Medication interaction hub

What Supplements Interact with Bendamustine?

Bendamustine brand names: Treanda, Belrapzo, Vivimusta. Every interaction below applies to the brands too.

87 Interactions 62 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated September 26, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Bendamustine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Bendamustine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Bendamustine (Treanda, Belrapzo, Vivimusta) is IV chemotherapy for chronic lymphocytic leukemia and certain lymphomas, and the liver clears it through an enzyme called CYP1A2. That enzyme is why nearly all 87 supplements on this page appear here, since about 80 of them can push CYP1A2 up or down, which could either raise side effects or quietly blunt the dose your body actually gets. None of the 87 rates major, so for most patients these are combinations to watch and report, not hard stops.

Melatonin and CBD, two of the most common bottles in a home cabinet, sit among those that may slow the enzyme and let drug levels climb. Seven antioxidant supplements, alpha-lipoic acid among them, carry a different worry, that mopping up free radicals could dull the chemotherapy itself. Sixty-two entries rate moderate and 25 minor, most resting on lab or animal data, so hand your full supplement list to the oncology team before an infusion.

— , Clinical Pharmacist · July 18, 2026

Moderate 62 Minor 25 No known interaction 1,365

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Bendamustine: Top Interactions at a Glance

The Bendamustine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 87 interacting ingredients — plus 1,365 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Bendamustine Combinations Today

The Bendamustine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Vitamin C + Bendamustinei

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Read the full interaction Moderate Likelihood Possible Coenzyme Q10 + Bendamustinei

Coenzyme Q10 has antioxidant effects.

Read the full interaction Moderate Likelihood Possible Acerola + Bendamustinei

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full interaction Minor Likelihood Unlikely Chrysin + Bendamustinei

Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Probable Cannabidiol (cbd) + Bendamustinei

Cannabidiol may increase levels of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Probable Evodia + Bendamustinei

Evodia might reduce the levels and clinical effects of CYP1A2 substrates through induction of CYP1A2.

Read the full interaction
The complete list

Every Supplement Checked Against Bendamustine

All 1,452 ingredients in our database, ranked by severity — 87 with a Bendamustine interaction on file and 1,365 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Bendamustine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin C with Bendamustine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Full Vitamin C + Bendamustine answer

Can you take Coenzyme Q10 with Bendamustine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coenzyme Q10 has antioxidant effects.

Full Coenzyme Q10 + Bendamustine answer

Can you take Acerola with Bendamustine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Full Acerola + Bendamustine answer

Can you take Chrysin with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.

Full Chrysin + Bendamustine answer

Can you take Turmeric with Bendamustine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric has antioxidant effects.

Full Turmeric + Bendamustine answer

Can you take Vitamin E with Bendamustine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.

Full Vitamin E + Bendamustine answer

Can you take Wheatgrass with Bendamustine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Full Wheatgrass + Bendamustine answer

Can you take Zizyphus with Bendamustine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Full Zizyphus + Bendamustine answer

Can you take Aloe with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.

Full Aloe + Bendamustine answer

Can you take Ashwagandha with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.

Full Ashwagandha + Bendamustine answer

Can you take Atractylodes with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.

Full Atractylodes + Bendamustine answer

Can you take Bael with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Bael extract and its constituent marmesinin inhibited cytochrome P450 1A2 (CYP1A2) activity in vitro.

Full Bael + Bendamustine answer

Can you take Beet with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.

Full Beet + Bendamustine answer

Can you take Black Pepper with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.

Full Black Pepper + Bendamustine answer

Can you take Broccoli Sprout with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, broccoli sprout might reduce levels and effects of drugs metabolized by CYP1A2.

Full Broccoli Sprout + Bendamustine answer

Can you take Eurycoma Longifolia with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Full Eurycoma Longifolia + Bendamustine answer

Can you take German Chamomile with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Bendamustine answer

Can you take Ginger with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ginger might increase the levels of CYP1A2 substrates.

Full Ginger + Bendamustine answer

Can you take Hemp with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.

Full Hemp + Bendamustine answer

Can you take Hibiscus Sabdariffa with Bendamustine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP1A2 substrates.

Full Hibiscus Sabdariffa + Bendamustine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Bendamustine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Bendamustine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Bendamustine sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Bendamustine through this category.

Alkylating Agents 7 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

7 of the supplement ingredients on this page reach Bendamustine through this category.

Antineoplastics 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Bendamustine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Bendamustine through this category.

About Bendamustine

Bendamustine injection is a chemotherapy drug used to treat chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) in adults.

Generic name: Bendamustine  ·  Brand names: Treanda, Belrapzo, Vivimusta.

See the full Bendamustine Injection drug information

Related: does Bendamustine deplete any nutrients?

Bendamustine has 3 reported nutrient associations in the research literature — see the Bendamustine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Bendamustine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Bendamustine.

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Pharmacist Counseling Corner

Bendamustine & Supplements: Common Questions

What supplements interact with Bendamustine?
More than you might expect — 87 in total, though they are far from equal: 0 are rated major, 62 moderate, and 25 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Cannabidiol (cbd), Evodia, Melatonin.
Which Bendamustine supplement interactions are the most serious?
None of the Bendamustine supplement interactions on file are currently rated major. The most significant are the 62 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Bendamustine?
Usually yes — most people on Bendamustine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Treanda have the same supplement interactions as Bendamustine?
Yes — Treanda, Belrapzo, Vivimusta all contain Bendamustine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Bendamustine deplete any vitamins or nutrients?
It might — Bendamustine has 3 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Bendamustine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Bendamustine and my other medications?
This page covers Bendamustine against supplements and herbal ingredients. Checking Bendamustine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Bendamustine Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 26, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.