Medication interaction hub

What Supplements Interact with Loncastuximab Tesirine-Lpyl?

Loncastuximab Tesirine-Lpyl brand name: Zynlontab. Every interaction below applies to the brands too.

37 Interactions 1 Major 28 Moderate 8 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Loncastuximab Tesirine-Lpyl? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Loncastuximab Tesirine-Lpyl against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Loncastuximab tesirine (Zynlonta) is an infusion treatment for lymphoma that has come back or stopped responding, so I treat anything that can shift its levels as a real safety question. All 37 ingredients on file interact through the same doorway, a transporter called P-glycoprotein that moves drugs across cell membranes. Only one, St. John's wort, is rated major, and it belongs at the top of your reading because it can push levels down and weaken a cancer treatment you cannot afford to weaken.

The other 28 moderate and 8 minor entries mostly lean the opposite way. Ginger, green tea, and similar products appear to slow that transporter, which could let the drug accumulate and raise side effect risk. Much of that evidence is lab-based, but with a lymphoma drug the margin for surprises is thin, so tell your oncology team about every supplement before your next infusion.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 28 Minor 8 No known interaction 1,415

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Loncastuximab Tesirine-Lpyl: Top Interactions at a Glance

The most significant Loncastuximab Tesirine-Lpyl supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 37 interacting ingredients — plus 1,415 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Loncastuximab Tesirine-Lpyl + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable St. John's Wort + Loncastuximab Tesirine-Lpyli

St.

Read the full interaction
The complete list

Every Supplement Checked Against Loncastuximab Tesirine-Lpyl

All 1,452 ingredients in our database, ranked by severity — 37 with a Loncastuximab Tesirine-Lpyl interaction on file and 1,415 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Loncastuximab Tesirine-Lpyl?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Eleuthero with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might increase levels of P-glycoprotein substrates.

Full Eleuthero + Loncastuximab Tesirine-Lpyl answer

Can you take Ginger with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.

Full Ginger + Loncastuximab Tesirine-Lpyl answer

Can you take Ginkgo with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with P-glycoprotein substrates might increase the levels and adverse effects of these substrates.

Full Ginkgo + Loncastuximab Tesirine-Lpyl answer

Can you take Green Tea with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Green tea might increase the levels and adverse effects of P-glycoprotein (P-gp) substrates.

Full Green Tea + Loncastuximab Tesirine-Lpyl answer

Can you take Hesperidin with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of...

Full Hesperidin + Loncastuximab Tesirine-Lpyl answer

Can you take Indian Long Pepper with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase levels of P-glycoprotein substrates.

Full Indian Long Pepper + Loncastuximab Tesirine-Lpyl answer

Can you take Kava with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if kava inhibits P-glycoprotein (P-gp); research is conflicting.

Full Kava + Loncastuximab Tesirine-Lpyl answer

Can you take Licorice with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.

Full Licorice + Loncastuximab Tesirine-Lpyl answer

Can you take Methoxylated Flavones with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that some methoxylated flavones including tangeretin, nobiletin, and heptamethoxyflavone, inhibit P-glycoprotein.

Full Methoxylated Flavones + Loncastuximab Tesirine-Lpyl answer

Can you take Moringa with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.

Full Moringa + Loncastuximab Tesirine-Lpyl answer

Can you take Neem with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.

Full Neem + Loncastuximab Tesirine-Lpyl answer

Can you take Oregon Grape with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs that are P-glycoprotein (P-gp) substrates.

Full Oregon Grape + Loncastuximab Tesirine-Lpyl answer

Can you take Quercetin with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of P-glycoprotein substrates.

Full Quercetin + Loncastuximab Tesirine-Lpyl answer

Can you take Rabdosia Rubescens with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Rabdosia rubescens might increase levels of p-glycoprotein substrates.

