Bitter Melon Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Bitter Melon Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bitter Melon Extract is a dietary supplement by Earthborn Elements with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 282 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bitter Melon Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bitter Melon Extract by Earthborn Elements
Ask about any prescription or over-the-counter medication and we check it for interactions with Bitter Melon Extract by Earthborn Elements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Bitter Melon Extract by Earthborn Elements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: bitter melon extract, a concentrated form of the bitter melon fruit. The capsule itself is made with gelatin as an inactive ingredient.
Does it work?
Couldn't assess
The evidence we hold doesn't establish that bitter melon extract works for diabetes, constipation, liver disease, amenorrhea, athletic performance, or indigestion (dyspepsia) — the effectiveness data on file rates all of these as insufficient reliable evidence to rate. If you're considering it for one of these uses, talk with your pharmacist or doctor about what the current research really supports.
How safe is it?
Well-documented data
Bitter melon extract is generally well tolerated when taken by mouth. The most common side effects are gastrointestinal — heartburn, nausea, vomiting, diarrhea, constipation, flatulence, and abdominal discomfort occur in roughly 3 to 16 percent of people in studies.
Dizziness, headache, and fatigue have also been reported. Because it can lower blood sugar, it may cause dizziness or lightheadedness, especially if you're also on diabetes medications.
Rarely, serious effects like very low blood sugar (hypoglycemic coma) and seizures in children have been documented. One case report linked long-term use (600–1200 mg daily for several months) to kidney inflammation, which reversed after stopping the supplement.
The safety data advises against use in pregnancy because seeds and high doses may cause harmful effects to the uterus or elsewhere. There isn't enough reliable data to know whether it's safe while breastfeeding — talk with your doctor or pharmacist before use.
Meds to double-check
Moderate interaction found
Before you start, check with your pharmacist if you take antidiabetes drugs (blood sugar medications), pazopanib (a cancer medication), or any drugs that depend on a cellular pump called P-glycoprotein to move through your intestines — bitter melon may alter how your body handles these medications.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Bitter melon extract is something to consider only if you've talked with your pharmacist or doctor first — especially if you're on any diabetes medication or pazopanib. The evidence doesn't yet support its use for the conditions it's often marketed for.
If you do take it, watch for stomach upset and dizziness, and don't take it in pregnancy or while breastfeeding without professional guidance.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bitter Melon Extract, straight from the product label.
| Brand | Earthborn Elements |
|---|---|
| Net contents | 200 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 21, 2024 |
| DSLD ID | 319492 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bitter Melon Extract by Earthborn Elements, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: Take 2 capsules daily preferably with meals, or as directed by a physician.
Precautions
If you are pregnant, nursing, or taking medications, consult your healthcare professional before taking this or any dietary supplements.
For adults only.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease or health condition.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bitter Melon Extract by Earthborn Elements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bitter Melon Extract by Earthborn Elements
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Bitter Melon Extract
Interacts with282 drugs
Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...
Bitter Melon Extract monograph & interactionsOther (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.
Bitter Melon Extract by Earthborn Elements Drug Interactions
HelloPharmacist Interaction Report
Earthborn Elements Bitter Melon Extract does interact with medications — most notably with antidiabetes drugs (blood sugar medications) and a cancer drug called pazopanib.
The biggest concern is antidiabetes drugs: bitter melon can lower your blood glucose, and combining it with diabetes medications puts you at risk for low blood sugar (hypoglycemia). You'd need to monitor your blood glucose closely if you take both.
Read the full breakdown — every affected drug type, severity by severity
Bitter melon may also increase levels of P-glycoprotein substrates — a group of drugs that rely on a cellular pump to move them through your intestines. If that pump gets blocked, these drugs can build up in your body and potentially cause harm.
One case report also documented a patient on pazopanib (a kidney cancer medication) who developed acute pancreatitis (pancreas inflammation) four days after starting bitter melon juice at 100–150 mL daily, though a direct cause isn't certain.
Additionally, if you're on any other medications, run them through the medication checker on this page. Altogether, these interactions span 275 individual medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bitter Melon Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bitter Melon Extract interact with 282 drugs. Click any drug to see the details.
1 of the 1 ingredient in Bitter Melon Extract interact with drugs. Each result below shows which ingredient is responsible. Bitter Melon Extract
BetrixabanBevyxxa
How Betrixaban interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Betrixaban interactionBictegravir, Emtricitabine, Tenofovir AlafenamideBiktarvy
How Bictegravir, Emtricitabine, Tenofovir Alafenamide interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Bictegravir, Emtricitabine, Tenofovir Alafenamide interactionBoceprevirVictrelis
How Boceprevir interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Boceprevir interactionCanagliflozinInvokana
How Canagliflozin interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Canagliflozin, Metformin Hydrochloride interactionCeliprololCelicard
How Celiprolol interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Celiprolol interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Chlorpropamide interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Chlortetracycline interactionCimetidineCimetidine Injection, Tagamet, Tagamet HB
How Cimetidine interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Cimetidine interactionCisapridePropulsid
How Cisapride interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Cisapride interactionClobetasolClobex, Temovate
How Clobetasol interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Clobetasol interactionCobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide FumarateGenvoya
How Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interactionColchicineColchicine, Colcrys, Colsalide Improved, Gloperba, Lodoco, Mitigare
How Colchicine interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Colchicine interactionColchicine, ProbenecidColBenemid
How Colchicine, Probenecid interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Colchicine, Probenecid interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Conjugated Estrogens, Methyltestosterone interactionCortisone AcetateCortisone Tablets, Cortone
How Cortisone Acetate interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Cortisone Acetate interactionCrizotinibXalkori
How Crizotinib interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Crizotinib interactionCyclosporineCequa, Ciclosporine, Gengraf, Neoral, Sandimmune, Verkazia +1 more
How Cyclosporine interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Cyclosporine interactionCyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Cyproterone Acetate, Ethinyl Estradiol interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDarolutamideNubeqa
How Darolutamide interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Darolutamide interactionDarunavir, Cobicistat, Emtricitabine, Tenofovir AlafenamideSymtuza
How Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interactionDarunavir, RitonavirDarunavir, Ritonavir
How Darunavir, Ritonavir interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Darunavir, Ritonavir interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bitter Melon Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bitter Melon Extract
Antidiabetes Drugs
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
P-Glycoprotein Substrates
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.
Pazopanib (Votrient)
Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.
Brand information
Manufacturer and brand details for Bitter Melon Extract, from the product label.
Earthborn Elements
See all Earthborn Elements products- Name
- Earthborn Elements
- Street Address
- 9450 SW Gemini Dr #49936
- City
- Beaverton
- State
- Oregon
- ZipCode
- 97008
- Web Address
- Earthbornelements.com
Bitter Melon Extract by Earthborn Elements: Common Questions
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How can one product interact with so many drugs?
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Does this actually work for diabetes?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bitter Melon Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bitter Melon Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Bitter Melon Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bitter Melon 18 references
- Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
- Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
- Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
- Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
- Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
- Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
- Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
- Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
- Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
- Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
- Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
- Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
- Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
- Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
- Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
- Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
- Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
- Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC