Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

GastrAcid Ingredients & Drug Interactions

by XYMOGEN

GastrAcid label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GastrAcid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GastrAcid is a dietary supplement by XYMOGEN with 4 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gentian Root Extract, Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GastrAcid by XYMOGEN

Ask about any prescription or over-the-counter medication and we check it for interactions with GastrAcid by XYMOGEN — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GastrAcid by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

GastrAcid contains four active ingredients. Betaine hydrochloride and pepsin are digestive enzymes and cofactors that support stomach acid production and protein breakdown.

L-glutamic acid and gentian root extract round out the blend. The capsule also contains inactive ingredients—hypromellose, water, stearic acid, and silica—that serve as binders and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: promote gastric acidification and digestive health.
  • We looked for evidence on: Dyspepsia, Flatulence, Gastritis, Gastroesophageal reflux disease (GERD), Hypochlorhydria, Indigestion — and 2 related terms.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Gentian is rated "Insufficient Reliable Evidence To Rate" for Gastroesophageal reflux disease (GERD), Flatulence, Gastritis.

The evidence we hold doesn't establish how well any of these ingredients work. Betaine hydrochloride's effectiveness for indigestion (dyspepsia), low thyroid function, diarrhea, rheumatoid arthritis, food sensitivities, and hay fever all carry insufficient evidence ratings.

Gentian root shows the same gap for wound healing, weight loss, sinus inflammation, and gastritis. Pepsin's effectiveness data isn't on file here.

The evidence, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases) Gentian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride and gentian root are generally well tolerated in small amounts by healthy adults, but both can irritate the stomach. Betaine hydrochloride specifically may not be safe if you have ulcers, gastritis, or true acid reflux—it could worsen those conditions.

Pepsin is generally well tolerated but may rarely trigger digestive upset or allergic reactions in sensitive people. During pregnancy, betaine hydrochloride and gentian root should be avoided—there isn't enough safety data.

Pepsin safety in pregnancy hasn't been established either, so medical advice is needed. While breastfeeding, betaine hydrochloride and gentian root are best avoided, and pepsin use isn't recommended without talking to your doctor or pharmacist first.

No safety data is on file for L-glutamic acid.

Side effects, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases) Gentian

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Betaine Hydrochloride, Gentian.
  • The most serious interaction on file is rated Moderate.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood pressure medicine (antihypertensive drugs), check with your pharmacist or doctor first—gentian root may increase how much those drugs lower your blood pressure. If you use H2-blockers, antacids, or proton pump inhibitors for acid control, this product could work against them; your provider may need to adjust timing or doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

GastrAcid is designed to support stomach acid and digestion, but the evidence for how well it works isn't established in the data we hold. It's not for you if you have ulcers, gastritis, or acid reflux—it may make those worse.

If you take blood pressure medicine or acid reducers, talk with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GastrAcid, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 871149002329
Net contents 180 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 303693
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GastrAcid by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
871149002329
IngredientAmount% DV
L-Glutamic Acid350 mg--
Betaine Hydrochloride300 mg--
Pepsin20 mg--
Gentian Root Extract20 mg--

Other ingredients: Hypromellose, Water, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one capsule with or immediately following meals, or as directed by your healthcare professional.

Precautions

Consult your healthcare professional prior to use.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Do not use if tamper seal is damaged.

Cautions: Do not use if there is a current complaint of a peptic or duodenal ulcer.

Storage: Keep closed in a cool, dry place out of reach of children.

Formulation

GastrAcid features a custom blend of ingredients used traditionally and clinically to promote gastric acidification. This formula is targeted to support a healthy digestive pH that, in turn, promotes overall digestive health.

Formulated to Exclude: Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.

Digestive Support Formula

Vegetarian Caps

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage: Keep closed in a cool, dry place out of reach of children.

Brand IP Statement(s)

Copyright 2023 Xymogen

Xymogen Exclusive Professional Formulas

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

ePV (ePedigree Verification) Vegetarian Caps Third-Party Verified GMP Compliant

General Statements

Scan to Learn More! This package is completely recyclable

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See for yourself

GastrAcid by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GastrAcid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GastrAcid by XYMOGEN

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamic Acid

350 mg per serving

Betaine Hydrochloride

Interacts with
36 drugs
300 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Pepsin

No known
interactions
20 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Gentian Root Extract

Interacts with
172 drugs
20 mg per serving Form: Gentiana lutea Root Extract

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...

Gentian Root Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Water, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

GastrAcid by XYMOGEN Drug Interactions

Want to check YOUR meds against GastrAcid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
172 Moderate 36 Minor

Ingredients driving the most interactions

Gentian Root Extract 172
Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in GastrAcid interact with 208 drugs. Click any drug to see the details.

2 of the 4 ingredients in GastrAcid interact with drugs. Each result below shows which ingredient is responsible. Gentian Root Extract Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in GastrAcid with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gentian Root Extract1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian Root Extract full monograph & interactions

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GastrAcid, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

GastrAcid by XYMOGEN: Common Questions

Does GastrAcid by XYMOGEN interact with any medications?
Yes. Based on its ingredients, GastrAcid has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GastrAcid contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have an ulcer or heartburn?
No. Betaine hydrochloride raises stomach acid, which can irritate ulcers and gastritis or make heartburn worse. This product isn't safe for acid reflux. Talk with your doctor about what might work better for you.
Is it safe during pregnancy or breastfeeding?
No. Betaine hydrochloride and gentian root should both be avoided during pregnancy—the safety data just isn't there. While breastfeeding, the same two ingredients aren't recommended without medical advice. Talk with your doctor or pharmacist about what's right for your situation.
What's pepsin, and why is it in here?
Pepsin is an enzyme that breaks down protein in the stomach. It's included to work alongside the stomach acid that betaine hydrochloride produces. It's generally well tolerated, though rarely it can cause digestive upset or allergic reactions.
Will this interfere with my acid reflux medicine?
Yes, possibly. Betaine hydrochloride raises stomach acid, which could make H2-blockers, antacids, and proton pump inhibitors less effective. Talk with your pharmacist or doctor about timing or whether this product is right for you.
Can it cause stomach pain or other side effects?
It may. Betaine hydrochloride and gentian root can upset the stomach in some people, and betaine hydrochloride specifically might cause heartburn. Pepsin rarely triggers digestive upset or allergic reactions. If you notice irritation, stop and talk with your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GastrAcid label
Go deeper

The Full Monographs Behind GastrAcid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph →
Sources

Sources & How We Checked

GastrAcid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Gentian 5 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

See these in context on the Gentian monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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