Drug & supplement interaction

Pu-erh Tea + Guaifenesin, Phenylephrine, Phenylpropanolamine

Guaifenesin, Phenylephrine, Phenylpropanolamine brand names: Dura Gest, Entex.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Guaifenesin, Phenylephrine, Phenylpropanolamine falls into 2 drug categories that Pu-erh Tea can interact with; the most serious is rated moderate. Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction report
SeverityModerate
LikelihoodProbable
Interactions2
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Pu-erh Tea and Guaifenesin, Phenylephrine, Phenylpropanolamine

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Pu-erh Tea interacts with whole categories of medication. Guaifenesin, Phenylephrine, Phenylpropanolamine falls into 2 of those categories, so it can interact with Pu-erh Tea in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

STIMULANT DRUGS

1 of 2

Why this applies to Guaifenesin, Phenylephrine, Phenylpropanolamine

Guaifenesin, Phenylephrine, Phenylpropanolamine falls under STIMULANT DRUGS — the group Pu-erh Tea interacts with.

Theoretically, concomitant use might increase stimulant adverse effects.
Pu-erh tea contains caffeine. Due to the central nervous system (CNS) stimulant effects of caffeine, concomitant use with stimulant drugs can increase the risk of adverse effects.
Severity Moderate Likelihood Probable Evidence C

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

The thing to keep in mind here is the phenylephrine and phenylpropanolamine part of this combination product. Those are decongestants that gently rev up your system, and pu-erh tea brings its own kick from caffeine. Stack the two together and you may feel more of that stimulant buzz: a faster or pounding heartbeat, jitteriness, trouble sleeping, restlessness, or a bump in blood pressure. The guaifenesin piece (the mucus thinner) doesn't really play into this.

This is more of a theoretical, common-sense caution than a proven danger, and an occasional cup with these meds is unlikely to cause real trouble for most folks. But if you tend to get wired from caffeine, have high blood pressure, or notice your heart racing, it's worth checking with your pharmacist or doctor before pairing them regularly.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html. DOI
Moderate

PHENYLPROPANOLAMINE

2 of 2

Guaifenesin, Phenylephrine, Phenylpropanolamine also falls under PHENYLPROPANOLAMINE.

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Pu-erh tea contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.
Severity Moderate Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination product contains phenylpropanolamine, a decongestant that already nudges your blood pressure up and can leave you feeling jittery or wired. Pu-erh tea brings caffeine to the table, and the two can add together in two ways: a bigger bump in blood pressure, and higher caffeine levels in your blood because phenylpropanolamine appears to slow how your body clears caffeine.

In real life that might show up as a racing heart, restlessness, trouble sleeping, headache, or feeling shaky. The guaifenesin and phenylephrine pieces aren't the main concern here. A single cup probably won't cause trouble for most people, but stacking several cups (or other caffeine sources) is where I'd be cautious. If you have high blood pressure or heart issues, please check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brown NJ, Ryder D, Branch RA. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clin Pharmacol Ther 1991;50:363-71. PubMed
  2. Lake CR, Rosenberg DB, Gallant S, et al. Phenylpropanolamine increases plasma caffeine levels. Clin Pharmacol Ther 1990;47:675-85. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Pu-erh Tea Also Interacts With Other Medications

Pu-erh Tea has 9 major, 447 moderate, 210 minor known drug interactions in our database — the Guaifenesin, Phenylephrine, Phenylpropanolamine one above is among them. If you take anything else, check it against the full list below.

Major 9 Moderate 447 Minor 210 No known interaction 2,164 (incl. Guaifenesin, Phenylephrine, Phenylpropanolamine)
Taking anything else?

Check Another of Your Medications Against Pu-erh Tea

Covers the 2,830 medications we’ve checked against Pu-erh Tea. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Guaifenesin, Phenylephrine, Phenylpropanolamine

This page covers Pu-erh Tea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Guaifenesin, Phenylephrine, Phenylpropanolamine page lists 62 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Peyote (major), Rauvolfia Vomitoria (major) and Sida Cordifolia (major).

By severity: 5 major · 44 moderate · 13 minor.

From our pharmacist’s overview on the Guaifenesin, Phenylephrine, Phenylpropanolamine page

“Entex (guaifenesin, phenylephrine, phenylpropanolamine) treats congestion with two decongestants that behave like mild stimulants, squeezing blood vessels and pushing blood pressure up. That built-in stimulant effect is why its list of 62 supplement interactions deserves genuine care, and why five entries rate major.”

Reviewed by 2 · Jul 18, 2026

Open the Guaifenesin, Phenylephrine, Phenylpropanolamine interaction page

How much people look this up

Where Pu-erh Tea and Guaifenesin, Phenylephrine, Phenylpropanolamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pu-erh Tea
Steady interest

#900 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Guaifenesin, Phenylephrine, Phenylpropanolamine
Top 25%

#327 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Pu-erh Tea

What is Pu-erh Tea?

  • Weight management
  • Cholesterol and heart health
  • Digestion after meals
  • Mental alertness
  • General antioxidant support

Pu-erh tea is a fermented, aged form of tea made from the same plant as green and black tea. It is enjoyed worldwide as a beverage and is sometimes promoted for weight loss, cholesterol, and digestion, but human evidence for these uses is limited. As a normal drink it is generally well tolerated, though it does contain caffeine.

Read the full Pu-erh Tea monograph & all interactions
Keep checking

Other Drugs & Pu-erh Tea

Browse every other medication we’ve checked against Pu-erh Tea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

9Major
447Moderate
210Minor
2,163No known interaction
9 Major 447 Moderate 210 Minor 2,163 No interaction
Major

9 interactions

Moderate

447 interactions

Showing 60 of 447 moderate interactions — see all 447 on the Pu-erh Tea page.

Minor

210 interactions

Showing 60 of 210 minor interactions — see all 210 on the Pu-erh Tea page.

No interaction 2,163 drugs checked — show the list

We also checked Pu-erh Tea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,163 medications checked with no known interaction — see the full Pu-erh Tea list.

See the full Pu-erh Tea interactions page
See every supplement checked against Guaifenesin, Phenylephrine, Phenylpropanolamine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Pu-erh Tea monograph › Uses, safety, and every drug interaction in one place Guaifenesin, Phenylephrine, Phenylpropanolamine supplement interactions › Every supplement checked against Guaifenesin, Phenylephrine, Phenylpropanolamine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Pu-erh Tea and Guaifenesin, Phenylephrine, Phenylpropanolamine Together: Common Questions

Can you take Pu-erh Tea with Guaifenesin, Phenylephrine, Phenylpropanolamine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Pu-erh Tea and Guaifenesin, Phenylephrine, Phenylpropanolamine?
Guaifenesin, Phenylephrine, Phenylpropanolamine belongs to more than one drug category, and Pu-erh Tea interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Pu-erh Tea and Guaifenesin, Phenylephrine, Phenylpropanolamine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.