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Dietary supplement

GABA Ingredients & Drug Interactions

by Superior Source

GABA label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GABA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GABA is a dietary supplement by Superior Source with 2 active ingredients. Its ingredients are commonly taken for sugar substitute / sweetener, blood sugar support in diabetes, weight management.Based on those ingredients, 505 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gamma-Aminobutyric Acid, Stevia leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GABA by Superior Source

Ask about any prescription or over-the-counter medication and we check it for interactions with GABA by Superior Source — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GABA by Superior Source

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. Stevia leaf extract is a sweetener derived from the stevia plant.

Gamma-aminobutyric acid (GABA) is a compound that works as a chemical messenger in your brain and nervous system. The tablet also contains inactive ingredients: lactose, acacia gum, and natural cherry flavor.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Relaxation, anxiety, and sleep support.
  • We looked for evidence on: Anxiety, Insomnia, Stress, Sleep quality, Nervous system relaxation.
  • The closest evidence on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Post-traumatic stress disorder (PTSD).

The facts we hold don't establish reliable evidence for either ingredient. For stevia, the data show insufficient evidence to rate it for blood sugar control, blood pressure, or weight management.

For GABA, evidence is similarly insufficient to rate it for anxiety, attention, athletic performance, cerebral palsy, or chronic bronchitis. If you're considering this product for a specific reason, talk it through with your doctor or pharmacist to see what the stronger evidence supports.

The evidence, ingredient by ingredient Stevia Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Stevia appears generally well tolerated in the purified forms used in food, but whole-leaf stevia and high-dose supplements haven't been well studied — use caution. The most common side effects are mild: abdominal bloating, dizziness, headache, muscle pain, nausea, and numbness, and most resolve within the first week.

Allergic reactions are rare. GABA seems generally well tolerated in the short term, but long-term safety hasn't been well studied.

Common side effects include drowsiness, stomach upset, mild throat burning, muscle weakness, and nausea. Safety information during pregnancy is not on file for either ingredient.

During breastfeeding, the safety data for GABA advises against use; for stevia, there isn't enough data to know either way. Talk with your doctor or pharmacist before taking this product if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Stevia Gamma-aminobutyric Acid (gaba)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Gamma-aminobutyric Acid (gaba), Stevia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 505 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you use lithium (a mood stabilizer) — stevia may raise its levels to unsafe amounts. Also flag blood pressure medications and diabetes medications with your pharmacist, as both ingredients may lower your blood pressure or blood sugar further.

If you take sedatives, sleep aids, or other central nervous system depressants, mention those too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines two ingredients with moderate interactions involving blood pressure medications and stevia's effect on lithium levels. The evidence for either ingredient's effectiveness is insufficient to support most uses.

If you take blood pressure medication, mood stabilizers (especially lithium), diabetes medication, or central nervous system depressants, check with your own doctor or pharmacist before adding this supplement.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GABA, straight from the product label.

Brand Superior Source
Net contents 100 MicroLingual(R) Instant Dissolve Tablet(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 212776
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GABA by Superior Source, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 MicroLingual(R) Tablet(s)
Maximum serving Sizes:
1 MicroLingual(R) Tablet(s)
Servings per container
100
IngredientAmount% DV
Stevia leaf extract2 mg--
Gamma-Aminobutyric Acid100 mg--

Other ingredients: Lactose, Acacia Gum, natural Cherry flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, dissolve one Microlingual tablet under the tongue daily. This product may also be swallowed.

Formulation

GMO free

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GABA by Superior Source label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GABA label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GABA by Superior Source

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 MicroLingual(R) Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Stevia leaf extract

Interacts with
259 drugs
2 mg per serving

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia leaf extract monograph & interactions

Gamma-Aminobutyric Acid

Interacts with
419 drugs
100 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

Gamma-Aminobutyric Acid monograph & interactions

Other (inactive) ingredients: Lactose, Acacia Gum, Natural Cherry flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

GABA by Superior Source Drug Interactions

Want to check YOUR meds against GABA?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
505Drugs
173 Moderate 332 Minor

Ingredients driving the most interactions

Gamma-Aminobutyric Acid 419
Stevia leaf extract 259

Individual Drug Interactions

The ingredients in GABA interact with 505 drugs. Click any drug to see the details.

2 of the 2 ingredients in GABA interact with drugs. Each result below shows which ingredient is responsible. Gamma-Aminobutyric Acid Stevia leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in GABA with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gamma-Aminobutyric Acid2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
Gamma-Aminobutyric Acid full monograph & interactions

Stevia leaf extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GABA, from the product label.

Superior Source

See all Superior Source products
Name
Superior Source
Phone Number
800-421-6175
Web Address
www.superiorsourcevitamins.com
Pharmacist Counseling Corner

GABA by Superior Source: Common Questions

Does GABA by Superior Source interact with any medications?
Yes. Based on its ingredients, GABA has a known interaction with 505 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GABA contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is GABA and what does it do in the body?
GABA is gamma-aminobutyric acid, a chemical messenger in your brain and nervous system that helps produce relaxation and calm. This supplement contains it as an active ingredient, though the strength of the effect from oral supplements isn't clearly established in the data we hold.
Is stevia safe?
Purified stevia in typical food amounts is generally recognized as safe. However, high-dose stevia supplements and whole-leaf stevia haven't been well studied, so use caution if you're taking this product regularly at higher doses.
What side effects should I expect?
The most common side effects are mild: abdominal bloating, dizziness, headache, muscle pain, nausea, and numbness from stevia; drowsiness, stomach upset, mild throat burning, muscle weakness, and nausea from GABA. Most resolve within the first week.
Can I take this while breastfeeding?
Safety information during breastfeeding is not established for stevia. For GABA, the safety data advises against use while breastfeeding. Talk with your doctor or pharmacist about whether this product is appropriate for you.
Does this product help with anxiety?
The evidence we hold is insufficient to rate GABA for anxiety. While the ingredient is thought to promote relaxation, reliable clinical evidence supporting its use isn't established in our data.
Can this help me lose weight?
The evidence we hold is insufficient to rate stevia for weight management. While it's a low-calorie sweetener, we don't have reliable data on whether supplements help with weight loss.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GABA label
Go deeper

The Full Monographs Behind GABA’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph → Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph →
Sources

Sources & How We Checked

GABA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
  8. Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeti
  9. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. PubMed
  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

See these in context on the Stevia monograph →

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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