Medication interaction hub

What Supplements Interact with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Guaifenesin, Phenylephrine, Phenylpropanolamine brand names: Dura Gest, Entex. Every interaction below applies to the brands too.

62 Interactions 5 Major 44 Moderate 13 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Guaifenesin, Phenylephrine, Phenylpropanolamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Guaifenesin, Phenylephrine, Phenylpropanolamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Entex (guaifenesin, phenylephrine, phenylpropanolamine) treats congestion with two decongestants that behave like mild stimulants, squeezing blood vessels and pushing blood pressure up. That built-in stimulant effect is why its list of 62 supplement interactions deserves genuine care, and why five entries rate major. Most of the list stacks stimulant on stimulant; ephedra leads the major risks, and caffeine in almost any form accounts for a large share of the 44 moderate entries by adding jitters, a faster heartbeat, and higher blood pressure.

A smaller group of 17 works the other way, cutting how much of any oral medicine you absorb. Activated charcoal is the standout there, the one major that is not a stimulant issue, so keep it well separated from your dose. The other 13 entries rate minor. Start with the five major listings below and read those closely, because that is where the serious risk sits.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 44 Minor 13 No known interaction 1,390

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Guaifenesin, Phenylephrine, Phenylpropanolamine: Top Interactions at a Glance

The most significant Guaifenesin, Phenylephrine, Phenylpropanolamine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 62 interacting ingredients — plus 1,390 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Guaifenesin, Phenylephrine, Phenylpropanolamine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Guaifenesin, Phenylephrine, Phenylpropanolaminei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Ephedra + Guaifenesin, Phenylephrine, Phenylpropanolaminei

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction Major Likelihood Probable Peyote + Guaifenesin, Phenylephrine, Phenylpropanolaminei

Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Read the full interaction Major Likelihood Probable Rauvolfia Vomitoria + Guaifenesin, Phenylephrine, Phenylpropanolaminei

Theoretically, concomitant use might cause additive effects.

Read the full interaction Major Likelihood Probable Sida Cordifolia + Guaifenesin, Phenylephrine, Phenylpropanolaminei

Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Guaifenesin, Phenylephrine, Phenylpropanolamine

All 1,452 ingredients in our database, ranked by severity — 62 with a Guaifenesin, Phenylephrine, Phenylpropanolamine interaction on file and 1,390 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Guaifenesin, Phenylephrine, Phenylpropanolamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Butcher's Broom with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.

Full Butcher's Broom + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Dimethylhexylamine (dmha) with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining DMHA with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Dimethylhexylamine (dmha) + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Ergot with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Co-administration of stimulant drugs with ergot may increase the risk of vasoconstriction.

Full Ergot + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Guar Gum with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Gum Arabic with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Higenamine with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the risk of cardiovascular toxicity when taken with stimulant drugs.

Full Higenamine + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Hordenine with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hordenine is structurally similar to N-methyltyramine and synephrine, constituents in bitter orange known to have stimulant properties.

Full Hordenine + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Indian Snakeroot with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive effects.

Full Indian Snakeroot + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Isopropylnorsynephrine with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking isopropylnorsynephrine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascula...

Full Isopropylnorsynephrine + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Khat with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cathinone, a constituent of khat, appears to have sympathomimetic effects and can increase blood pressure and heart rate.

Full Khat + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Methylsynephrine with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Methylsynephrine has cardiac stimulant effects.

Full Methylsynephrine + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Panax Ginseng with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax ginseng with stimulant drugs might increase the risk of adverse stimulant effects.

Full Panax Ginseng + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Phenpromethamine with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effe...

Full Phenpromethamine + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Raspberry Ketone with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.

Full Raspberry Ketone + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Rauwolscine with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.

Full Rauwolscine + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Securinega Suffruticosa with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.

Full Securinega Suffruticosa + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Slippery Elm with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Tragacanth with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Yohimbe with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking yohimbe with stimulant drugs can have additive effects.

Full Yohimbe + Guaifenesin, Phenylephrine, Phenylpropanolamine answer

Can you take Thyroid Extract with Guaifenesin, Phenylephrine, Phenylpropanolamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Guaifenesin, Phenylephrine, Phenylpropanolamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Guaifenesin, Phenylephrine, Phenylpropanolamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Guaifenesin, Phenylephrine, Phenylpropanolamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Guaifenesin, Phenylephrine, Phenylpropanolamine sits in 4 interaction categories. Open any one to see what the group means:

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Guaifenesin, Phenylephrine, Phenylpropanolamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Guaifenesin, Phenylephrine, Phenylpropanolamine through this category.

Phenylpropanolamine 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Guaifenesin, Phenylephrine, Phenylpropanolamine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Guaifenesin, Phenylephrine, Phenylpropanolamine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Guaifenesin, Phenylephrine, Phenylpropanolamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Guaifenesin, Phenylephrine, Phenylpropanolamine.

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Pharmacist Counseling Corner

Guaifenesin, Phenylephrine, Phenylpropanolamine & Supplements: Common Questions

What supplements interact with Guaifenesin, Phenylephrine, Phenylpropanolamine?
More than you might expect — 62 in total, though they are far from equal: 5 are rated major, 44 moderate, and 13 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Ephedra, Peyote.
Which Guaifenesin, Phenylephrine, Phenylpropanolamine supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Ephedra, Peyote, Rauvolfia Vomitoria and Sida Cordifolia. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Guaifenesin, Phenylephrine, Phenylpropanolamine?
Usually yes — most people on Guaifenesin, Phenylephrine, Phenylpropanolamine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Dura Gest have the same supplement interactions as Guaifenesin, Phenylephrine, Phenylpropanolamine?
Yes — Dura Gest, Entex all contain Guaifenesin, Phenylephrine, Phenylpropanolamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Guaifenesin, Phenylephrine, Phenylpropanolamine and my other medications?
This page covers Guaifenesin, Phenylephrine, Phenylpropanolamine against supplements and herbal ingredients. Checking Guaifenesin, Phenylephrine, Phenylpropanolamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.