Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Bone Collagenizer 50 Plus Ingredients & Drug Interactions

by BioSil

Bone Collagenizer 50 Plus label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bone Collagenizer 50 Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bone Collagenizer 50 Plus is a dietary supplement by BioSil with 3 active ingredients. Its ingredients are commonly taken for polycystic ovary syndrome (pcos), anxiety and panic, depression and mood.Based on those ingredients, 102 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Inositol, Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Bone Collagenizer 50 Plus by BioSil

Ask about any prescription or over-the-counter medication and we check it for interactions with Bone Collagenizer 50 Plus by BioSil — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Bone Collagenizer 50 Plus by BioSil

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Bone Collagenizer 50 Plus has three active ingredients. Inositol is a natural compound that acts on cell signaling and may support metabolic health.

Choline is an essential nutrient involved in brain function and cell membrane structure. Silicon is a mineral that supports bone and connective tissue strength.

The capsules also contain microcrystalline cellulose, purified water, and a capsule shell as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Bone health and collagen support.
  • We looked for evidence on: Osteoporosis, Bone density, Connective tissue integrity, Collagen synthesis.
  • The strongest evidence on file: Silicon is rated "Possibly Effective" for Osteoporosis (Natural Medicines).

For inositol, the evidence suggests it may help with polycystic ovary syndrome (PCOS), metabolic syndrome, and preterm labor, though the data is not conclusive. For other uses — anxiety, diabetic nerve pain, and depression — the evidence doesn't support its use.

Choline has insufficient evidence for most conditions we hold data on, including age-related cognitive decline and Alzheimer's disease. Silicon shows possibly effective evidence for osteoporosis, but evidence is insufficient for hair loss and dental issues.

Overall, this product's effectiveness depends on which condition you're targeting — some uses have preliminary support, others do not.

The evidence, ingredient by ingredient Inositol Choline Silicon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Inositol is generally well tolerated; the most common side effects are mild digestive issues like diarrhea, gas, and nausea. Choline is safe in food amounts but high-dose supplements can cause side effects — the daily upper limit is 3.5 grams, and doses of 9 grams or more may cause diarrhea, nausea, sweating, and a fishy body odor.

Silicon from food and most supplements is well tolerated; serious side effects are mainly from inhaled occupational dust, not oral supplements. For pregnancy, inositol is possibly safe but should be used only under medical supervision; choline is likely safe and is actually important during pregnancy, though supplement doses should be guided by your doctor.

For breastfeeding, choline is likely safe and needs are actually higher while nursing, but use supplements only under professional guidance; inositol and silicon safety data are not on file during breastfeeding, so talk with your doctor or pharmacist.

Side effects, ingredient by ingredient Inositol Choline Silicon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Inositol, Choline.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 102 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take diabetes medications (insulin, metformin, sulfonylureas, or others), check with your pharmacist before using this product — inositol may lower your blood sugar further. If you take atropine, note that choline in this product may theoretically reduce its effects.

Run your complete medication list through the checker on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bone Collagenizer 50 Plus may be worth considering if you're looking to support bone health or manage PCOS or metabolic syndrome, but the evidence for those uses is preliminary. If you take diabetes medications or atropine, you'll want to check this product with your pharmacist first — the inositol in it can lower blood sugar.

Pregnant or breastfeeding? Talk with your doctor before starting, since the safety picture is mixed across ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bone Collagenizer 50 Plus, straight from the product label.

Brand BioSil
Barcode (UPC) 5425010391552
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 21, 2017
DSLD ID 77034
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Seniors/Mature (>50 Years) - Women ONLY, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bone Collagenizer 50 Plus by BioSil, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
5425010391552
IngredientAmount% DV
Inositol50 mg--
Choline120 mg22%
Silicon6 mg--

Other ingredients: Microcrystalline Cellulose, purified Water, Capsule Shell

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take 2 capsules, once daily, with or without food. For optimum results, take with your daily calcium supplement or a calcium rich food source.

Precautions

Consult your health professional before use if you are pregnant, breastfeeding or trying to conceive, or if you are taking medication, have a medical condition or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal if broken.

Formulation

Does not contain: Gluten, wheat, soy, yeast, dairy, sugar, starch, egg, fish, shellfish, peanuts or tree nuts, animal products, GMOs or artificial colors, preservatives or sweeteners.

