Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

BCAA Stack Orange Splash Ingredients & Drug Interactions

by Universal

BCAA Stack Orange Splash label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking BCAA Stack Orange Splash against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

BCAA Stack Orange Splash is a dietary supplement by Universal with 4 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against BCAA Stack Orange Splash by Universal

Ask about any prescription or over-the-counter medication and we check it for interactions with BCAA Stack Orange Splash by Universal — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of BCAA Stack Orange Splash by Universal

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains 4 active ingredients: glutamine and three branched-chain amino acids (BCAAs) — leucine, isoleucine, and valine. Amino acids are the building blocks your body uses to make proteins and perform vital functions.

The product also contains several inactive ingredients — citric acid, orange flavoring, aspartame, and annatto — which serve as flavor, sweetener, and color.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle recovery and anti-catabolic support during training.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Critical illness (trauma), HIV/AIDS-related wasting, Muscular dystrophy — and 3 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for HIV/AIDS-related wasting (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma), Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance, Muscular dystrophy.

Glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and recovery from critical illness or trauma. The effectiveness data we hold doesn't cover the BCAAs (leucine, isoleucine, valine) in this product; evidence for those ingredients isn't established in our records.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glutamine is rated likely safe in pregnancy and lactation. In healthy adults, it's generally well tolerated, though people with kidney or liver disease should use it only under medical supervision.

The most common side effects are gastrointestinal — belching, bloating, constipation, diarrhea, flatulence, and nausea — especially at high doses. Headache, dizziness, and musculoskeletal pain have also been reported.

Rare cases of mania or hypomania have occurred in people with bipolar disorder. Because safety information for leucine, isoleucine, and valine is not on file, talk with your doctor or pharmacist if you're pregnant, breastfeeding, or have concerns about those ingredients.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsant medications (seizure drugs), double-check with your doctor or pharmacist before starting this product — glutamine may theoretically interfere with their effectiveness. For leucine, isoleucine, and valine, no interactions are documented in the data we hold, though we were unable to check them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This BCAA supplement may be worth considering if you're looking to support muscle recovery or protein intake, but if you take seizure medications, check with your doctor or pharmacist first — glutamine could potentially interfere with how they work. Anyone with kidney or liver disease should discuss it with their healthcare provider before starting.

Your doctor or pharmacist can help you decide if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BCAA Stack Orange Splash, straight from the product label.

Brand Universal
Barcode (UPC) 039442052087
Net contents 2.2 lb; 1 kg
Market status On market
Date entered into DSLD Aug 24, 2016
DSLD ID 64178
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BCAA Stack Orange Splash by Universal, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
9.34 Gram(s)
Maximum serving Sizes:
9.34 Gram(s)
Servings per container
107
UPC/BARCODE
039442052087
IngredientAmount% DV
Calories0 Calorie(s)--
Total Carbohydrates0 Gram(s)--
Saturated Fat0 Gram(s)--
Total Fat0 Gram(s)--
Glutamine2.75 Gram(s)--
Leucine2.5 Gram(s)--
Isoleucine1.25 Gram(s)--
Valine1.25 Gram(s)--

Other ingredients: Citric Acid, natural and artificial Orange flavor, Aspartame, Annatto

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Plant #3001104580

Made proudly in the U.S.A.

EAC

WHO WE ARE Universal Nutrition has been providing cutting edge and staple nutritional supplements to bodybuilders and hard training athletes the world over since 1977. As time passes, certain ideals never go out of style. Honesty. Integrity. Respect. These are the values we uphold and are the bedrock upon which we built our business.

Furthermore, recent studies have shown that the BCAA/glutamine stack could increase strength and positively influence body composition. While taking this powerful stack in addition to a calorie-restricted diet, individuals gained lean mass while dramatically decreasing body fat. Whether you're dieting to make weight or are trying to maintain (or even increase) lean mass, studies prove that BCAA/glutamine stack is a potent amino acid combination. HOW WE BACK IT UP What is on the label is in the bottle and what is in the bottle will help you reach your goals. We believe it and proudly stand behind every product we manufacture. Our word is our bond.

Premium quality anti-catabolic Amino complex ~ Maximum nitrogen retention support ~ Recovery

Precautions

Made in a GMP facility on equipment that processes milk, soy, egg, peanuts, tree nuts, fish, shellfish, and wheat.

Ingredient Notes: Phenylketonurics: contains phenylalanine.

Warning: Keep out of reach of children.

Before beginning any program, consult your health care practitioner.

Formula

Ingredient Notes: Phenylketonurics: contains phenylalanine.

Suggested/Recommended/Usage/Directions

Dosage: For its potential anti-catabolic benefits during intense training or when dieting, take 2 servings per day, with one serving immediately following exercise. For optimum results, take this product in conjunction with your favorite post-training protein/carb shake.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

2015 Universal Nutrition

WHAT IT IS BCAA Stack can actually help you increase strength, boost performance, stay energized during dieting, and increase lean mass gains and body fat loss. Studies have shown that the formula in BCAA Stack can increase nitrogen retention, which in turn helps your body accumulate lean mass.

FDA Statement of Identity

Dietary Supplement

General

F0015-G-33256

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

BCAA Stack Orange Splash by Universal label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

BCAA Stack Orange Splash label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in BCAA Stack Orange Splash by Universal

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size9.34 Gram(s) Dosage formPowder Servings per container107 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glutamine

Interacts with
50 drugs
2.75 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

Glutamine monograph & interactions

Leucine

2.5 Gram(s) per serving

Isoleucine

1.25 Gram(s) per serving

Valine

1.25 Gram(s) per serving

Other (inactive) ingredients: Citric Acid, Natural and artificial Orange flavor, Aspartame, Annatto. These complete the product’s ingredient list but are not active constituents.

Interaction report

BCAA Stack Orange Splash by Universal Drug Interactions

Want to check YOUR meds against BCAA Stack Orange Splash?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

Glutamine 50

Individual Drug Interactions

The ingredients in BCAA Stack Orange Splash interact with 50 drugs. Click any drug to see the details.

1 of the 4 ingredients in BCAA Stack Orange Splash interact with drugs. Each result below shows which ingredient is responsible. Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in BCAA Stack Orange Splash with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for BCAA Stack Orange Splash, from the product label.

Universal

See all Universal products
Name
Universal Nutrition
City
New Brunswick
State
New Jersey
ZipCode
08901
Phone Number
800-872-0101
Web Address
www.UniversalUSA.com
Pharmacist Counseling Corner

BCAA Stack Orange Splash by Universal: Common Questions

Does BCAA Stack Orange Splash by Universal interact with any medications?
Yes. Based on its ingredients, BCAA Stack Orange Splash has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BCAA Stack Orange Splash contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is glutamine safe during pregnancy and while breastfeeding?
Glutamine is rated likely safe in both pregnancy and lactation. However, leucine, isoleucine, and valine don't have safety data on file for pregnancy and breastfeeding, so talk with your doctor before using this product if you're pregnant or nursing to make sure it's right for you.
What are the most common side effects I might notice?
Gastrointestinal upset is the most common issue — belching, bloating, constipation, diarrhea, flatulence, and nausea. Headache, dizziness, and muscle pain have also been reported. These tend to happen more at higher doses and usually resolve if you lower the amount.
Does this product actually work for muscle recovery?
We have effectiveness data for glutamine — it's effective for sickle cell disease and possibly effective for postoperative recovery and recovery from critical illness. We don't hold evidence on the branched-chain amino acids themselves, so we can't speak to their individual role in this product.
Can I take this if I have kidney or liver problems?
Glutamine should only be used under medical supervision if you have kidney or liver disease. Talk with your doctor before starting this supplement.
Is there a risk of mania or mood changes?
Mania and hypomania have been reported rarely — only in 2 patients with bipolar disorder taking glutamine at 4 grams daily. If you have bipolar disorder or a history of mood swings, mention this supplement to your doctor before taking it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if BCAA Stack Orange Splash is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BCAA Stack Orange Splash label
Go deeper

The Full Monographs Behind BCAA Stack Orange Splash’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

BCAA Stack Orange Splash's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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