CCF Tea Joyful Heart Ingredients & Drug Interactions
What is this page for?
First and foremost: checking CCF Tea Joyful Heart against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
CCF Tea Joyful Heart is a dietary supplement by Banyan Botanicals with 9 active ingredients. Its ingredients are commonly taken for stress and anxiety, blood sugar support, respiratory complaints.Based on those ingredients, 1,456 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Chamomile, Fennel, Coriander. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against CCF Tea Joyful Heart by Banyan Botanicals
Ask about any prescription or over-the-counter medication and we check it for interactions with CCF Tea Joyful Heart by Banyan Botanicals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of CCF Tea Joyful Heart by Banyan Botanicals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
CCF Tea Joyful Heart is a 9-ingredient herbal blend designed to support calm and emotional balance. The active ingredients are holy basil, chamomile, hibiscus, fennel, orange, spearmint, coriander, rose, and cumin — each chosen for its traditional role in Ayurvedic wellness.
The product contains no inactive fillers or binding agents; the listed form is powder, ready to steep as tea.
Does it work?
Not established
The evidence for the individual herbs in this blend is limited. Holy basil, chamomile, fennel, spearmint, coriander, and orange each show insufficient reliable evidence to establish whether they work for anxiety, cognitive function, or the other conditions they're traditionally used for.
Fennel is possibly effective for period pain (dysmenorrhea), and that's the only effectiveness rating we hold for these ingredients. Because this is a multi-ingredient blend with proprietary proportions, we have no clinical data on the combination itself.
How safe is it?
Well-documented data
Holy basil, chamomile, fennel, spearmint, coriander, and cumin are generally well tolerated in food and tea amounts, but long-term safety data are limited for concentrated supplements. The most common side effects are mild — loose stools and nausea from holy basil, nausea or burning in the mouth from chamomile, and gastrointestinal discomfort from fennel or cumin.
Allergic reactions are possible: chamomile can trigger severe reactions in people sensitive to ragweed and related plants, and fennel, coriander, and cumin have each caused anaphylaxis in sensitive individuals (rare). Orange is safe in food amounts and likely safe in pregnancy and breastfeeding.
Holy basil is possibly unsafe in pregnancy and should be avoided while breastfeeding. Fennel, spearmint, and coriander are possibly unsafe in pregnancy at concentrated doses; spearmint and coriander lack sufficient data while breastfeeding.
Meds to double-check
Major interaction found
Check with your pharmacist before use if you take anticoagulants or antiplatelet drugs (blood thinners like warfarin), drugs that lower blood sugar (diabetes medications), drugs that make you drowsy (CNS depressants), medications absorbed by OATP transporters, cholesterol drugs (especially pravastatin), the antibiotic ciprofloxacin, birth control pills or hormone replacement therapy, or rifampin. No interactions are documented for hibiscus or rose.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
If you take blood thinners, diabetes medications, sedatives, or any prescription drugs — especially those absorbed through OATP transporters or metabolized by your liver — check your exact medications with the tool on this page before starting this tea. Those with ragweed allergies or a history of reactions to spices should be cautious.
Chat with your pharmacist or doctor about whether this blend fits your current medications and medical history.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 7 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about CCF Tea Joyful Heart, straight from the product label.
| Brand | Banyan Botanicals |
|---|---|
| Barcode (UPC) | 618192077825 |
| Net contents | 6 Ounce(s); 170 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Jan 24, 2024 |
| DSLD ID | 305608 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Organic |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for CCF Tea Joyful Heart by Banyan Botanicals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 0.5 Tablespoon(s) | -- |
| Holy Basil | 0 NP | -- |
| Chamomile | 0 NP | -- |
| Hibiscus | 0 NP | -- |
| Fennel | 0 NP | -- |
| Orange | 0 NP | -- |
| Spearmint | 0 NP | -- |
| Coriander | 0 NP | -- |
| Rose | 0 NP | -- |
| Cumin | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
CCF Tea Joyful Heart with Tulsi and Rose
Joyful Heart combines Ayurveda's famous spice blend of coriander, cumin, and fennel with herbs like tulsi, hibiscus, and rose to uplift the spirits and help foster a sense of peace. Sip this herbal blend throughout the day for increased harmony and joy. Also try it as a sun tea!
Formulation
Organic Ayurvedic Teas
Caffeine-free herbal blend
USDA Organic
Non GMO
Harmonizing blend Lifts the spirits and promotes peace
Sustainably Sourced Fairly traded
Certified Organic by: QAI
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
USDA Organic
Certified B Corporation
Suggested/Recommended/Usage/Directions
Suggested use: Combine 1/2 tablespoon Joyful Heart with 8 ounces hot water. Let steep for 5-7 minutes, strain, and serve! Joyful Heart can be made in larger batches at the ratio of 1/2 tablespoon per 1 cup of water. For a stronger brew, steep for 10 minutes.
Precautions
Not to be used during pregnancy. If you are nursing, taking medications, or have a medical condition, please consult with your health care practitioner prior to the use of this product.
General Statements
Banyan Botanicals was founded in 1996 with the mission to help people achieve and maintain optimal health and well-being. As a Ayurvedic lifestyle company, we specialize in products made from herbs that are organically grown, sustainably sourced, fairly traded, and made in the USA. We are proud to be a Certified B Corporation, joining the global movement to redefine success in business. Illuminate your path to well-being Get your free Ayurvedic profile at banyanbotanicals.com/illuminate
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
CCF Tea Joyful Heart by Banyan Botanicals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in CCF Tea Joyful Heart by Banyan Botanicals
These are the 9 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.5 Tablespoon(s) Dosage formPowder Servings per container70 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
CCF Tea Joyful Heart by Banyan Botanicals Drug Interactions
HelloPharmacist Interaction Report
CCF Tea Joyful Heart by Banyan Botanicals contains several herbs that interact with medications.
The most serious concern is orange, which can cause Major interactions affecting your absorption of certain drugs. Orange juice blocks a key transporter (OATP) that helps your body absorb some medications — you'll need to separate taking this tea from those drugs by at least 4 hours.
It also significantly increases levels of the cholesterol drug pravastatin and blocks absorption of the parasite drug ivermectin and the blood pressure drug celiprolol.
Read the full breakdown — every affected drug type, severity by severity
The other herbs (holy basil, chamomile, fennel, spearmint, coriander, and cumin) carry Moderate interactions. Holy basil may increase bleeding risk with blood thinners, raise low blood sugar (hypoglycemia) with diabetes medications, and boost sedation from pentobarbital.
Chamomile can add to the drowsy effects of sedatives, potentially raise levels of certain drugs your liver breaks down (those metabolized by CYP2D6, CYP2C9, or CYP3A4 enzymes), reduce birth control effectiveness, and boost the blood-thinning effects of warfarin. Fennel may increase bleeding risk with anticoagulants, reduce birth control and hormone therapy effectiveness, and lower levels of the antibiotic ciprofloxacin by half.
Spearmint and coriander may add sedative effects; coriander may also lower blood pressure or blood sugar. Cumin may increase bleeding risk and lower blood sugar.
We could not check hibiscus or rose — no interaction data are on file for them.
Altogether, these interactions span 1,457 individual medications. Use the medication checker on this page to see if any of your specific drugs are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against CCF Tea Joyful Heart?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in CCF Tea Joyful Heart interact with 1,456 drugs. Click any drug to see the details.
7 of the 9 ingredients in CCF Tea Joyful Heart interact with drugs. Each result below shows which ingredient is responsible. Chamomile Fennel Coriander Spearmint Orange Holy Basil Cumin
AtorvastatinAtorvaliq
How Atorvastatin interacts with CCF Tea Joyful Heart — through 4 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Atorvastatin interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Atorvastatin interactionFennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Atorvastatin interactionChamomileCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with CCF Tea Joyful Heart — through 4 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Atorvastatin Calcium interactionChamomileCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Atorvastatin Calcium interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Atorvastatin Calcium interactionFennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Atorvastatin Calcium interactionBosentanTracleer
How Bosentan interacts with CCF Tea Joyful Heart — through 5 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Bosentan interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Bosentan interactionChamomileCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Bosentan interactionFennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Bosentan interactionCorianderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Coriander + Bosentan interactionBrincidofovirTembexa
How Brincidofovir interacts with CCF Tea Joyful Heart — through 1 ingredient. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Brincidofovir interactionCeliprololCelicard
How Celiprolol interacts with CCF Tea Joyful Heart — through 2 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp), Celiprolol (celicard) +1 Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Celiprolol interactionCorianderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Coriander + Celiprolol interactionCerivastatin SodiumBaycol
How Cerivastatin Sodium interacts with CCF Tea Joyful Heart — through 2 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Cerivastatin Sodium interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Cerivastatin Sodium interactionCinoxacinCinobac
How Cinoxacin interacts with CCF Tea Joyful Heart — through 3 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Cinoxacin interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Cinoxacin interactionCorianderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Coriander + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with CCF Tea Joyful Heart — through 4 ingredients. Tap an ingredient for the detail:
OrangeQuinolone Antibiotics, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Read the full Orange + Ciprofloxacin interactionCorianderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Coriander + Ciprofloxacin interactionFennelCiprofloxacin (cipro) Moderate
Interaction Summary
Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.
Read the full Fennel + Ciprofloxacin interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Ciprofloxacin interactionCiprofloxacin, HydrocortisoneCipro HC Otic
How Ciprofloxacin, Hydrocortisone interacts with CCF Tea Joyful Heart — through 1 ingredient. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Ciprofloxacin, Hydrocortisone interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with CCF Tea Joyful Heart — through 1 ingredient. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Clinafloxacin interactionEnoxacinPenetrex
How Enoxacin interacts with CCF Tea Joyful Heart — through 2 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Enoxacin interactionCorianderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Coriander + Enoxacin interactionEtoposideEtopophos, VePesid, VP16
How Etoposide interacts with CCF Tea Joyful Heart — through 3 ingredients. Tap an ingredient for the detail:
OrangeP-glycoprotein Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Orange + Etoposide interactionFennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Etoposide interactionChamomileCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Etoposide interactionEzetimibe, AtorvastatinLiptruzet
How Ezetimibe, Atorvastatin interacts with CCF Tea Joyful Heart — through 4 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Ezetimibe, Atorvastatin interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Ezetimibe, Atorvastatin interactionFennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Ezetimibe, Atorvastatin interactionChamomileCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Ezetimibe, Atorvastatin interactionFexofenadineAllegra
How Fexofenadine interacts with CCF Tea Joyful Heart — through 3 ingredients. Tap an ingredient for the detail:
OrangeFexofenadine (allegra), P-glycoprotein Substrates +1 Major
Interaction Summary
Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Read the full Orange + Fexofenadine interactionFennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Fexofenadine interactionChamomileCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Fexofenadine interactionFexofenadine, PseudoephedrineAllegra D
How Fexofenadine, Pseudoephedrine interacts with CCF Tea Joyful Heart — through 3 ingredients. Tap an ingredient for the detail:
OrangeP-glycoprotein Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) +1 Major
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Orange + Fexofenadine, Pseudoephedrine interactionChamomileCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Fexofenadine, Pseudoephedrine interactionFennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Fexofenadine, Pseudoephedrine interactionFluvastatinLescol, Lescol XL
How Fluvastatin interacts with CCF Tea Joyful Heart — through 3 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Fluvastatin interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Fluvastatin interactionChamomileCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Fluvastatin interactionGatifloxacinTequin, Tequin Injection