V Vegan Vegetarian

Suitable for vegetarians/vegans.

Seals/Symbols

V Vegan Vegetarian

isura Non-GMO - Mass spec Documentation - Lab tested

Brand IP Statement(s)

ch-OSA, the ch-OSA logo, the Vegetarian logo, collangenizer and BioSil are all registered trademarks of Bio Minerals NV. The clinical facts is a trademark of Bio Minerals NV. ch-OSA is protected by US patents 5,922,360, 7,968,528 and 8,771,757

U.S. Patents #5922360, #7968528 and #8771757

2016 Bio Minerals NV

Clinical facts Choline-stabilized orthosilicic acid (ch-OSA) Clinically proven dosage Ch-OSA Clinically proven for bone 2 capsules 1 x daily Increases bone collagen formation Increases BMD (at the hip) above calcium and vitamin D alone Use in conjunction with 1000 mg of calcium and 20 mcg (800 IU) of vitamin D ch-OSA has been tested in rigorous double-blind placebo controlled clinical trial for both efficacy and safety. The results are published in peer reviewed medical journals (see insert for details).

Results of double-blind, randomized, placebo-controlled clinical trials, with women who added Bone Collagenizer to their daily supplements of 1000 mg of calcium and 800 mcg IU of vitamin D.

General Statements

Measured at the hip

Clinically proven

Increases bone collagen formation Increases calcium binding sites Promotes bone pliability Increases bone mineral density (BMD) Boosts the effectiveness of dietary and supplement calcium Helps maintain positive osteoblast balance

Made in Belgium

The science of healthy bones at 50 plus The National Institutes of Health reports that it takes both calcium and collagen to build strong healthy bones. Collagen serves as the "binding sites" for calcium and gives bone the pliability it needs to withstand physical stress.

Insufficient bone collagen Insufficient calcium "binding sets," low BMD brittle bone and "holes" in bone (osteoporosis) Optimal bone collagen Optimal calcium "binding sets," optimum BMD, strong, pliable with ability to bend-not-break

Now in new small caps

Product facts

Clinical trial results

Increase in bone collagen formulation % change in serum P1NP Level (ug/l) 33 35 37 39 41 43 Calcium & vitamin D ch-OSA calcium & vitamin D 36.49 42.04 15.0% increase in P1NP first 12 months

Increase in BMD at hip Change in bone mineral density -1.00 -50 0 .50 1.00 Calcium & vitamin D -1.22 ch-OSA calcium & vitamin D +.78 2.0% improvement in BMD at hip first 12 months

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Specially formulated for women 50 plus

ch-OSA Original formula

The ch-OSA in Collagenizer 50 Plus generates collagen. The inositol helps maintain "osteo-balance."

Osteo-balance is vital for women over 50 as bone-destroying osteoclasts begin to outpace bone-building osteoblasts.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool dry place.

General

R1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bone Collagenizer 50 Plus by BioSil label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bone Collagenizer 50 Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bone Collagenizer 50 Plus by BioSil

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Inositol

Interacts with
86 drugs
50 mg per serving

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, m...

Inositol monograph & interactions

Choline

Interacts with
16 drugs
120 mg per serving Form: ch-OSA

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Silicon

No known
interactions
6 mg per serving Form: Choline-stabilized Orthosilicic Acid

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for h...

Silicon monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Purified Water, Capsule Shell. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bone Collagenizer 50 Plus by BioSil Drug Interactions

Want to check YOUR meds against Bone Collagenizer 50 Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
102Drugs
86 Moderate 16 Minor

Ingredients driving the most interactions

Inositol 86
Choline 16

Individual Drug Interactions

The ingredients in Bone Collagenizer 50 Plus interact with 102 drugs. Click any drug to see the details.

2 of the 3 ingredients in Bone Collagenizer 50 Plus interact with drugs. Each result below shows which ingredient is responsible. Inositol Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Bone Collagenizer 50 Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Inositol1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that inositol lowers blood glucose levels and glycated hemoglobin (HbA1c) levels in patients with diabetes.

Likelihood Possible Evidence A
Inositol full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bone Collagenizer 50 Plus, from the product label.

