Arjuna 500 mg Ingredients & Drug Interactions
by Herbal Hills
What is this page for?
First and foremost: checking Arjuna 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Arjuna 500 mg is a dietary supplement by Herbal Hills with 1 active ingredient. Its ingredients are commonly taken for heart health and circulation, digestive problems (constipation, diarrhea), cholesterol support.Based on those ingredients, 933 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Arjuna Bark Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Arjuna 500 mg by Herbal Hills
Ask about any prescription or over-the-counter medication and we check it for interactions with Arjuna 500 mg by Herbal Hills — and tell you which ingredient is responsible.
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HelloPharmacist Scorecard of Arjuna 500 mg by Herbal Hills
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
None of the active ingredients could be matched to our evidence database, so intended use can't be graded.
Why this rating?
- None of the active ingredients could be matched to a HelloPharmacist monograph, so intended use can't be graded against our evidence data.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 1 of its 1 active ingredient.
- “Arjuna Bark Extract” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.
None of the active ingredients could be matched to our interaction database.
Why this rating?
- We couldn't match any ingredient to a HelloPharmacist monograph, so there was nothing to check interactions against.
None of the active ingredients could be matched to our safety data.
Why this rating?
- We couldn't match any ingredient to a HelloPharmacist monograph, so there was no safety data to measure.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Medication interactions could not be assessed, and safety information could not be assessed.
Assessment coverage: 0 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Arjuna 500 mg, straight from the product label.
| Brand | Herbal Hills |
|---|---|
| Barcode (UPC) | 8904268808502 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 24, 2023 |
| DSLD ID | 296402 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Halal |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Arjuna 500 mg by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Arjuna Bark Extract | 500 mg | -- |
| Arjunolic Acid | 2.5 mg | -- |
Other ingredients: Veggie capsule, Vegetable Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions for use: As a dietary supplement, take 1 veggie capsule 3 times a day with meals or as directed by your health care practitioner.
Precautions
Warning: Pregnant or lactating women are advised to consume herbal products under the advice of the healthcare practitioner.
Keep out of reach of children.
Do not use if pouch is broken.
Please consult an expert before use.
Storage
Storage: Store in a cool dry place away from direct sunlight.
Formulation
Being natural product. Colour may vary over time as well as from batch to batch however effectiveness remains the same.
Country of Origin: India
FDA Statement of Identity
This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
Herbal Hills Back to Nature
General Statements
Neutral Code: MH/PD/AYU/002/10
Seals/Symbols
QA ICS JAS-ANZ ISO 22000:2005 Reg. No.: RH91/7301 GMP Good Manufacturing Practice Halal India www.Halalindia.com HIW21081110
Formula
Halal India www.Halalindia.com HIW21081110
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Arjuna 500 mg by Herbal Hills label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Arjuna 500 mg by Herbal Hills
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
Arjuna Bark Extract
Interacts with933 drugs
Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes....
Arjuna Bark Extract monograph & interactions- › Arjunolic Acid
Other (inactive) ingredients: Veggie capsule, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.
Arjuna 500 mg by Herbal Hills Drug Interactions
Arjuna 500 mg contains a single active ingredient, and it has known interactions with 933 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Arjuna 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Arjuna 500 mg interact with 933 drugs. Click any drug to see the details.
1 of the 1 ingredient in Arjuna 500 mg interact with drugs. Each result below shows which ingredient is responsible. Arjuna Bark Extract
Antithrombin IiiThrombate III
How Antithrombin Iii interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Antithrombin Iii interactionApalutamideErleada
How Apalutamide interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna Bark Extract + Apalutamide interactionApixabanEliquis
How Apixaban interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Apixaban interactionApremilastOtezla
How Apremilast interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna Bark Extract + Apremilast interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna Bark Extract + Aprepitant interactionArgatrobanArgatroban
How Argatroban interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Argatroban interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna Bark Extract + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Arjuna Bark Extract + Aripiprazole Lauroxil interactionArmodafinilNuvigil
How Armodafinil interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna Bark Extract + Armodafinil interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna Bark Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna Bark Extract + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Arjuna Bark Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna Bark Extract + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium OxideBufferin
How Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionAspirin, CarisoprodolSoma Compound
How Aspirin, Carisoprodol interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Carisoprodol interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, Citric Acid, Sodium BicarbonateAlka-Seltzer Pain Reliever and Antacid
How Aspirin, Citric Acid, Sodium Bicarbonate interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Citric Acid, Sodium Bicarbonate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna Bark Extract + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Arjuna 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Arjuna Bark ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Arjuna Bark Extract + Aspirin, Codeine Phosphate, Methocarbamol interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Arjuna 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Arjuna Bark Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
In vitro, Terminalia arjuna bark extract inhibits platelet aggregation, decreases platelet activation, and shows antithrombotic properties.
Antidiabetes Drugs
Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Animal and in vitro research shows that Terminalia bellirica and Terminalia chebula fruit and seed extract have hypoglycemic effects.
Chlorzoxazone (Parafon Forte, Paraflex)
Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of chlorzoxazone increases blood levels of chlorzoxazone and decreases chlorzoxazone clearance. It is speculated that Terminalia chebula reduces the metabolism of chlorzoxazone by inhibiting cytochrome P450 2E1.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2C9 enzymes and reduces CYP2C9 substrate metabolism.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2D6 enzymes and reduces CYP2D6 substrate metabolism.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP3A4 enzymes and reduces CYP3A4 substrate metabolism.
Omeprazole (Prilosec)
Theoretically, use of Terminalia chebula may increase the risk of adverse effects from omeprazole.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of omeprazole increases blood levels of omeprazole and decreases omeprazole clearance. It is speculated that Terminalia chebula reduces the metabolism of omeprazole by inhibiting cytochrome P450 2C19.
Brand information
Manufacturer and brand details for Arjuna 500 mg, from the product label.
Arjuna 500 mg by Herbal Hills: Common Questions
Does Arjuna 500 mg by Herbal Hills interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Arjuna 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Arjuna 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Arjuna 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 9 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Terminalia 9 references
- Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
- Rao, N. K. and Nammi, S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC.Complement Altern.Med 2006;6:17. PubMed
- Murali, Y. K., Anand, P., Tandon, V., Singh, R., Chandra, R., and Murthy, P. S. Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced
- Senthilkumar, G. P. and Subramanian, S. Evaluation of antioxidant potential of Terminalia chebula fruits studies in streptozotocin-induced diabetic rats. Pharmaceutical Biology (Netherlands) 2007;45:511-518.
- Malik N, Dhawan V, Bahl A, Kaul D. Inihbitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease. Platelets. 2009;20(3):183-1190.
- Varghese A, Savai J, Pandita N, Gaud RS. In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin, and arjungenin on CYP3A4, CYP2D6, and CYP2C9 enzyme activity in human liver microsomes. Toxicology Reports. 2015(2):806-16. PubMed
- Wu G, Dong Z, Dong J, et al. Effects of mongolian medicine Terminalia chebula Retz. on 6 CYP450 enzymes in rats. Int J Clin Exp Pathol 2020;13(12):3128-3138.
- Das A, Naveen J, Sreerama YN, Gnanesh Kumar BS, Baskaran V. Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit a-amylase, a-glucosidase and DPP-IV activity in high fat and low dose st
- Eltimamy M, Elshamarka M, Aboelsaad M, Sayed M, Moawad H. Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats. J Diabetes Metab Disord 2022;21(1):159-170. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC