Interactions on record — worth a quick check against your medications. Based on 7 of 10 ingredients. Check your meds →
Dietary supplement

Children's ProBio SAP Ingredients & Drug Interactions

by NFH

Children's ProBio SAP label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Children's ProBio SAP against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Children's ProBio SAP is a dietary supplement by NFH with 10 active ingredients. Its ingredients are commonly taken for digestive health and regularity, infant colic and gut support, diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium breve R0070, Bifidobacterium longum R0175, Lacticaseibacillus rhamnosus R0011. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Children's ProBio SAP by NFH

Ask about any prescription or over-the-counter medication and we check it for interactions with Children's ProBio SAP by NFH — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Children's ProBio SAP by NFH

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.

Children's ProBio SAP contains 10 active probiotic bacterial strains: Bifidobacterium breve, Bifidobacterium longum, Lacticaseibacillus rhamnosus (two strains), Bifidobacterium infantis, Lactobacillus helveticus, Lactiplantibacillus plantarum, Lacticaseibacillus casei, Streptococcus salivarius ssp. thermophilus, and Lactobacillus delbrueckii ssp. bulgaricus. These are live-culture probiotics meant to support the child's gut bacteria.

The powder also contains inactive ingredients including potato starch, ascorbic acid (vitamin C), inulin, arabinogalactan, and vegetable magnesium stearate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promote gastrointestinal and immune health in children.
  • We looked for evidence on: Antibiotic-associated diarrhea, Atopic dermatitis (eczema), Atopic disease, Child development, Colic, Clostridioides difficile infection — and 4 related terms.
  • The strongest evidence on file: Lacticaseibacillus Rhamnosus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lacticaseibacillus Rhamnosus is rated "Possibly Effective" for Atopic disease, Atopic dermatitis (eczema).
  • Also on file: Lactiplantibacillus Plantarum is rated "Possibly Effective" for Common cold, Atopic dermatitis (eczema).

The evidence for these strains in children is mixed and often limited. Lacticaseibacillus rhamnosus and Lactiplantibacillus plantarum are rated possibly effective for atopic dermatitis (eczema) and antibiotic-associated diarrhea.

Lactiplantibacillus plantarum also shows possibly effective evidence for high cholesterol, ulcerative colitis, and the common cold. For most other claimed uses—allergic rhinitis, asthma, cognitive function, depression, and others—the evidence we hold is insufficient to rate effectiveness.

You'll want to talk with your child's doctor about whether this product is a good fit for your child's specific needs.

The evidence, ingredient by ingredient Bifidobacterium Breve Bifidobacterium Longum Lacticaseibacillus Rhamnosus Lactobacillus Helveticus Lactiplantibacillus Plantarum Lacticaseibacillus Casei Lactobacillus Delbrueckii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These probiotic strains are generally well tolerated in healthy children. However, limited safety data exist overall, and you should check with your child's healthcare provider before use.

Gastrointestinal side effects like bloating, flatulence, and diarrhea have been reported rarely with some strains. More seriously, rare cases of bacteremia and sepsis caused by these probiotic bacteria have occurred in critically ill infants and children, particularly premature infants in hospital settings or those who are severely immunocompromised.

For pregnancy and breastfeeding, Lacticaseibacillus rhamnosus and Lacticaseibacillus casei are rated possibly safe; Bifidobacterium longum is rated possibly safe for both; and data for the other strains are not on file.

Side effects, ingredient by ingredient Bifidobacterium Breve Bifidobacterium Longum Lacticaseibacillus Rhamnosus Lactobacillus Helveticus Lactiplantibacillus Plantarum Lacticaseibacillus Casei Lactobacillus Delbrueckii

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Bifidobacterium Breve, Bifidobacterium Longum, Lacticaseibacillus Casei, Lacticaseibacillus Rhamnosus, Lactiplantibacillus Plantarum, among others.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If your child takes any antibiotic medication, do not give this probiotic at the same time. Space them several hours apart so the antibiotic doesn't kill the live organisms in the powder.

Use the medication checker on this page to identify any antibiotics before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a multi-strain probiotic for children formulated with live bacteria. It's generally well tolerated in healthy kids, but it's not right for every child—particularly those who are critically ill or have weakened immune systems.

Before you start it, check with your child's doctor or pharmacist, especially if your child is taking antibiotics (timing matters). If your child has any serious illness or is in intensive care, this needs a healthcare provider's approval.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Children's ProBio SAP, straight from the product label.

Brand NFH
Barcode (UPC) 856711001795
Net contents 1.1 Ounce(s); 30 Gram(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 273248
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children (All), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Children's ProBio SAP by NFH, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Scoop(s)
Maximum serving Sizes:
2 Scoop(s)
Servings per container
120
UPC/BARCODE
856711001795
IngredientAmount% DV
Bifidobacterium breve R00700 NP--
Bifidobacterium longum R01750 NP--
Lacticaseibacillus rhamnosus R00110 NP--
Lacticaseibacillus rhamnosus R10390 NP--
Bifidobacterium infantis R00330 NP--
Lactobacillus Helveticus R00520 NP--
Lactiplantibacillus plantarum R10120 NP--
Lacticaseibacillus casei R02150 NP--
Streptococcus salivarius ssp. thermophilus R00830 NP--
Lactobacillus delbrueckii ssp. bulgaricus R90010 NP--

Other ingredients: Potato Starch, Ascorbic Acid, Inulin, Arabinogalactan, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Provides live microorganisms that temporarily modify gut flora.

All ingredients listed for this product lot number have been tested by a third-party laboratory for identity, potency, and purity.

Contains no: Gluten, wheat, corn, eggs, yeast, citrus, preservatives, artificial flavor or color, or sugar.

This product is non-GMO.

Color and smell may vary from one lot to another.

Digestive and immune support

Made in Canada

Formula

Children's ProBio SAP supplies a high-dose, multistrain probiotic blend to promote a wide spectrum of gastrointestinal and immune health effects during childhood development.

10 billion CFU per serving

Suggested/Recommended/Usage/Directions

Directions for use: Children 1 year and older: Take 2 scoops daily (250 mg) in cold food and consume immediately or as directed by your healthcare practitioner. If you are taking antibiotics, take this product at least 2-3 hours before or after them.

Precautions

For younger children: Consult a healthcare practitioner for directions.

Cautions and warnings: Consult a healthcare practitioner prior to use if you have nausea, fever, vomiting, bloody diarrhea or severe abdominal pain. Discontinue use and consult a healthcare practitioner if symptoms of digestive upset (e.g. diarrhea) occur, worsen, or persist beyond 3 days.

Contraindications: This product has come into contact with milk and soy. Do not use if you have a milk or soy allergy, or an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatments).

Do not use if seal is broken.

Keep out of reach of children.

Storage

Keep refrigerated

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

CFU = colony-forming units

NPN 80067725

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Children's ProBio SAP by NFH label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Children's ProBio SAP label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Children's ProBio SAP by NFH

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Scoop(s) Dosage formPowder Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bifidobacterium breve R0070

Interacts with
182 drugs
0 NP per serving

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies...

Bifidobacterium breve R0070 monograph & interactions

Bifidobacterium longum R0175

Interacts with
182 drugs
0 NP per serving

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most...

Bifidobacterium longum R0175 monograph & interactions

Lacticaseibacillus rhamnosus R0011

Interacts with
182 drugs
0 NP per serving

Lacticaseibacillus rhamnosus (often labeled L. rhamnosus GG) is a well-studied probiotic bacterium used mainly for diarrhea and general gut health. It...

Lacticaseibacillus rhamnosus R0011 monograph & interactions

Lacticaseibacillus rhamnosus R1039

Interacts with
182 drugs
0 NP per serving

Lacticaseibacillus rhamnosus (often labeled L. rhamnosus GG) is a well-studied probiotic bacterium used mainly for diarrhea and general gut health. It...

Lacticaseibacillus rhamnosus R1039 monograph & interactions

Bifidobacterium infantis R0033

0 NP per serving

Lactobacillus Helveticus R0052

Interacts with
182 drugs
0 NP per serving

Lactobacillus helveticus is a lactic acid bacterium used as a probiotic, often combined with other strains in mood, gut, and general wellness products...

Lactobacillus Helveticus R0052 monograph & interactions

Lactiplantibacillus plantarum R1012

Interacts with
182 drugs
0 NP per serving

Lactiplantibacillus plantarum is a 'friendly' bacterium (probiotic) found in fermented foods and many supplements, studied mainly for digestive health...

Lactiplantibacillus plantarum R1012 monograph & interactions

Lacticaseibacillus casei R0215

Interacts with
182 drugs
0 NP per serving

Lacticaseibacillus casei (formerly Lactobacillus casei) is a 'friendly' probiotic bacterium found in fermented foods and many supplements. It is most...

Lacticaseibacillus casei R0215 monograph & interactions

Streptococcus salivarius ssp. thermophilus R0083

0 NP per serving

Lactobacillus delbrueckii ssp. bulgaricus R9001

Interacts with
182 drugs
0 NP per serving

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is g...