How Gatifloxacin interacts with CCF Tea Joyful Heart — through 3 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Gatifloxacin interactionCorianderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Coriander + Gatifloxacin interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Gatifloxacin interactionGemifloxacinFactive
How Gemifloxacin interacts with CCF Tea Joyful Heart — through 1 ingredient. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Gemifloxacin interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with CCF Tea Joyful Heart — through 6 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Glyburide interactionCuminAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cumin might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cumin + Glyburide interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Glyburide interactionHoly BasilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Holy Basil + Glyburide interactionChamomileCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Glyburide interactionCorianderAntidiabetes Drugs, Photosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Coriander + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with CCF Tea Joyful Heart — through 6 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Glyburide, Metformin interactionCorianderPhotosensitizing Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Coriander + Glyburide, Metformin interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Glyburide, Metformin interactionCuminAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cumin might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cumin + Glyburide, Metformin interactionChamomileCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Glyburide, Metformin interactionHoly BasilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Holy Basil + Glyburide, Metformin interactionGrepafloxacinRaxar
How Grepafloxacin interacts with CCF Tea Joyful Heart — through 2 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Grepafloxacin interactionChamomileCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Grepafloxacin interactionIrinotecanCamptosar, Onivyde
How Irinotecan interacts with CCF Tea Joyful Heart — through 3 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Irinotecan interactionFennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Irinotecan interactionChamomileCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Irinotecan interactionIrinotecan Hydrochloride
How Irinotecan Hydrochloride interacts with CCF Tea Joyful Heart — through 3 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Irinotecan Hydrochloride interactionChamomileCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Irinotecan Hydrochloride interactionFennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Irinotecan Hydrochloride interactionIsoniazid, Pyrazinamide, RifampinRifater
How Isoniazid, Pyrazinamide, Rifampin interacts with CCF Tea Joyful Heart — through 4 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Isoniazid, Pyrazinamide, Rifampin interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Isoniazid, Pyrazinamide, Rifampin interactionCuminRifampin (rifadin) Moderate
Interaction Summary
Theoretically, cumin might increase the effects and adverse effects of rifampin.
Read the full Cumin + Isoniazid, Pyrazinamide, Rifampin interactionCorianderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Coriander + Isoniazid, Pyrazinamide, Rifampin interactionIsoniazid, RifampinRifamate
How Isoniazid, Rifampin interacts with CCF Tea Joyful Heart — through 3 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Isoniazid, Rifampin interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Isoniazid, Rifampin interactionCuminRifampin (rifadin) Moderate
Interaction Summary
Theoretically, cumin might increase the effects and adverse effects of rifampin.
Read the full Cumin + Isoniazid, Rifampin interactionIvermectinMectizan, Sklice, Soolantra, Stromectol
How Ivermectin interacts with CCF Tea Joyful Heart — through 1 ingredient. Tap an ingredient for the detail:
OrangeP-glycoprotein Substrates, Ivermectin (stromectol, Others) Major
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Orange + Ivermectin interactionLevofloxacinLeva-pak, Levaquin, Levaquin Injection
How Levofloxacin interacts with CCF Tea Joyful Heart — through 3 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Levofloxacin interactionCorianderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Coriander + Levofloxacin interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Levofloxacin interactionLevofloxacin (ophthalmic)Levofloxacin
How Levofloxacin (ophthalmic) interacts with CCF Tea Joyful Heart — through 1 ingredient. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Levofloxacin (ophthalmic) interactionLomefloxacinMaxaquin
How Lomefloxacin interacts with CCF Tea Joyful Heart — through 3 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Lomefloxacin interactionCorianderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Coriander + Lomefloxacin interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Lomefloxacin interactionLovastatinAltocor, Mevacor
How Lovastatin interacts with CCF Tea Joyful Heart — through 4 ingredients. Tap an ingredient for the detail:
OrangeOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange + Lovastatin interactionFennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Lovastatin interactionSpearmintHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Lovastatin interactionChamomileCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile + Lovastatin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in CCF Tea Joyful Heart with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Chamomile
Cns Depressants
Theoretically, German chamomile might have additive effects when used with CNS depressants.
German chamomile has mild sedative effects. Theoretically, concomitant use with drugs with sedative properties can cause additive effects and side effects.
Contraceptive Drugs
Theoretically, large amounts of German chamomile might reduce the effectiveness of oral contraceptives.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, concomitant use of large amounts of German chamomile might interfere with contraceptive drugs through competition for estrogen receptors.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2C9. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2C9 in patients taking German chamomile.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2D6. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2D6 in patients taking German chamomile.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP3A4. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP3A4 in patients taking German chamomile.
Estrogens
Theoretically, large amounts of German chamomile might reduce the effectiveness of estrogens.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, large amounts of German chamomile might interfere with hormone replacement therapy through competition for estrogen receptors.
Tamoxifen (Nolvadex)
Theoretically, large amounts of German chamomile might interfere with the activity of tamoxifen.
In vitro, German chamomile has demonstrated antiestrogenic activity.
Warfarin (Coumadin)
German chamomile might increase the effects of warfarin and increase the risk of bleeding.
In one case, a 70-year-old female taking warfarin developed retroperitoneal hematoma and bilateral recti muscle bleeding along with an INR of 7.9 following ingestion of German chamomile tea 4-5 cups daily and use of a topical chamomile-based lotion applied 4-5 times daily.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
In vitro and animal research shows that German chamomile might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP1A2 in patients taking German chamomile.
Fennel
Anticoagulant/Antiplatelet Drugs
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.
Ciprofloxacin (Cipro)
Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.
Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.
Contraceptive Drugs
Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.
Some constituents of fennel have estrogenic activity.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.
Estrogens
Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.
Some constituents of fennel have estrogenic activity.
Tamoxifen (Nolvadex)
Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.
Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.
Coriander
Antidiabetes Drugs
Theoretically, coriander might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Evidence from animal research suggests that coriander fruit and coriander extract can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Antihypertensive Drugs
Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Evidence from animal research suggests that coriander fruit can lower blood pressure.
Cns Depressants
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Evidence from animal research suggests that coriander fruit extract has sedative effects.
Photosensitizing Drugs
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Evidence from in vitro research suggests that coriandrin, a constituent of coriander, has photosensitizing effects.
Spearmint
Cns Depressants
Theoretically, spearmint might alter the sedative effects of CNS depressants.
Animal research suggests that (-)-carvone, a major constituent of spearmint, has sedative effects. However, in humans, chewing spearmint-flavored gum induced arousal effects.
Hepatotoxic Drugs
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Animal research suggests that drinking spearmint tea for 30 days can increase markers of liver damage, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and cause liver degeneration and necrosis, in a dose-dependent manner. This effect has not been reported in humans.
Orange
Celiprolol (Celicard)
Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.
Ivermectin (Stromectol, Others)
Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.
Pravastatin (Pravachol)
Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.
Fexofenadine (Allegra)
Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.
P-Glycoprotein Substrates
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.
Quinolone Antibiotics
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.
Holy Basil
Anticoagulant/Antiplatelet Drugs
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.
Antidiabetes Drugs
Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.
Pentobarbital (Nembutal)
Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.
Cumin
Anticoagulant/Antiplatelet Drugs
Theoretically, cumin might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro evidence suggests that cumin can inhibit platelet aggregation. Theoretically, cumin might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Antidiabetes Drugs
Theoretically, cumin might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that cumin can lower blood sugar in diabetic animals. However, research in humans with and without diabetes has found conflicting results.
Rifampin (Rifadin)
Theoretically, cumin might increase the effects and adverse effects of rifampin.
Animal research suggests that an aqueous extract of cumin containing a specific flavonoid glycoside can increase the bioavailability and plasma levels of rifampin.
Brand information
Manufacturer and brand details for CCF Tea Joyful Heart, from the product label.
Banyan Botanicals
See all Banyan Botanicals products- Name
- Banyan Botanicals
- City
- Albuquerque
- State
- NM
- ZipCode
- 87113
- Phone Number
- 1-800-953-6424
- Web Address
- banyanbotanicals.com
CCF Tea Joyful Heart by Banyan Botanicals: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind CCF Tea Joyful Heart’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Holy Basil
Interacts with 212 drugsHoly basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and preliminary. It is generally well tolerat...
Read the full Holy Basil monograph → Herb & supplement monographGerman Chamomile
Interacts with 960 drugsGerman chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible benefits for mild anxiety and some skin o...
Read the full German Chamomile monograph → Herb & supplement monographFennel
Interacts with 740 drugsFennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...
Read the full Fennel monograph → Herb & supplement monographSweet Orange
Interacts with 246 drugsSweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...
Read the full Sweet Orange monograph → Herb & supplement monographSpearmint
Interacts with 579 drugsSpearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild hormone-related issues (such as excess facia...
Read the full Spearmint monograph → Herb & supplement monographCoriander
Interacts with 717 drugsCoriander (also called cilantro) is a common cooking herb and spice that has long been used in traditional medicine for digestive complaints. As a food it is generally safe for most people,...
Read the full Coriander monograph → Herb & supplement monographCumin
Interacts with 211 drugsCumin is a common cooking spice that has a long history in traditional medicine for digestion and other complaints. Food amounts are generally safe for most people, but the evidence for medi...
Read the full Cumin monograph →Sources & How We Checked
CCF Tea Joyful Heart's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 99 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Holy Basil 8 references
- Agrawal P, Rai V, Singh RB. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int J Clin Pharmacol Ther 1996;34:406-9.
- Sakina MR, Dandiya PC, Hamdard ME, Hameed A. Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract. J Ethnopharmacol 1990;28:143-50. PubMed
- Singh S, Rehan HM, Majumdar DK. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol 2001;78:139-43. PubMed
- Mondal, S., Varma, S., Bamola, V. D., Naik, S. N., Mirdha, B. R., Padhi, M. M., Mehta, N., and Mahapatra, S. C. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J PubMed
- Agarwal, P. and Nagesh, L. Comparative evaluation of efficacy of 0.2% Chlorhexidine, Listerine and Tulsi extract mouth rinses on salivary Streptococcus mutans count of high school children--RCT. Contemp.Clin Trials 2011;32(6):802-808. PubMed
- Vohora, S. B., Garg, S. K., and Chaudhury, R. R. Antifertility screening of plants. 3. Effect of six indigenous plants on early pregnancy in albino rats. Indian J Med Res 1969;57(5):893-899.
- Khanna S, Gupta SR, Grover JK. Effect of long term feeding of tulsi (Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J Exp Biol 1986;24(5):302-4.
- Somasundaram G, Manimekalai K, Salwe KJ, Pandiamunian J. Evaluation of the antidiabetic effect of Ocimum sanctum in type 2 diabetes patients. Int J Life Sci Pharma Res 2012;2(3):75-81.
German Chamomile 15 references
- Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989;84:353-8. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Viola H, Wasowski C, Levi de Stein M, et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 1995;61:213-6.
