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Dietary supplement

Bio-Pro Maitake Ingredients & Drug Interactions

by Nature's Answer

Bio-Pro Maitake label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bio-Pro Maitake against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bio-Pro Maitake is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Maitake. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bio-Pro Maitake by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Bio-Pro Maitake by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bio-Pro Maitake by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Bio-Pro Maitake contains one active ingredient: maitake mushroom, delivered as a liquid extract. Maitake, also called Grifola frondosa, is a medicinal fungus traditionally used in Asian medicine and studied for immune and metabolic support.

The supplement also includes vegetable glycerin and purified water as inactive ingredients to preserve and deliver the extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune support.
  • We looked for evidence on: Chemotherapy-induced leukopenia, HIV/AIDS, immune function, infection resistance, white blood cell support.
  • The closest evidence on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for HIV/AIDS (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced leukopenia.

The evidence we hold does not establish that maitake works for the conditions it's marketed for. Our data lists six uses — allergic rhinitis (hay fever), chemotherapy-induced anemia, laryngeal cancer, and chemotherapy-induced diarrhea — but all of them carry a rating of insufficient reliable evidence to rate.

That means the studies done so far aren't robust enough to confirm whether maitake delivers a real benefit for these purposes. If you're considering it for a specific condition, talk it over with your doctor.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake mushroom is generally well tolerated when taken by mouth, though some trial participants reported gastrointestinal side effects. In clinical research, a small number experienced diarrhea, nausea, or stomach pain (epigastric pain); one person withdrew from a study due to diarrhea, and another developed a rash and itching that cleared on its own.

The data advises against concentrated maitake supplements during pregnancy and breastfeeding due to insufficient safety information. As a food, maitake is considered safe, but supplement-form safety hasn't been fully studied.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check it with your doctor or pharmacist if you take warfarin (Coumadin) or any blood thinner — maitake may increase their effect and raise bleeding risk. Also flag it if you're on blood pressure medications or diabetes drugs, since maitake can lower blood pressure and blood sugar and might intensify their effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Maitake mushroom supplement might interest someone exploring traditional immune support, but the evidence we hold doesn't confirm it works for any specific condition. If you take blood thinners, blood pressure medications, or diabetes drugs, you'll need to check with your doctor or pharmacist before starting — the interactions are real and documented.

Anyone who's pregnant, breastfeeding, or taking prescription medications should confirm it's appropriate for them first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bio-Pro Maitake, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000007514
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 264081
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bio-Pro Maitake by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Drop(s)
Maximum serving Sizes:
6 Drop(s)
Servings per container
280
UPC/BARCODE
083000007514
IngredientAmount% DV
Maitake30 mg--

Other ingredients: Vegetable Glycerin, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Gluten Free

Highest Concentration Standardized Fluid Extract Professional Strength Immune Support

Alcohol-Free

Our alcohol-free extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

Seals/Symbols

K Parve (Kosher)

Bio-Chelated Cold extraction process

Formula

K Parve (Kosher)

15 mg Proteoglucan per serving

FDA Statement of Identity

Herbal Supplement

Brand IP Statement(s)

Nature's Answer Since 1972

Discover Nature's Answer

Copyright 2020 Nature's Answer

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take six (6) drops three (3) times a day in a small amount of water. Do not exceed maximum recommended daily serving of 18 drops per day. Shake Well.

Precautions

Do not exceed maximum recommended daily serving of 18 drops per day.

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bio-Pro Maitake by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bio-Pro Maitake label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bio-Pro Maitake by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size6 Drop(s) Dosage formLiquid Servings per container280 Amounts shown are per serving.

Maitake

Interacts with
260 drugs
30 mg per serving Form: Bio-Proteoglucan-NK Mushroom Extract, Proteoglucan

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bio-Pro Maitake by Nature's Answer Drug Interactions

Want to check YOUR meds against Bio-Pro Maitake?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

Maitake 260

Individual Drug Interactions

The ingredients in Bio-Pro Maitake interact with 260 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bio-Pro Maitake interact with drugs. Each result below shows which ingredient is responsible. Maitake

Each ingredient & the kinds of drugs it affects

For each ingredient in Bio-Pro Maitake with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Maitake3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bio-Pro Maitake, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Bio-Pro Maitake by Nature's Answer: Common Questions

Does Bio-Pro Maitake by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Bio-Pro Maitake has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bio-Pro Maitake contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will maitake help my diabetes?
The evidence we hold isn't strong enough to say. Our data shows that clinical research found maitake polysaccharide can lower blood glucose in type 2 diabetes patients, but we don't have a reliable rating for whether it's an effective treatment — the studies done so far aren't robust enough to confirm it works. Talk to your doctor about whether it might fit into your diabetes care.
What side effects should I watch for?
Most people tolerate maitake well, but gastrointestinal effects are the main ones to know about. In clinical trials, a small number of participants reported diarrhea, nausea, or stomach pain; one person's diarrhea was strong enough to drop out of the study. A single case of rash and itching was also reported and resolved without treatment.
Is it safe to take while pregnant or breastfeeding?
No — the safety data advises against concentrated maitake supplements during pregnancy and breastfeeding. There isn't enough information yet to know if it's safe in these situations, so talk with your doctor or pharmacist for personalized advice.
How is this liquid extract made?
Bio-Pro Maitake is a liquid extract of maitake mushroom preserved in vegetable glycerin and purified water. The extract concentrates the active compounds from the mushroom into a form you can take by mouth.
Can I use this if I take blood thinners?
Not without checking first. There's limited evidence that maitake may increase warfarin's (Coumadin's) blood-thinning effects — one patient's blood thickness level jumped after a week of maitake. Talk with your doctor or pharmacist before starting it if you're on any blood thinner.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bio-Pro Maitake label
Go deeper

The Full Monographs Behind Bio-Pro Maitake’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

Bio-Pro Maitake's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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