Major interaction on record — check this product against your medications before combining. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

CODmega Ingredients & Drug Interactions

by Garden of Life

Capsule Category: Fat/fatty Acid
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

CODmega is a dietary supplement by Garden of Life with 4 active ingredients. Its ingredients are commonly taken for eye and vision health, skin health and acne, immune support.Based on those ingredients, 387 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin A. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of CODmega by Garden of Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (1,095 mg) without saying how much of each component you get.

CODmega contains 4 active ingredients: eicosapentaenoic acid and docosahexaenoic acid (both omega-3 fatty acids from fish), vitamin A, and a blend called total omega-3 fatty acids. The formula is built on concentrated fish oils and cod liver oil as the base.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support brain nerve bone skin eye and immune health.
  • We looked for evidence on: Cognitive function, Child development, Infant development, Aging skin, Wrinkled skin, Night vision — and 2 related terms.
  • The strongest evidence on file: Vitamin A is rated "Possibly Effective" for Aging skin (Natural Medicines).
  • Also on file: Vitamin A is rated "Possibly Effective" for Night vision, Wrinkled skin.
  • Also on file: Vitamin A is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Infant development, Child development.

Vitamin A in this product is effective for vitamin A deficiency and has possibly effective evidence for oral leukoplakia, aging skin, measles, ulcerative colitis, and bronchopulmonary dysplasia. We hold no effectiveness data on the omega-3 fatty acids in this product in our monographs.

The evidence, ingredient by ingredient Vitamin A

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin A is generally well tolerated at recommended doses, but the safety data cautions that high doses build up in your body and can become toxic. The facts note that recommended amounts are appropriate, but high-dose vitamin A — especially as retinol — can cause birth defects and should be avoided in pregnancy.

At very high doses, vitamin A can cause serious effects like headache, vision changes, and in extreme cases, liver damage or coma. Chronic use of large amounts may cause dry skin, hair loss, and skin peeling.

We hold no safety or adverse-effect data on the two omega fatty acids we could not check (eicosapentaenoic acid and other omegas).

Side effects, ingredient by ingredient Vitamin A

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin A.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 388 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take retinoids (isotretinoin, tretinoin — Major severity), blood thinners like warfarin (Moderate), tetracycline antibiotics such as doxycycline (Moderate), or drugs that stress the liver (Moderate). Altogether, these interactions span 388 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may work for you if you're correcting a vitamin A deficiency or exploring vitamin A for skin or digestive conditions — but the vitamin A content means you need to know your other medications first. If you take a retinoid, blood thinner, or tetracycline antibiotic, talk with your doctor or pharmacist before starting.

Stick to recommended doses and discuss this product with your own healthcare provider, especially if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CODmega, straight from the product label.

Brand Garden of Life
Barcode (UPC) 658010112260
Net contents 90 Licap(s)(R)
Market status On market
Date entered into DSLD Dec 24, 2013
DSLD ID 28483
Product type Fat/fatty Acid
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CODmega by Garden of Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Licap(s)
Maximum serving Sizes:
1 Licap(s)
Servings per container
30
UPC/BARCODE
658010112260
IngredientAmount% DV
Calories20 {Calories}--
Calories from Fat20 {Calories}--
Total Fat2 Gram(s)3%
Eicosapentaenoic Acid400 mg--
Docosahexaenoic Acid600 mg--
Cholesterol5 mg2%
Vitamin A400 IU8%
Total Omega-3 Fatty Acids1095 mg--
Other Omegas95 mg--

Other ingredients: Concentrated fish oils, Gelatin, Cod Liver Oil, natural Lemon flavor, Peppermint Oil, natural Mixed Tocopherols, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

CODmega(R) is a unique combination of wild fish and cod liver oils that provides 400 mg of EPA and 600 mg of DHA Omega-3 fatty acids.

Licaps(R) is a registered trademark Capsugel

General Statements

Supportive but not conclusive research shows that the consumption of EPA and DHA Omega-3 fatty acids may reduce the risk of coronary heart disease.

CODmega(R) is molecularly distilled and undergoes quality control measures which include independent laboratory testing to exacting purity standard for heavy metals, PCBs, dioxins and other potential contaminants.

We buy 100% Certified Renewable Energy

Excellent Source of Omega-3 Fatty Acids

Made in the U.S.A.

Formula

+One serving of CODmega(R) provides 1,000 mg of EPA and DHA Omega-3 fatty acids to support brain, nerve, bone, skin, eye and immune system health.+

CODmega(R) contains high quality cod liver oil from the deep, clean arctic waters of Norway.

CODmega(R) contains a pleasant lemon mint flavor to help reduce aftertaste; and utilizes unique Licaps(R) technology for easy-to-swallow capsules that are less oxygen permeable.

Wild Fish & Cod Live Oil Complex

Contains: Soy

Precautions

Warning: Do not take this product if you are using blood thinners or anticipate surgery. Consult with a physician before taking this product if you are pregnant, diabetic or allergic to iodine or under medical supervision.

Warning: Do not take this product if you are using blood thinners or anticipate surgery. Consult with a physician before taking this product if you are pregnant, diabetic or allergic to iodine or under medical supervision.

Warning: Do not take this product if you are using blood thinners or anticipate surgery. Consult with a physician before taking this product if you are pregnant, diabetic or allergic to iodine or under medical supervision.

Keep out of reach of children.

Do not use if safety seal is broker or missing.

Not intended for children.

Formulation

Contains no artificial colors or preservatives.

Dairy Free. Gluten Fee.

Storage

Store in cool, dry place.

Seals/Symbols

Recyclable Bottle

CERTIFIED RENEWABLE ENERGY (R) Green-e.org

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

CM90L-032511-033011

FDA Statement of Identity

Whole Food Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Adults take one CODmega(R) three times per day with meals unless otherwise advised by your healthcare practitioner.

See for yourself

CODmega by Garden of Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in CODmega by Garden of Life

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Licap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin A

Interacts with
387 drugs
400 IU per serving

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplemen...

Vitamin A monograph & interactions

Total Omega-3 Fatty Acids

1095 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Other Omegas

Other (inactive) ingredients: Concentrated fish oils, Gelatin, Cod Liver Oil, Natural Lemon flavor, Peppermint Oil, Natural Mixed Tocopherols, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

CODmega by Garden of Life Drug Interactions

Want to check YOUR meds against CODmega?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
387Drugs
9 Major 378 Moderate

Ingredients driving the most interactions

Vitamin A 387

Each ingredient & the kinds of drugs it affects

For each ingredient in CODmega with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin A4 drug types · 387 drugs

Retinoids

Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Retinoids, which are vitamin A derivatives, could have additive toxic effects when taken with vitamin A supplements.

Likelihood Probable Evidence D
Hepatotoxic Drugs

Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
The tolerable upper intake level (UL) is the highest level of intake that is likely to pose no risk of adverse effects. Doses of vitamin A above the UL can cause hepatotoxicity, ranging from elevated liver enzymes to liver failure.

Likelihood Possible Evidence C
Tetracycline Antibiotics

Theoretically, taking tetracycline antibiotics with high doses of vitamin A can increase the risk of pseudotumor cerebri.
Benign intracranial hypertension (pseudotumor cerebri) can occur with tetracyclines and with acute or chronic vitamin A toxicity. Case reports suggest that taking tetracyclines and vitamin A concurrently can increase the risk of this condition. Avoid high doses of vitamin A in people taking tetracyclines chronically.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, high doses of vitamin A could increase the risk of bleeding with warfarin.
Vitamin A toxicity is associated with hemorrhage and hypoprothrombinemia, possibly due to vitamin K antagonism. Advise patients taking warfarin to avoid doses of vitamin A above the tolerable upper intake level of 10,000 IU/day for adults.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for CODmega, from the product label.

Garden of Life

See all Garden of Life products
Name
Garden of Life LLC
Street Address
5500 Village Blvd
City
West Palm Beach
State
FL
ZipCode
33407
Web Address
www.gardenoflife.com
Pharmacist Counseling Corner

CODmega by Garden of Life: Common Questions

Does CODmega by Garden of Life interact with any medications?
Yes. Based on its ingredients, CODmega has a known interaction with 387 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CODmega contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is the vitamin A in this product safe during pregnancy?
The data shows conflicting ratings for vitamin A in pregnancy — one says likely safe, another says possibly unsafe. Because high doses can cause birth defects, the safety notes stress avoiding high-dose supplements unless your doctor directs it. Talk with your obstetrician or pharmacist before taking this during pregnancy so they can advise you based on your dose and health history.
What is vitamin A actually used for in the body?
Vitamin A supports your vision, immune system, and skin health. This product's effectiveness data shows it works for vitamin A deficiency and has some evidence for skin conditions, skin aging, measles, and digestive issues like ulcerative colitis.
Can I take this if I have liver disease?
Vitamin A can stress the liver, especially at high doses, and the facts warn that combining it with other liver-damaging drugs may increase that risk. If you have liver disease or take medications that affect your liver, discuss this product with your doctor or pharmacist before starting.
What are the omega fatty acids in here for?
This product contains eicosapentaenoic acid and docosahexaenoic acid — two omega-3 fatty acids commonly associated with heart and brain health. We don't hold effectiveness data for these specific ingredients in our monographs, though omega-3s are widely studied.
Will I get side effects from the vitamin A?
At recommended doses, vitamin A is generally well tolerated. At very high doses or with long-term overuse, it can cause headache, vision changes, dry skin, hair loss, and skin peeling. Serious effects like liver damage or increased brain pressure are rare but can occur with extreme overdose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CODmega is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CODmega label
Sources

Sources & How We Checked

CODmega's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin A 31 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Griffiths JK. The vitamin A paradox. J Pediatr 2000;137:604-7.. PubMed
  3. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. FDA Talk Paper. Vitamin A and birth defects (T95-56). Food and Drug Administration, U.S. Department of Health and Human Services, Rockville, MD. October 6, 1995.
  6. Russell RM. The vitamin A spectrum: from deficiency to toxicity. Am J Clin Nutr 2000;71:878-84. PubMed
  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  8. Feskanich D, Singh V, Willett WC, Colditz GA. Vitamin A intake and hip fractures among postmenopausal women. JAMA 2002;287:47-54. PubMed
  9. Melhus H, Michaelsson K, Kindmark A, et al. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med 1998;129:770-8. PubMed
  10. Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003;348:287-94.. PubMed
  11. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer 2000;88:737-48.. DOI
  12. Meyskens FL Jr, Graham V, Chvapil M, et al. A phase I trial of beta-all-trans-retinoic acid delivered via a collagen sponge and a cervical cap for mild or moderate intraepithelial cervical neoplasia. J Natl Cancer Inst 1983;71:921-5..
  13. Hathcock JN, Hattan DG, Jenkins MY, et al. Evaluation of vitamin A toxicity. Am J Clin Nutr 1990;52:183-202.. PubMed
  14. Walters BN, Gubbay SS. Tetracycline and benign intracranial hypertension: report of five cases. Br Med J 1981;282:19-20.. PubMed
  15. Pearson MG, Littlewood SM, Bowden AN. Tetracycline and benign intracranial hypertension (letter). Br Med J 1981;282:568-9.. PubMed
  16. Azais-Braesco V, Pascal G. Vitamin A in pregnancy: requirements and safety limits. Am J Clin Nutr 2000;71:1325S-33S. PubMed
  17. Smedts HP, de Vries JH, Rakhshandehroo M, et al. High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring. BJOG 2009;116:416-23. PubMed
  18. Grotto, I., Mimouni, M., Gdalevich, M., and Mimouni, D. Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis. J Pediatr 2003;142(3):297-304. PubMed
  19. Mahalanabis, D., Lahiri, M., Paul, D., Gupta, S., Gupta, A., Wahed, M. A., and Khaled, M. A. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute l
  20. Long, K. Z., Montoya, Y., Hertzmark, E., Santos, J. I., and Rosado, J. L. A double-blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mex
  21. Fritz, H., Kennedy, D., Fergusson, D., Fernandes, R., Doucette, S., Cooley, K., Seely, A., Sagar, S., Wong, R., and Seely, D. Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis. PLoS.One. 2011;6(6):e21107. PubMed
  22. Mayo-Wilson, E., Imdad, A., Herzer, K., Yakoob, M. Y., and Bhutta, Z. A. Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis. BMJ 2011;343:d5094. PubMed
  23. Mazumder S, Taneja S, Bhatia K, Yoshida S, Kaur J, Dube B, Toteja GS, Bahl R, Fontaine O, Martines J, Bhandari N; Neovita India Study Group. Efficacy of early neonatal supplementation with vitamin A to reduce mortality in infancy in Haryana, India (Neovit
  24. Baineni R, Gulati R, Delhi CK. Vitamin A toxicity presenting as bone pain. Arch Dis Child. 2017;102(6):556-8. PubMed
  25. Darlow BA, Graham PJ, Rojas-Reyes MX. Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants. Cochrane Database Syst Rev. 2016;(8):CD000501. PubMed
  26. Haider BA, Sharma R, Bhutta ZA. Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle income countries. Cochrane Database Syst Rev. 2017;2:CD006980. PubMed
  27. Mohammad YM, Raslan IR, Al-Hussain FA. Idiopathic Intracranial Hypertension Induced by Topical Application of Vitamin A. J Neuroophthalmol. 2016;36(4):412-3. PubMed
  28. Masnadi Shirazi K, Nikniaz Z, Masnadi Shirazi A, Rohani M. Vitamin A supplementation decreases disease activity index in patients with ulcerative colitis: A randomized controlled clinical trial. Complement Ther Med. 2018 Dec;41:215-219. PubMed
  29. Ding Y, Hu P, Yang Y, et al. Impact of maternal daily oral low-dose vitamin A supplementation on the mother-infant pair: a randomised placebo-controlled trial in China. Nutrients 2021;13(7):2370. PubMed
  30. Knapik JJ, Hoedebecke SS. Vitamin A and bone fractures: systematic review and meta-analysis. J Spec Oper Med 2021;21(2):100-7. PubMed
  31. Imdad A, Mayo-Wilson E, Haykal MR, et al. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst Rev 2022;3(3):CD008524. PubMed

See these in context on the Vitamin A monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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