, and 45 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Famotidine, Ibuprofen supplement interactions are the most serious?
The 7 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer, Danshen and Piracetam — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Famotidine, Ibuprofen?
Usually yes — most people on Famotidine, Ibuprofen can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Duexis have the same supplement interactions as Famotidine, Ibuprofen?
Yes — Duexis all contain Famotidine, Ibuprofen, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Famotidine, Ibuprofen deplete any vitamins or nutrients?
It might — Famotidine, Ibuprofen has 6 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Famotidine, Ibuprofen nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Famotidine, Ibuprofen and my other medications?
This page covers Famotidine, Ibuprofen against supplements and herbal ingredients. Checking Famotidine, Ibuprofen against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.