Lactobacillus delbrueckii ssp. bulgaricus R9001 monograph & interactions

Other (inactive) ingredients: Potato Starch, Ascorbic Acid, Inulin, Arabinogalactan, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Children's ProBio SAP by NFH Drug Interactions

Want to check YOUR meds against Children's ProBio SAP?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium breve R0070 182
Bifidobacterium longum R0175 182
Lacticaseibacillus rhamnosus R0011 182
Lactobacillus Helveticus R0052 182
Lactiplantibacillus plantarum R1012 182

Individual Drug Interactions

The ingredients in Children's ProBio SAP interact with 182 drugs. Click any drug to see the details.

7 of the 10 ingredients in Children's ProBio SAP interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium breve R0070 Bifidobacterium longum R0175 Lacticaseibacillus rhamnosus R0011 Lactobacillus Helveticus R0052 Lactiplantibacillus plantarum R1012 Lacticaseibacillus casei R0215 Lactobacillus delbrueckii ssp. bulgaricus R9001

Each ingredient & the kinds of drugs it affects

For each ingredient in Children's ProBio SAP with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium breve R00701 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium breve R0070 full monograph & interactions

Bifidobacterium longum R01751 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum R0175 full monograph & interactions

Lacticaseibacillus rhamnosus R00111 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L. rhamnosus.
L. rhamnosus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. rhamnosus preparations by at least two hours.

Likelihood Probable Evidence D
Lacticaseibacillus rhamnosus R0011 full monograph & interactions

Lactobacillus Helveticus R00521 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L. helveticus.
Lactobacillus helveticus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. helveticus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus Helveticus R0052 full monograph & interactions

Lactiplantibacillus plantarum R10121 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L. plantarum.
L. plantarum preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. plantarum preparations by at least two hours.

Likelihood Probable Evidence D
Lactiplantibacillus plantarum R1012 full monograph & interactions

Lacticaseibacillus casei R02151 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lacticaseibacillus casei with antibiotic drugs might decrease the effectiveness of L. casei.
L. casei preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. casei preparations by at least two hours.

Likelihood Probable Evidence D
Lacticaseibacillus casei R0215 full monograph & interactions

Lactobacillus delbrueckii ssp. bulgaricus R90011 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus delbrueckii ssp. bulgaricus R9001 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Children's ProBio SAP, from the product label.

NFH

See all NFH products
Name
NFH - Nutritional Fundamentals for Health, Inc.
Street Address
351 Rue Joseph-Carrier
City
Vaudreuil
State
QC
ZipCode
J7V 5V5
Phone Number
1 866 510-3123
Web Address
nfh.ca
Pharmacist Counseling Corner

Children's ProBio SAP by NFH: Common Questions

Does Children's ProBio SAP by NFH interact with any medications?
Yes. Based on its ingredients, Children's ProBio SAP has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Children's ProBio SAP contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can my child take this while on an antibiotic?
Not at the same time. Antibiotics kill the live bacteria in this probiotic, making it less effective. Separate them—ask your pharmacist how many hours apart. For example, you might give the antibiotic in the morning and the probiotic in the evening.
Does this product have any common side effects?
Bloating, flatulence, and diarrhea have been reported rarely with probiotics. Most children tolerate this product well. If your child has stomach pain or loose stools, mention it to your pediatrician.
Is it safe for infants?
Premature infants and very young infants in intensive care have rarely developed serious infections from probiotic use. If your infant is in the hospital or has a weakened immune system, you need your child's doctor's approval before starting this. Healthy infants may tolerate it, but always check first.
Will this help my child's eczema?
Two of the strains—Lacticaseibacillus rhamnosus and Lactiplantibacillus plantarum—are rated possibly effective for atopic dermatitis (eczema). That doesn't mean it will work for every child, so talk to your pediatrician about whether it's worth trying for your child's specific skin condition.
What does this powder contain besides the probiotics?
It has potato starch, ascorbic acid (vitamin C), inulin, arabinogalactan, and vegetable magnesium stearate as inactive ingredients. These are fillers and binders that help the product mix and stay stable.
Is it okay if I'm breastfeeding?
Lacticaseibacillus rhamnosus and Bifidobacterium longum are rated possibly safe during breastfeeding. Data for the other strains aren't on file. If you're nursing and thinking about taking this yourself, check with your healthcare provider for personalized advice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Children's ProBio SAP is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Children's ProBio SAP label
Go deeper

The Full Monographs Behind Children's ProBio SAP’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Lacticaseibacillus Rhamnosus

Interacts with 182 drugs

Lacticaseibacillus rhamnosus (often labeled L. rhamnosus GG) is a well-studied probiotic bacterium used mainly for diarrhea and general gut health. It is considered safe for most healthy peo...

Read the full Lacticaseibacillus Rhamnosus monograph → Herb & supplement monograph

Lactobacillus Helveticus

Interacts with 182 drugs

Lactobacillus helveticus is a lactic acid bacterium used as a probiotic, often combined with other strains in mood, gut, and general wellness products. Early research is interesting—especial...

Read the full Lactobacillus Helveticus monograph → Herb & supplement monograph

Lactiplantibacillus Plantarum

Interacts with 182 drugs

Lactiplantibacillus plantarum is a 'friendly' bacterium (probiotic) found in fermented foods and many supplements, studied mainly for digestive health. It is generally well tolerated in heal...

Read the full Lactiplantibacillus Plantarum monograph → Herb & supplement monograph

Lacticaseibacillus Casei

Interacts with 182 drugs

Lacticaseibacillus casei (formerly Lactobacillus casei) is a 'friendly' probiotic bacterium found in fermented foods and many supplements. It is most studied for digestive issues like diarrh...

Read the full Lacticaseibacillus Casei monograph → Herb & supplement monograph

Lactobacillus Delbrueckii

Interacts with 182 drugs

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy peo...

Read the full Lactobacillus Delbrueckii monograph →
Sources

Sources & How We Checked

Children's ProBio SAP's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 97 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
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Lacticaseibacillus Rhamnosus 34 references
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Lactobacillus Helveticus 2 references
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  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

See these in context on the Lactobacillus Helveticus monograph →

Lactiplantibacillus Plantarum 12 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Ducrotté P, Sawant P, Jayanthi V. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol 2012;18(30):4012-8.
  3. Krag A, Munkholm P, Israelsen H, von Ryberg B, Andersen KK, Bendtsen F. Profermin is efficacious in patients with active ulcerative colitis--a randomized controlled trial. Inflamm Bowel Dis. 2013;19(12):2584-92. PubMed
  4. Topcuoglu S, Gursoy T, Ovali F, Serce O, Karatekin G. A new risk factor for neonatal vancomycin-resistant Enterococcus colonisation: bacterial probiotics. J Matern Fetal Neonatal Med. 2015;28(12):1491-4. PubMed
  5. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
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  7. Axling U, Önning G, Martinsson Niskanen T, Larsson N, Hansson SR, Hulthén L. The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial. Acta Obstet Gynecol Scand
  8. Matsuura H, Kiura Y, Ito T, et al. Lactobacillus bacteremia: a diagnostic clue of rectal cancer. QJM. 2021;114(2):122-123. PubMed
  9. Lazou Ahrén I, Berggren A, Teixeira C, Martinsson Niskanen T, Larsson N. Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, doub
  10. Busch R, Gruenwald J, Dudek S. Randomized, double blind and placebo controlled study using a combination of two probiotic lactobacilli to alleviate symptoms and frequency of common cold. Food Nutr Sci 2013;4(11A):13-2. DOI
  11. Bengtsson J, Adlerberth I, Östblom A, Saksena P, Öresland T, Börjesson L. Effect of probiotics (Lactobacillus plantarum 299 plus Bifidobacterium Cure21) in patients with poor ileal pouch function: a randomised controlled trial. Scand J Gastroenterol 2016;
  12. Canaviri-Paz P, Oscarsson E, Kjellström A, Olsson H, Jois C, Håkansson Å. Effects on Microbiota Composition after Consumption of Quinoa Beverage Fermented by a Novel Xylose-Metabolizing L. plantarum Strain. Nutrients 2021;13(10):3318. PubMed

See these in context on the Lactiplantibacillus Plantarum monograph →

Lacticaseibacillus Casei 10 references
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  2. Orkaby AR, Chen B, Iliaki EF, Sulis CA, Oates DJ. A curious case of Lactobacillus casei in a prosthetic joint: was it the yogurt? J Am Geriatr Soc. 2012;60(6):1177-8.
  3. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
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  5. Topcuoglu S, Gursoy T, Ovali F, Serce O, Karatekin G. A new risk factor for neonatal vancomycin-resistant Enterococcus colonisation: bacterial probiotics. J Matern Fetal Neonatal Med. 2015;28(12):1491-4. PubMed
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Lactobacillus Delbrueckii 9 references
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  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  6. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  7. Neonakis IK, Skamagkas I, Stafylaki D, Maraki S. Lactobacillus delbrueckii urinary tract infection in a male patient: a case report. Germs 2022;12(2):304-307. PubMed
  8. Maillet F, Passeron A, Podglajen I, Ranque B, Pouchot J. Lactobacillus delbrueckii urinary tract infection in a male patient. Med Mal Infect 2019;49(3):226-228. PubMed
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See these in context on the Lactobacillus Delbrueckii monograph →

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