Interactions on record — worth a quick check against your medications. Based on 4 of 10 ingredients. Check your meds →
Dietary supplement

Digestive Enzymes Ingredients & Drug Interactions

by Return Healthy

Digestive Enzymes label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Digestive Enzymes is a dietary supplement by Return Healthy with 10 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digestive Enzymes by Return Healthy

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Enzymes by Return Healthy — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digestive Enzymes by Return Healthy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 10 active ingredients.
  • “GastroENZ Proprietary Blend” is a proprietary blend — the label gives one combined amount (180 mg) without saying how much of each component you get.

This formula contains 10 active digestive enzymes: lactase breaks down milk sugar; lipase helps digest fats; betaine HCl increases stomach acid to support digestion; glucoamylase, invertase, and amylases break down carbohydrates; pepsin and proteases work on proteins; and peptidase breaks proteins into smaller pieces. Ox bile extract supports fat digestion.

The capsule also contains inactive ingredients (hypromellose, microcrystalline cellulose, medium chain triglycerides, and water) that serve as fillers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Aid digestion and reduce digestive discomfort.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Diarrhea, Bloating and gas, Indigestion, Food intolerance.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Diarrhea, Dyspepsia.

The evidence for most of these enzymes isn't established in the data we hold. Lactase is effective for lactose intolerance — if you can't digest milk sugar well, lactase can help.

For the other ingredients and conditions, we don't have reliable evidence to say whether they work. That doesn't mean they don't; it means the studies aren't there yet to back up their use for dyspepsia, inflammatory bowel disease, or other digestive complaints.

The evidence, ingredient by ingredient Betaine Hydrochloride Lactase Lipase Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these enzymes are generally well tolerated in adults. Lactase has rare reports of allergic reactions in people exposed to powdered forms.

Pepsin and proteases may occasionally cause digestive upset or allergic reactions in sensitive people. Betaine HCl is the one to be cautious with — it irritates the stomach and shouldn't be used if you have ulcers, gastritis, or acid reflux disease, as it could make those conditions worse.

For pregnancy: lactase is likely safe, but there isn't enough safety data for lipase, betaine HCl (which should be avoided), pepsin, or proteases. We don't have pregnancy or breastfeeding information on file for some ingredients.

If you're pregnant or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Betaine Hydrochloride Lactase Lipase Proteolytic Enzymes (proteases)

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any proton pump inhibitors (PPIs), H2-blockers, or antacids — betaine HCl in this formula may reduce how well they work. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Return Healthy Digestive Enzymes may help if you have trouble digesting milk sugar, and the enzymes are generally well tolerated. The main concern is betaine HCl — if you take acid-reducing medications like PPIs or H2-blockers, this product could interfere with them.

If you have ulcers or reflux disease, avoid it altogether. Check your medications against the interaction tool on this page, and talk with your doctor or pharmacist before starting, especially if you have a digestive condition or take prescription meds.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Enzymes, straight from the product label.

Brand Return Healthy
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 282158
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Enzymes by Return Healthy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
Lactase0 NP--
Lipase0 NP--
Betaine HCl200 mg--
Glucoamylase0 NP--
Invertase0 NP--
Pepsin0 NP--
Peptidase0 NP--
Ox Bile extract0 NP--
Proteases0 NP--
Amylases0 NP--
GastroENZ Proprietary Blend180 mg--

Other ingredients: Hypromellose, Water, Microcrystalline Cellulose, Medium Chain Triglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Digestive Enzymes contains a combination of enzymes that are capable of aiding digestion. Betaine HCI and the enzyme pepsin aid in the digestion of protein. This formula also contains special proteolytic enzymes as well as amylase, lactase, invertase, and lipase to further aid the digestion of protein, starch, lactose (milk sugar), and fats.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Notice: Color, size or shape may appear different between lots.

Storage

Store at room temperature.

Precautions

Keep out of reach of children.

Report any adverse reactions to: (435) 624-1329

Brand IP Statement(s)

Return Healthy Empowered wellness

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take one capsule per day with a meal, or as directed by your health care practitioner.

General Statements

For more information, visit ReturnHealthy.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Enzymes by Return Healthy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Enzymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Enzymes by Return Healthy

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine HCl

Interacts with
36 drugs
200 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine HCl monograph & interactions

GastroENZ Proprietary Blend

180 mg per serving

Other (inactive) ingredients: Hypromellose, Water, Microcrystalline Cellulose, Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Enzymes by Return Healthy Drug Interactions

Want to check YOUR meds against Digestive Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine HCl 36

Individual Drug Interactions

The ingredients in Digestive Enzymes interact with 36 drugs. Click any drug to see the details.

1 of the 10 ingredients in Digestive Enzymes interact with drugs. Each result below shows which ingredient is responsible. Betaine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Enzymes with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Enzymes, from the product label.

Return Healthy

See all Return Healthy products
Name
Return Healthy LLC
Street Address
163 W. 1600 S. Suite 4
City
St George
State
UT
ZipCode
84770-6715
Phone Number
(435) 624-1329
Web Address
ReturnHealthy.com
Pharmacist Counseling Corner

Digestive Enzymes by Return Healthy: Common Questions

Does Digestive Enzymes by Return Healthy interact with any medications?
Yes. Based on its ingredients, Digestive Enzymes has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Enzymes contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me digest lactose?
Yes, if lactose intolerance is your issue — lactase is effective for that. If you have trouble digesting milk or dairy, this enzyme can break down that sugar for you.
Can I take this if I'm pregnant?
Lactase is likely safe during pregnancy, but we don't have enough safety data for the other enzymes, and betaine HCl should be avoided. Talk with your doctor or pharmacist before taking it while pregnant — they can weigh the risks and benefits for your situation.
Is this safe if I have acid reflux?
No. Betaine HCl raises stomach acid, which can irritate your esophagus and make reflux worse. Avoid this product if you have reflux disease, ulcers, or gastritis.
What are proteases and pepsin for?
They're enzymes that break down proteins into smaller pieces so your body can digest them more easily. They're common ingredients in digestive enzyme blends.
Can I take this if I'm breastfeeding?
There isn't enough safety data on most of these enzymes while breastfeeding. Check with your doctor or pharmacist first — they can advise you on whether it's okay for your situation.
What's ox bile extract for?
It supports the digestion of fats. Bile naturally helps your body break down and absorb fatty foods, and this extract mimics that role.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Enzymes is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Enzymes label
Go deeper

The Full Monographs Behind Digestive Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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