Full Rabdosia Rubescens + Loncastuximab Tesirine-Lpyl answer

Can you take Rhodiola with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Full Rhodiola + Loncastuximab Tesirine-Lpyl answer

Can you take Sage with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase levels of drugs transported by P-glycoprotein.

Full Sage + Loncastuximab Tesirine-Lpyl answer

Can you take Schisandra with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.

Full Schisandra + Loncastuximab Tesirine-Lpyl answer

Can you take Strawberry with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Full Strawberry + Loncastuximab Tesirine-Lpyl answer

Can you take Sweet Orange with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Full Sweet Orange + Loncastuximab Tesirine-Lpyl answer

Can you take White Pepper with Loncastuximab Tesirine-Lpyl?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white pepper might increase levels of p-glycoprotein substrates.

Full White Pepper + Loncastuximab Tesirine-Lpyl answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Loncastuximab Tesirine-Lpyl is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Loncastuximab Tesirine-Lpyl, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Loncastuximab Tesirine-Lpyl sits in 1 interaction category. Open any one to see what the group means:

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Loncastuximab Tesirine-Lpyl through this category.

About Loncastuximab Tesirine-Lpyl

Loncastuximab Tesirine-Lpyl is a prescription medication also sold under the brand name Zynlontab. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Loncastuximab Tesirine-Lpyl  ·  Brand name: Zynlontab.

See the full Loncastuximab Tesirine-lpyl Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Loncastuximab Tesirine-Lpyl

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Loncastuximab Tesirine-Lpyl.

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Products that contain Loncastuximab Tesirine-Lpyl-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Loncastuximab Tesirine-Lpyl.

Standardized St. John's Wort 600 mg by Nature's Truth contains St. John's Wort St. John's Wort-IMT by SP Standard Process contains St. John's Wort St John's Wort Extract by SuperSmart contains St. John's Wort St John's Wort 400 mg by Signature Supplements contains St. John's Wort Parabolish by Logos Nutritionals contains Goldenseal Immune Glycerite by Wise Woman Herbals contains Goldenseal Goldenseal by Herb Pharm contains Goldenseal Funga-Stop Formula by Woodstock Herbal Products contains Goldenseal Sweet Relief Glycogen Support Extreme by Justified Laboratories contains Bitter Melon Glucose Support by dr.bo contains Bitter Melon Glucofort Max by Justified Laboratories contains Bitter Melon Blood Sugar Manager by Nature's Way contains Bitter Melon Vitality by Transparent Labs contains Black Pepper Turmeric Extract 1,000 mg by Nature's Lab Gold contains Black Pepper Turmeric Curcumin Capsules by NutraChamps contains Black Pepper Turmeric Curcumin 1500 mg by O Orgeuos contains Black Pepper Bulasterone by HTP Hi-Tech Pharmaceuticals contains Bulbine Natalensis Dole Proof by 50CalLabz contains Bulbine Natalensis Black Ox by Enhanced contains Bulbine Natalensis Project Test by Anabolic Warfare contains Bulbine Natalensis
Pharmacist Counseling Corner

Loncastuximab Tesirine-Lpyl & Supplements: Common Questions

What supplements interact with Loncastuximab Tesirine-Lpyl?
More than you might expect — 37 in total, though they are far from equal: 1 are rated major, 28 moderate, and 8 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: St. John's Wort, Goldenseal, Bitter Melon.
Which Loncastuximab Tesirine-Lpyl supplement interactions are the most serious?
Focus on the major group: St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Loncastuximab Tesirine-Lpyl?
Usually yes — most people on Loncastuximab Tesirine-Lpyl can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Zynlontab have the same supplement interactions as Loncastuximab Tesirine-Lpyl?
Yes — Zynlontab all contain Loncastuximab Tesirine-Lpyl, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Loncastuximab Tesirine-Lpyl and my other medications?
This page covers Loncastuximab Tesirine-Lpyl against supplements and herbal ingredients. Checking Loncastuximab Tesirine-Lpyl against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Loncastuximab Tesirine-lpyl Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.