BioSil

See all BioSil products
Name
Bio Minerals NV
State
Destelbergen
Pharmacist Counseling Corner

Bone Collagenizer 50 Plus by BioSil: Common Questions

Does Bone Collagenizer 50 Plus by BioSil interact with any medications?
Yes. Based on its ingredients, Bone Collagenizer 50 Plus has a known interaction with 102 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bone Collagenizer 50 Plus contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does inositol really help with PCOS?
The evidence suggests it possibly helps, but it's not conclusive. It may be worth trying under your doctor's care if you have PCOS, especially since the research shows it can affect blood sugar and certain hormone markers — but it's not a proven cure.
Will this give me side effects?
Most people tolerate it well. Mild digestive side effects like diarrhea, gas, and nausea are the most common, especially from inositol. Choline at the doses in supplements can sometimes cause a fishy body odor. If you take very high doses of choline (9+ grams daily), you might get more serious symptoms like sweating or vomiting — but a typical supplement is well below that.
Is this safe if I'm pregnant?
Inositol is possibly safe in pregnancy but should only be used under medical supervision since full safety data isn't established. Choline is likely safe and is actually important during pregnancy — but use only the dose your doctor recommends. Silicon safety data isn't on file for pregnancy, so ask your doctor before starting.
What does silicon do?
Silicon is a mineral that supports bone and connective tissue strength. The evidence suggests it may help with osteoporosis, but the data for other uses like hair loss isn't clear yet.
Can I take this with my diabetes medication?
You need to check with your pharmacist first. Inositol in this product can lower blood sugar, so combined with your diabetes drug it might increase your risk of low blood sugar (hypoglycemia). Your pharmacist can help you figure out if it's safe or if you need dose adjustments.
Does this product have fillers?
Yes — the capsule contains microcrystalline cellulose (a binder), purified water, and a capsule shell. Those are inactive ingredients and don't have a therapeutic role, but they're part of how the capsule is made.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bone Collagenizer 50 Plus is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bone Collagenizer 50 Plus label
Go deeper

The Full Monographs Behind Bone Collagenizer 50 Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Inositol

Interacts with 86 drugs

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, mood, and metabolic concerns. The stronge...

Read the full Inositol monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Silicon

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for hair, skin, nail, and bone health. Some s...

Read the full Silicon monograph →
Sources

Sources & How We Checked

Bone Collagenizer 50 Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 47 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Inositol 14 references
  1. Palatnik A, Frolov K, Fux M, Benjamin J. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J Clin Psychopharmacol 2001;21:335-9.. PubMed
  2. Allan SJ, Kavanagh GM, Herd RM, Savin JA. The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial. Br J Dermatol 2004;150:966-9. PubMed
  3. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  4. Kamenov Z, Kolarov G, Gateva A, Carlomagno G, Genazzani AD. Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance. Gynecol Endocrinol 2015;31(2):131-5. PubMed
  5. Matarrelli B, Vitacolonna E, D'Angelo M, et al. Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trial. J Matern Fetal Neonatal Med 2013;26(1 PubMed
  6. Mukai T, Kishi T, Matsuda Y, Iwata N. A meta-analysis of inositol for depression and anxiety disorders. Hum Psychopharmacol 2014;29(1):55-63. PubMed
  7. Farren M, Daly N, McKeating A, Kinsley B, Turner MJ, Daly S. The Prevention of Gestational Diabetes Mellitus With Antenatal Oral Inositol Supplementation: A Randomized Controlled Trial. Diabetes Care. 2017;40(6):759-63. PubMed
  8. Zheng X, Liu Z, Zhang Y, et al. Relationship Between Myo-Inositol Supplementary and Gestational Diabetes Mellitus: A Meta-Analysis. Medicine (Baltimore). 2015;94(42):e1604. PubMed
  9. Crawford TJ, Crowther CA, Alsweiler J, Brown J. Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes. Cochrane Database Syst Rev. 2015;(12):CD011507. PubMed
  10. Maurizi AR, Menduni M, Del Toro R, et al. A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. Acta Diabetol. 2017;54(4):361-65. PubMed
  11. Leppink EW, Redden SA, Grant JE. A double-blind, placebo-controlled study of inositol in trichotillomania. Int Clin Psychopharmacol. 2017;32(2):107-14. PubMed
  12. Lam S, Mandrekar SJ, Gesthalter Y. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer Prev Res (Phila). 2016;9(12):906-14.
  13. Wozniak J, Faraone SV, Chan J, et al. A randomized clinical trial of high eicosapentaenoic acid omega-3 fatty acids and inositol as monotherapy and in combination in the treatment of pediatric bipolar spectrum disorders: a pilot study. J Clin Psychiatry. PubMed
  14. Vitale SG, Corrado F, Caruso S, et al. Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes - a randomized and open-label, placebo-

