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Dietary supplement

Brocco Advanced Ingredients & Drug Interactions

by PureFormulas

Brocco Advanced label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Brocco Advanced against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Brocco Advanced is a dietary supplement by PureFormulas with 1 active ingredient. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BroccoRaphanin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Brocco Advanced by PureFormulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Brocco Advanced by PureFormulas — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Brocco Advanced by PureFormulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Brocco Advanced contains one active ingredient: BroccoRaphanin, a concentrated extract from broccoli. The capsule also holds two inactive ingredients — microcrystalline cellulose and vegetable stearate — which serve as filler and binder to form the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Broccoli's overall clinical evidence instead.

Moderate

Some clinical evidence supports Broccoli for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Colorectal cancer — rated "Possibly Effective" (Natural Medicines).

The evidence for broccoli extract in Brocco Advanced is mixed. It's rated possibly effective for colorectal cancer.

For bladder cancer, breast cancer, fibromyalgia, and gastric cancer, the evidence isn't established in our data — there's either too little research or it hasn't been reliable enough to rate.

The evidence, ingredient by ingredient Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as a food is generally well tolerated in normal amounts, but concentrated supplements like this one are less studied. The safety data advises caution with concentrated extracts unless your doctor approves.

Some people have reported loose stools, diarrhea, belly pain, and cramping after taking broccoli seed or sprout extracts, especially at higher doses. Allergic reactions, including contact dermatitis, have been reported with topical broccoli.

For pregnancy and breastfeeding, broccoli is rated likely safe based on the data we hold.

Side effects, ingredient by ingredient Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Brocco Advanced, check with your doctor or pharmacist if you take any medications broken down by CYP2A6 or CYP1A2 enzymes — broccoli can lower their levels and reduce how well they work. Both interactions carry Moderate severity.

Use the medication search tool on this page to enter your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Brocco Advanced may be worth considering if you're interested in broccoli's possible role in colorectal cancer support and your doctor has approved it. However, the concentrated extract here isn't as well studied as broccoli food, and it can speed up how your liver breaks down many medications — so it's essential to check your exact drugs with your pharmacist or doctor before starting.

If you take CYP1A2 or CYP2A6 substrates, have a detailed conversation with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Brocco Advanced, straight from the product label.

Brand PureFormulas
Barcode (UPC) PUF1098
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2019
DSLD ID 205420
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Brocco Advanced by PureFormulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
PUF1098
IngredientAmount% DV
BroccoRaphanin500 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: As a dietary supplement, take one capsule per day with a meal, or as directed by your health care practitioner.

Brand IP Statement(s)

BroccoRaphanin is a registered trademark of CS Health.

General Statements

Notice: Color, size or shape may appear different between lots.

Live life pure.

Detox support

Formulation

Does not contain gluten.

Non-GMO

Storage

Store at room temperature.

Precautions

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Non-GMO

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Brocco Advanced by PureFormulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Brocco Advanced label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Brocco Advanced by PureFormulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

BroccoRaphanin

Interacts with
187 drugs
500 mg per serving Form: Sulforaphane Glucosinolate

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

BroccoRaphanin monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Brocco Advanced by PureFormulas Drug Interactions

Want to check YOUR meds against Brocco Advanced?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

BroccoRaphanin 187

Individual Drug Interactions

The ingredients in Brocco Advanced interact with 187 drugs. Click any drug to see the details.

1 of the 1 ingredient in Brocco Advanced interact with drugs. Each result below shows which ingredient is responsible. BroccoRaphanin

Each ingredient & the kinds of drugs it affects

For each ingredient in Brocco Advanced with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

BroccoRaphanin2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
BroccoRaphanin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Brocco Advanced, from the product label.

PureFormulas

See all PureFormulas products
Name
PureFormulas
Street Address
11800 NW 102nd Road, Suite 2
City
Miami
State
FL
ZipCode
33178
Web Address
www.pureformulas.com
Pharmacist Counseling Corner

Brocco Advanced by PureFormulas: Common Questions

Does Brocco Advanced by PureFormulas interact with any medications?
Yes. Based on its ingredients, Brocco Advanced has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Brocco Advanced contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Brocco Advanced if I'm pregnant or breastfeeding?
Broccoli is rated likely safe during pregnancy and breastfeeding based on the data we hold. That said, this is a concentrated supplement, not whole food, and concentrated extracts are less studied. Talk with your doctor or midwife before starting to make sure it's right for you.
What side effects might I experience?
Some people report loose stools, diarrhea, belly pain, and cramping after taking broccoli extracts, especially at higher doses. Allergic reactions are rare but possible. If you notice any of these, stop and let your pharmacist or doctor know.
Does Brocco Advanced actually work for cancer?
Broccoli extract is possibly effective for colorectal cancer, so there's some evidence there. For breast cancer, bladder cancer, and gastric cancer, the evidence in our data is too thin to rate — we don't know yet. Talk to your oncologist about whether it fits into your plan.
Why does broccoli affect so many medications?
Broccoli contains glucosinolates, which rev up your liver's CYP1A2 and CYP2A6 enzymes — the machinery that breaks down many drugs. When those enzymes work faster, drug levels drop and the medicine may not work as well. That's why checking with your pharmacist is critical.
Is this supplement safe because it's from broccoli?
Broccoli food is safe for most people in normal amounts, but this concentrated extract is different — the safety data for concentrated supplements is less established. Your doctor or pharmacist can help you weigh whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Brocco Advanced label
Go deeper

The Full Monographs Behind Brocco Advanced’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

Brocco Advanced's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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