Medication interaction hub

What Supplements Interact with Tobutamide?

Tobutamide brand name: Mobenol. Every interaction below applies to the brands too.

256 Interactions 2 Major 215 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tobutamide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tobutamide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Long as this list is, it mostly tells one story, and with Tobutamide (Mobenol), a sulfonylurea that lowers blood sugar in type 2 diabetes, that story deserves genuine care. Most of the 215 moderate entries add to the drug's effect and invite hypoglycemia, the shaky, sweaty, sometimes dangerous low. Two of the 256 ingredients rate major and belong at the top of your reading: Siberian cocklebur, which has caused severe hypoglycemia in people, and activated charcoal, which binds the drug in the gut and weakens it.

A smaller group pulls the opposite way, nudging blood sugar up and blunting the pill's benefit, so an unexplained shift in your readings is worth a look at your supplement shelf. Seventeen entries mainly change how oral doses absorb; take those well apart from the tablet. The 39 minor entries carry the least weight, but with a medicine whose whole job is moving one number, testing glucose more often catches trouble early.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 215 Minor 39 No known interaction 1,196

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Tobutamide: Top Interactions at a Glance

The Tobutamide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 256 interacting ingredients — plus 1,196 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Tobutamide Combinations Today

The Tobutamide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Damiana + Tobutamidei

Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Hollyhock + Tobutamidei

Animal and in vitro research shows that hollyhock flower extracts might lower blood glucose levels.

Read the full interaction Moderate Likelihood Possible L-cysteine + Tobutamidei

Theoretically, taking L-cysteine supplements with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Minor Likelihood Possible Apple Cider Vinegar + Tobutamidei

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible European Barberry + Tobutamidei

Theoretically, taking European barberry with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Terminalia Chebula + Tobutamidei

Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Tobutamide

All 1,452 ingredients in our database, ranked by severity — 256 with a Tobutamide interaction on file and 1,196 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tobutamide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Damiana with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.

Full Damiana + Tobutamide answer

Can you take Hollyhock with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal and in vitro research shows that hollyhock flower extracts might lower blood glucose levels.

Full Hollyhock + Tobutamide answer

Can you take L-cysteine with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking L-cysteine supplements with antidiabetes drugs might increase the risk of hypoglycemia.

Full L-cysteine + Tobutamide answer

Can you take Apple Cider Vinegar with Tobutamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.

Full Apple Cider Vinegar + Tobutamide answer

Can you take European Barberry with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking European barberry with antidiabetes drugs might increase the risk of hypoglycemia.

Full European Barberry + Tobutamide answer

Can you take Terminalia Bellirica with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia bellirica with antidiabetes drugs could affect blood sugar control and increase the risk of hyp...

Full Terminalia Bellirica + Tobutamide answer

Can you take Terminalia Chebula with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypog...

Full Terminalia Chebula + Tobutamide answer

Can you take Theaflavin with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal diabetic model, giving theaflavin reduced fasting blood glucose, with an effect comparable to metformin.

Full Theaflavin + Tobutamide answer

Can you take Tinospora Cordifolia with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Tinospora Cordifolia + Tobutamide answer

Can you take Tiratricol with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tiratricol might interfere with blood glucose control.

Full Tiratricol + Tobutamide answer

Can you take Tragacanth with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Tobutamide answer

Can you take Tribulus with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Tribulus + Tobutamide answer

Can you take Tronadora with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of tronadora and antidiabetes drugs might increase the risk of hypoglycemia.

Full Tronadora + Tobutamide answer

Can you take Turkey Tail Mushroom with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turkey Tail Mushroom + Tobutamide answer

Can you take Turmeric with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turmeric with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turmeric + Tobutamide answer

Can you take Weight Watchers Diet with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Following the Weight Watchers diet while taking antidiabetes drugs may increase the risk of hypoglycemia.

Full Weight Watchers Diet + Tobutamide answer

Can you take Wheatgrass with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.

Full Wheatgrass + Tobutamide answer

Can you take White Horehound with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that white horehound might lower blood glucose.

Full White Horehound + Tobutamide answer

Can you take White Mulberry with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full White Mulberry + Tobutamide answer

Can you take White Pepper with Tobutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that piperine, a constituent of white pepper, reduces blood glucose levels.

Full White Pepper + Tobutamide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tobutamide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tobutamide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tobutamide sits in 2 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Tobutamide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Tobutamide through this category.

Related: does Tobutamide deplete any nutrients?

Tobutamide has 1 reported nutrient association in the research literature — see the Tobutamide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tobutamide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tobutamide.

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Pharmacist Counseling Corner

Tobutamide & Supplements: Common Questions

What supplements interact with Tobutamide?
Our database currently documents 256 ingredients with a known Tobutamide interaction (2 major, 215 moderate, 39 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 256. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Tobutamide supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Tobutamide?
Plenty of supplements coexist fine with Tobutamide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Mobenol have the same supplement interactions as Tobutamide?
Yes — Mobenol all contain Tobutamide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Tobutamide deplete any vitamins or nutrients?
It might — Tobutamide has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Tobutamide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Tobutamide and my other medications?
This page covers Tobutamide against supplements and herbal ingredients. Checking Tobutamide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.