- van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1982;8:143. PubMed
- van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1987;16:50-1. PubMed
- Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine 1994;1:161-71. PubMed
- Avallone R, Zanoli P, Puia G, et al. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol 2000;59:1387-94. PubMed
- Kassi E, Papoutsi Z, Fokialakis N, et al. Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties. J Agric Food Chem 2004;52:6956-61. PubMed
- Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
- Segal R, Pilote L. Warfarin interaction with Matricaria chamomilla. CMAJ 2006;174:1281-2. PubMed
- Loggia RD, Traversa U, Scarcia V, et al. Depressive effects of Chamomilla recutita (L.) Rausch, tubular flowers, on central nervous system in mice. Pharmacol Res Commun 1982;14(2):153-162. PubMed
- Ganzera M, Schneider P, Stuppner H. Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major constituents on human cytochrome P450 enzymes. Life Sci 2006;78(8):856-861. PubMed
- Benito P, Rodríguez-Perez R, García F, Juste S, Moneo I, Caballero ML. Occupational allergic rhinoconjunctivitis induced by Matricaria chamomilla with tolerance of chamomile tea. J Investig Allergol Clin Immunol. 2014;24(5):369-70. No abstract available.
- Braga FT, Santos AC, Bueno PC, et al. Use of Chamomilla recutita in the prevention and treatment of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized, controlled, phase II clinical trial. Cancer Nurs 2015;38(4):32 PubMed
- Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety T
Fennel 17 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Zhu M, Wong PY, Li RC. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol 1999;51:1391-6.
- Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
- Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
- Rosti L, Nardini A, Bettinelli ME, Rosti D. Toxic effects of a herbal tea mixture in two newborns. Acta Paediatrica 1994;83:683. PubMed
- Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
- Tognolini, M., Ballabeni, V., Bertoni, S., Bruni, R., Impicciatore, M., and Barocelli, E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacol.Res 2007;56(3):254-260. PubMed
- Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed
- Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
- Subehan, Zaidi, S. F., Kadota, S., and Tezuka, Y. Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. J Agric.Food Chem. 12-12-2007;55(25):101 PubMed
- LEVY, S. B. Bronchial asthma due to ingestion of fennel and fennel seed. Ann.Allergy 1948;6(4):415.
- Ottolenghi, A., De Chiara, A., Arrigoni, S., Terracciano, L., and De Amici, M. [Diagnosis of food allergy caused by fruit and vegetables in children with atopic dermatitis]. Pediatr Med Chir 1995;17(6):525-530.
- Trabace L, Tucci P, Ciuffreda L, et al. "Natural" relief of pregnancy-related symptoms and neonatal outcomes: above all do no harm. J Ethnopharmacol. 2015;174:396-402. PubMed
- Denaxa D, Arkwright PD. Fennel as a cause of immediate hypersensitivity to toothpaste. Ann Allergy Asthma Immunol. 2020;125(1):99-100. PubMed
- Lee HW, Ang L, Lee MS, Alimoradi Z, Kim E. Fennel for reducing pain in primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials. Nutrients 2020;12(11):3438. PubMed
- Mathew T, John SK, Javali M, Vasireddy M, Nadig R, Sarma GRK. Substance use related cluster headache: A case series. Headache 2022;62(7):908-910. PubMed
Sweet Orange 17 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- FDA, CFSAN. FDA-approved potassium health claim notification for potassium containing foods. 2000. Available at: www.cfsan.fda.gov/~dms/hclm-k.html.
- Kurowska EM, Spence JD, Jordan J, et al. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 2000;72:1095-100. PubMed
- Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
- Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
- Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
- Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 2004;75:184-90.
- Tian R, Koyabu N, Takanaga H, et al. Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates. Pharm Res 2002;19:802-9. PubMed
- Vanapalli SR, Chen Y, Ellingrod VL, et al. Orange juice decreases the oral bioavailability of ivermectin in health volunteers. Clin Pharmacol Ther 2003;73 (Abstract PDII-A-10):P94.
- Huang SM, Lesko LJ. Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned? J Clin Pharmacol 2004;44:559-69. PubMed
- Koitabashi Y, Kumai T, Matsumoto N, et al. Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, in rats and healthy human subjects. Life Sci 2006;78:2852-9. PubMed
- Takanaga H, Ohnishi A, Yamada S, et al. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 2000;293:230-6. DOI
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Cumin 10 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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