Ashwagandha SAP Ingredients & Drug Interactions
by NFH
What is this page for?
First and foremost: checking Ashwagandha SAP against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ashwagandha SAP is a dietary supplement by NFH with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ashwagandha SAP by NFH
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HelloPharmacist Scorecard of Ashwagandha SAP by NFH
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: ashwagandha root extract. It also includes several inactive ingredients—vegetable magnesium stearate, silicon dioxide, vegetable hypromellose, and purified water—which serve as binders, flow agents, and capsule material.
Does it work?
Moderate evidence
According to our data, ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD). The evidence for its use in bipolar disorder is insufficient to rate.
These ratings reflect preliminary clinical research; larger and longer studies are still needed to confirm how well it works.
How safe is it?
Well-documented data
Ashwagandha is generally well tolerated in the short term for healthy adults, though long-term safety data are limited. The most common side effects when taken by mouth are diarrhea, gastrointestinal upset, nausea, and vomiting—but these don't typically occur at standard doses.
Drowsiness has been reported. Rare serious adverse effects include acute liver injury, hepatitis, and liver failure; case reports also describe intracranial bleeding and reversible cerebral vasoconstriction syndrome in individuals taking ashwagandha alongside other medications.
The safety data advises against ashwagandha during pregnancy due to traditional concern for miscarriage. There isn't enough safety information to recommend it while breastfeeding—talk with your pharmacist or doctor about whether it's right for you if you're nursing.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your pharmacist if you take any hepatotoxic drugs (medications that can harm the liver), CNS depressants or benzodiazepines (sedatives, anti-anxiety drugs), blood pressure medications, blood sugar medications, thyroid hormones, immunosuppressants, or drugs metabolized by the CYP1A2 enzyme. Altogether, these interactions span 1,351 individual medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Ashwagandha SAP may help with insomnia, anxiety, and stress based on preliminary evidence. If you take medications for blood pressure, blood sugar, sleep, anxiety, thyroid function, immune suppression, or liver health, or if you take benzodiazepines, check with your pharmacist first.
Pregnant and nursing individuals should avoid this product. For personalized advice, run your medications through the interaction checker on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ashwagandha SAP, straight from the product label.
| Brand | NFH |
|---|---|
| Barcode (UPC) | 856711111593 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2023 |
| DSLD ID | 273574 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ashwagandha SAP by NFH, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Ashwagandha Root Extract | 500 mg | -- |
Other ingredients: Vegetable Magnesium Stearate, Silicon Dioxide, Vegetable Hypromellose, Water, Purified
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Ashwagandha SAP is traditionally used in ayurveda for memory enhancement; to balance aggravated vata (nervine tonic, sedative); as a sleep aid; as rasayana (rejuvenate tonic); and to relive general debility, especially during convalescence or old age. Ashwagandha SAP helps increase resistance to stress. Athletic support or workout / exercise supplement. Ashwagandha SAP helps promote healthy testosterone production in males, and support physical aspects of sexual health in women.
All ingredients listed for this product lot number have been tested by a third-party laboratory for identity, potency, and purity.
Contains no: Gluten, soy, wheat, corn, eggs, dairy, yeast, citrus, preservatives, artificial flavor or color, starch, or sugar.
This product is non-GMO and vegan friendly.
This product is non-GMO and vegan friendly.
Color, size and smell may vary from one lot to another.
Stress support
Made in Canada
Suggested/Recommended/Usage/Directions
Directions for use: Adults: Take 1 capsule daily or as directed by your healthcare practitioner.
Precautions
Cautions and warnings: Consult a healthcare practitioner prior to use if you are pregnant or breast-feeding; if you have benign prostate hypertrophy and / or prostate cancer; if you have been diagnoses with hypoactive sexual disorder, or sexual or erectile dysfunction; or if you suffer from any psychological disorder and/ or condition such as anxiety or depression.
Known adverse reactions: Consumption with alcohol, other drugs, or natural health products with sedative properties is not recommended.
Do not use if seal is broken.
Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, trat, cure, or prevent an disease.
FDA Statement of Identity
Dietary Supplement
General Statements
NPN 80086432
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ashwagandha SAP by NFH label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ashwagandha SAP by NFH
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Ashwagandha Root Extract
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Ashwagandha Root Extract monograph & interactionsOther (inactive) ingredients: Vegetable Magnesium Stearate, Silicon Dioxide, Vegetable Hypromellose, Water, Purified. These complete the product’s ingredient list but are not active constituents.
Ashwagandha SAP by NFH Drug Interactions
HelloPharmacist Interaction Report
Ashwagandha SAP from NFH contains a single active ingredient—ashwagandha root extract—that interacts with a substantial number of medications.
The most serious concern is liver damage: ashwagandha has been linked to acute hepatitis, liver failure, and in rare cases the need for transplantation. This risk is Moderate in severity and applies to any hepatotoxic drugs (medications that can injure the liver).
Read the full breakdown — every affected drug type, severity by severity
Ashwagandha also carries Moderate-severity interactions with several other drug types. It may increase sedation when combined with CNS depressants (sedatives, barbiturates, anxiolytics) or benzodiazepines.
It could lower blood pressure too much if you're already on antihypertensive drugs. It may increase your risk of low blood sugar (hypoglycemia) if you take antidiabetes medications.
It might boost thyroid hormone effects and side effects. And it could theoretically reduce the effectiveness of immunosuppressants used after transplant or for autoimmune conditions.
Ashwagandha also has a Minor interaction with certain drugs that your liver breaks down using the CYP1A2 enzyme pathway—it may decrease their levels and effectiveness. We hold no data on whether ashwagandha interacts with any other medications its ingredients are used with.
Although these are theoretical risks, they warrant a careful check of your exact medications using the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ashwagandha SAP?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ashwagandha SAP interact with 1,372 drugs. Click any drug to see the details.
1 of the 1 ingredient in Ashwagandha SAP interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha Root Extract
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Abemaciclib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Acalabrutinib interactionAgomelatineValdoxan
How Agomelatine interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root Extract + Agomelatine interactionAlfuzosinUroxatral
How Alfuzosin interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Alfuzosin interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractSerotonergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract + Almotriptan interactionAlosetronLotronex
How Alosetron interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractSerotonergic Drugs Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract + Alosetron interactionAlpelisibPiqray
How Alpelisib interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Alpelisib interactionAmoxapineAsendin
How Amoxapine interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractSerotonergic Drugs Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract + Amoxapine interactionAmphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine SulfateAdderall, Adderall XR
How Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractSerotonergic Drugs Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract + Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interactionAmprenavirAgenerase
How Amprenavir interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Amprenavir interactionAnagrelideAgrylin
How Anagrelide interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root Extract + Anagrelide interactionApalutamideErleada
How Apalutamide interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Apalutamide interactionApixabanEliquis
How Apixaban interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Apixaban interactionApremilastOtezla
How Apremilast interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Apremilast interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Aprepitant interactionArmodafinilNuvigil
How Armodafinil interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Armodafinil interactionAsenapineSaphris, Secuado
How Asenapine interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root Extract + Asenapine interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root Extract + Aspirin, Caffeine interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root Extract + Aspirin, Caffeine, Orphenadrine interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractSerotonergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Aspirin, Omeprazole interactionAtazanavirReyataz
How Atazanavir interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Atazanavir interactionAtazanavir, CobicistatEvotaz
How Atazanavir, Cobicistat interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Atazanavir, Cobicistat interactionAtogepantQulipta
How Atogepant interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Atogepant interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, PhenylAtrosept
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interacts with Ashwagandha SAP — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractSerotonergic Drugs Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ashwagandha SAP with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Ashwagandha Root Extract
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Brand information
Manufacturer and brand details for Ashwagandha SAP, from the product label.
NFH
See all NFH products- Name
- NFH - Nutritional Fundamentals for Health, Inc.
- Street Address
- 351 Rue Joseph-Carrier
- City
- Vaudreuil
- State
- QC
- ZipCode
- J7V 5V5
- Phone Number
- 1 866 510-3123
- Web Address
- nfh.ca
Ashwagandha SAP by NFH: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Ashwagandha SAP is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ashwagandha SAP’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Ashwagandha SAP's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ashwagandha 32 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
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