See these in context on the Inositol monograph →

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Silicon 19 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Jugdaohsingh R, Anderson SH, Tucker KL, et al. Dietary silicon intake and absorption. Am J Clin Nutr 2002;75:887-93. PubMed
  3. Ichiyanagi O, Sasagawa I, Adachi Y, et al. Silica urolithiasis without magnesium trisilicate intake. Urol Int 1998;61:39-42. PubMed
  4. Levison DA, Crocker PR, Banim S, Wallace DM. Silica stones in the urinary bladder. Lancet 1982;1:704-5. PubMed
  5. Lee MH, Lee YH, Hsu TH, et al. Silica stone--development due to long time oral trisilicate intake. Scand J Urol Nephrol 1993;27:267-9. PubMed
  6. Cruz Guerra, N. A., Gomez Garcia, M. A., Lovaco, Castellano F., Saez Garrido, J. C., Garcia, Cuerpo E., and Escudero, Barrilero A. [Silica urolithiasis: report of a new case]. Actas Urol.Esp 2000;24(2):202-204.
  7. Merget, R., Bauer, T., Kupper, H. U., Philippou, S., Bauer, H. D., Breitstadt, R., and Bruening, T. Health hazards due to the inhalation of amorphous silica. Arch Toxicol. 2002;75(11-12):625-634. PubMed
  8. Khuder, S. A., Peshimam, A. Z., and Agraharam, S. Environmental risk factors for rheumatoid arthritis. Rev Environ Health 2002;17(4):307-315. PubMed
  9. McLaughlin, J. K., Chow, W. H., and Levy, L. S. Amorphous silica: a review of health effects from inhalation exposure with particular reference to cancer. J Toxicol.Environ Health 4-25-1997;50(6):553-566. DOI
  10. Pelucchi, C., Pira, E., Piolatto, G., Coggiola, M., Carta, P., and La, Vecchia C. Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996-2005. Ann.Oncol. 2006;17(7):1039-1050. PubMed
  11. Gillissen, A., Gessner, C., Hammerschmidt, S., Hoheisel, G., and Wirtz, H. [Health significance of inhaled particles]. Dtsch.Med Wochenschr. 3-24-2006;131(12):639-644.
  12. Hu, J. F., Qu, H., and Wang, J. Z. [Meta analysis for relationship between exposure of free silicon dioxide and lung tumor]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2006;24(7):415-417.
  13. Jugdaohsingh, R. Silicon and bone health. J Nutr Health Aging 2007;11(2):99-110.
  14. Lacasse, Y., Martin, S., Gagne, D., and Lakhal, L. Dose-response meta-analysis of silica and lung cancer. Cancer Causes Control 2009;20(6):925-933. PubMed
  15. McCormic, Z. D., Khuder, S. S., Aryal, B. K., Ames, A. L., and Khuder, S. A. Occupational silica exposure as a risk factor for scleroderma: a meta-analysis. Int Arch Occup.Environ Health 2010;83(7):763-769. PubMed
  16. Haddad, F. S. and Kouyoumdjian, A. Silica stones in humans. Urol.Int 1986;41(1):70-76. PubMed
  17. Tervaert, J. W., Stegeman, C. A., and Kallenberg, C. G. Silicon exposure and vasculitis. Curr Opin.Rheumatol 1998;10(1):12-17. PubMed
  18. Steenland, K. and Stayner, L. Silica, asbestos, man-made mineral fibers, and cancer. Cancer Causes Control 1997;8(3):491-503. PubMed
  19. Boqué N, Valls RM, Pedret A, Puiggrós F, Arola L, Solà R. Relative absorption of silicon from different formulations of dietary supplements: a pilot randomized, double-blind, crossover post-prandial study. Sci Rep 2021;11(1):16479. PubMed

See these in context on the Silicon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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