Medication interaction hub

What Supplements Interact with Oxaliplatin?

Oxaliplatin brand name: Eloxatin. Every interaction below applies to the brands too.

10 Interactions 8 Moderate 2 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Oxaliplatin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Oxaliplatin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Most of the ten supplements on record for oxaliplatin (Eloxatin), a chemotherapy used against colorectal cancer, are antioxidants such as vitamin C, vitamin E, and coenzyme Q10, and the concern with each is the same, that they might in theory blunt the drug's ability to kill tumor cells. None of the ten is rated major, eight sit at moderate and two at minor, and the risk is less about new side effects than about quietly undercutting your treatment, which makes this a list to watch rather than fear.

Nearly all the evidence is theoretical or from lab studies, and some of it points both ways. Still, when the medicine at stake is your cancer treatment, even a possible dent in how well it works deserves attention. Rather than guessing which antioxidant doses matter, bring your supplement bottles to your oncology pharmacist before your next infusion and sort it out together.

— , Clinical Pharmacist · July 18, 2026

Moderate 8 Minor 2 No known interaction 1,442

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Oxaliplatin: Top Interactions at a Glance

The most significant Oxaliplatin supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 10 highest-ranked of 10 interacting ingredients — plus 1,442 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Oxaliplatin + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Possible Acerola + Oxaliplatini

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full interaction Moderate Likelihood Possible Alpha-lipoic Acid + Oxaliplatini

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.

Read the full interaction Moderate Likelihood Possible Coenzyme Q10 + Oxaliplatini

Coenzyme Q10 has antioxidant effects.

Read the full interaction Moderate Likelihood Possible Dimethylsulfoxide (dmso) + Oxaliplatini

Theoretically, using DMSO as a solvent for platinum-based chemotherapeutic agents may reduce chemotherapeutic effects.

Read the full interaction Moderate Likelihood Possible Rose Hip + Oxaliplatini

Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of alkylating agents but might also reduce the oxidative damage caused by cert...

Read the full interaction Moderate Likelihood Possible Turmeric + Oxaliplatini

Turmeric has antioxidant effects.

Read the full interaction
The complete list

Every Supplement Checked Against Oxaliplatin

All 1,452 ingredients in our database, ranked by severity — 10 with a Oxaliplatin interaction on file and 1,442 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Oxaliplatin?

One-line answers, one card per combination — scroll through today’s 18 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Coenzyme Q10 with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coenzyme Q10 has antioxidant effects.

Full Coenzyme Q10 + Oxaliplatin answer

Can you take Rose Hip with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of alkylating agents but might also reduce the oxidative d...

Full Rose Hip + Oxaliplatin answer

Can you take Acerola with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Full Acerola + Oxaliplatin answer

Can you take Alpha-lipoic Acid with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.

Full Alpha-lipoic Acid + Oxaliplatin answer

Can you take Dimethylsulfoxide (dmso) with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using DMSO as a solvent for platinum-based chemotherapeutic agents may reduce chemotherapeutic effects.

Full Dimethylsulfoxide (dmso) + Oxaliplatin answer

Can you take Turmeric with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric has antioxidant effects.

Full Turmeric + Oxaliplatin answer

Can you take Vitamin C with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Full Vitamin C + Oxaliplatin answer

Can you take Vitamin E with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.

Full Vitamin E + Oxaliplatin answer

Can you take American Pawpaw with Oxaliplatin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. American pawpaw (Asimina triloba) contains Annonacin, a natural compound that has been investigated for its potential anticancer effects.

Full American Pawpaw + Oxaliplatin answer

Can you take Fish Oil with Oxaliplatin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking fish oil with platinum agents can cause resistance to platinum agents, potentially decreasing their effectiveness.

Full Fish Oil + Oxaliplatin answer

Can you take Acerola with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Full Acerola + Oxaliplatin answer

Can you take Alpha-lipoic Acid with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.

Full Alpha-lipoic Acid + Oxaliplatin answer

Can you take Dimethylsulfoxide (dmso) with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using DMSO as a solvent for platinum-based chemotherapeutic agents may reduce chemotherapeutic effects.

Full Dimethylsulfoxide (dmso) + Oxaliplatin answer

Can you take Turmeric with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric has antioxidant effects.

Full Turmeric + Oxaliplatin answer

Can you take Vitamin C with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Full Vitamin C + Oxaliplatin answer

Can you take Vitamin E with Oxaliplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.

Full Vitamin E + Oxaliplatin answer

Can you take American Pawpaw with Oxaliplatin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. American pawpaw (Asimina triloba) contains Annonacin, a natural compound that has been investigated for its potential anticancer effects.

Full American Pawpaw + Oxaliplatin answer

Can you take Fish Oil with Oxaliplatin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking fish oil with platinum agents can cause resistance to platinum agents, potentially decreasing their effectiveness.

Full Fish Oil + Oxaliplatin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Oxaliplatin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Oxaliplatin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Oxaliplatin sits in 4 interaction categories. Open any one to see what the group means:

Alkylating Agents 7 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

7 of the supplement ingredients on this page reach Oxaliplatin through this category.

Platinum Agents 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Oxaliplatin through this category.

Antineoplastics 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Oxaliplatin through this category.

Oxaliplatin (Eloxatin)

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

About Oxaliplatin

Oxaliplatin Injection is a platinum-based chemotherapy used to treat stage III colon cancer after surgery and advanced colorectal cancer.

Generic name: Oxaliplatin  ·  Brand name: Eloxatin.

See the full Oxaliplatin Injection drug information

Related: does Oxaliplatin deplete any nutrients?

Oxaliplatin has 1 reported nutrient association in the research literature — see the Oxaliplatin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Oxaliplatin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Oxaliplatin.

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Pharmacist Counseling Corner

Oxaliplatin & Supplements: Common Questions

What supplements interact with Oxaliplatin?
More than you might expect — 10 in total, though they are far from equal: 0 are rated major, 8 moderate, and 2 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Acerola, Alpha-lipoic Acid, Coenzyme Q10.
Which Oxaliplatin supplement interactions are the most serious?
None of the Oxaliplatin supplement interactions on file are currently rated major. The most significant are the 8 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Oxaliplatin?
Usually yes — most people on Oxaliplatin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Eloxatin have the same supplement interactions as Oxaliplatin?
Yes — Eloxatin all contain Oxaliplatin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Oxaliplatin deplete any vitamins or nutrients?
It might — Oxaliplatin has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Oxaliplatin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Oxaliplatin and my other medications?
This page covers Oxaliplatin against supplements and herbal ingredients. Checking Oxaliplatin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Oxaliplatin Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.