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Dietary supplement

Glutamine Muscle Support Ingredients & Drug Interactions

by Prime Nutrition Precision Series

Glutamine Muscle Support label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Glutamine Muscle Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Glutamine Muscle Support is a dietary supplement by Prime Nutrition Precision Series with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Glutamine Muscle Support by Prime Nutrition Precision Series

Ask about any prescription or over-the-counter medication and we check it for interactions with Glutamine Muscle Support by Prime Nutrition Precision Series — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Glutamine Muscle Support by Prime Nutrition Precision Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains one active ingredient: L-glutamine, an amino acid your body naturally makes and uses for muscle repair, immune function, and gut health. There are no inactive ingredients listed — you're getting the amino acid itself.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support muscle building and athletic performance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, muscle recovery, muscle protein synthesis, strength training.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Postoperative recovery (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

The evidence supports L-glutamine for sickle cell disease, where it's rated as effective. For HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma, the data suggests it's possibly effective, meaning the research shows some promise but isn't conclusive yet.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated when taken by mouth. The most common side effects are digestive — belching, bloating, constipation, diarrhea, flatulence, and nausea — especially at higher doses (10–30 grams daily).

Headache and musculoskeletal pain have also been reported. A few cases of dizziness and mood changes (mania or hypomania) have appeared in people with bipolar disorder, though these are rare.

If you have kidney or liver disease, use this only under your doctor's supervision. There isn't enough safety data to recommend it during pregnancy or breastfeeding unless your doctor specifically suggests it — talk with your clinician for personalized advice.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist if you take anticonvulsants (seizure medications) — this supplement might reduce how well they work, though the risk hasn't been seen in patients yet. This is a Moderate-level concern that deserves a conversation before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may help with sickle cell disease and possibly with recovery from surgery or critical illness, but the evidence for general muscle support isn't in our data. If you take anticonvulsants, check with your doctor or pharmacist before starting.

For healthy adults without kidney, liver, or seizure concerns, it's generally well tolerated, though digestive side effects are common at higher doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Glutamine Muscle Support, straight from the product label.

Brand Prime Nutrition Precision Series
Barcode (UPC) 689466706055
Net contents 14.1 oz.; 400 Gram(s)
Market status On market
Date entered into DSLD Feb 25, 2015
DSLD ID 42354
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Glutamine Muscle Support by Prime Nutrition Precision Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
80
UPC/BARCODE
689466706055
IngredientAmount% DV
L-Glutamine5 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

-THE BEST OR NOTHING-

GLUTAMINE L- GLutamine can be used to support high intensity training for a variety of goals. L-Glutamine is for users who are aiming to build muscle, promote cell volumazation, decrease muscle fatigue and optimize GH levels.

BUILD MUSCLE MASS* ENHANCE RECOVERY* OPTIMIZE IMMUNE FUNCTION*

WWW.PRIME NUTRITION.COM

80 SERVINGS

Suggested/Recommended/Usage/Directions

PERFORMANCE TRAINING USAGE: As a dietary supplement consume 1 scoop into 4oz of water or juice immediately after a training session. For best results consume an additional scoop before bedtime.

Formula

100% PURE MICRONIZED L-GLUTAMINE

Precautions

WARNING: Not for use for individuals under the age of 18.

Do not use if you are pregnant or nursing.

Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience any adverse symptoms. Improper use of this product may be hazardous to a person's health. Exceeding recommended serving will not improve your results.

FDA Disclaimer Statement

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

No Artificial Colors or Dyes

FDA Statement of Identity

DIETARY SUPPLEMENT

Seals/Symbols

P

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Glutamine Muscle Support by Prime Nutrition Precision Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Glutamine Muscle Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Glutamine Muscle Support by Prime Nutrition Precision Series

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container80 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
5 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions
Interaction report

Glutamine Muscle Support by Prime Nutrition Precision Series Drug Interactions

Want to check YOUR meds against Glutamine Muscle Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine 50

Individual Drug Interactions

The ingredients in Glutamine Muscle Support interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in Glutamine Muscle Support interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Glutamine Muscle Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Glutamine Muscle Support, from the product label.

Prime Nutrition Precision Series

See all Prime Nutrition Precision Series products
Name
Prime Nutrition(R) Prime Nutrition LLC
Street Address
21218 St. Andrews Blvd. Suite 230
City
Boca Raton
State
FL
ZipCode
33434
Pharmacist Counseling Corner

Glutamine Muscle Support by Prime Nutrition Precision Series: Common Questions

Does Glutamine Muscle Support by Prime Nutrition Precision Series interact with any medications?
Yes. Based on its ingredients, Glutamine Muscle Support has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Glutamine Muscle Support contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the most common side effects?
The most frequent side effects are digestive: belching, bloating, constipation, diarrhea, flatulence, and nausea. Headache and muscle pain have also been reported. These tend to show up with higher doses and often improve when you reduce the amount you take.
Is it safe to take while breastfeeding?
There isn't enough safety data to know. Avoid supplement doses while breastfeeding unless your doctor or lactation specialist recommends it. Talk with your clinician for advice tailored to your situation.
Is it safe to take during pregnancy?
L-glutamine is rated likely safe in pregnancy — the safety data supports it. Still, any supplement decision during pregnancy should be made with your doctor, so check with them first.
Does this actually help with muscle growth?
The evidence we have shows L-glutamine is effective for sickle cell disease and possibly effective for muscle wasting from HIV/AIDS, trauma, and after surgery. General muscle growth and strength in healthy people isn't covered in the data we hold.
What if I have kidney or liver problems?
Use this supplement only under medical supervision if you have kidney or liver disease. Your doctor needs to monitor how your body handles it, so don't start without their okay.
Is glutamine a naturally occurring amino acid?
Yes — your body makes glutamine and uses it for muscle repair, immune function, and gut health. This supplement gives you a concentrated dose of that same amino acid.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Glutamine Muscle Support is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Glutamine Muscle Support label
Go deeper

The Full Monographs Behind Glutamine Muscle Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Glutamine Muscle Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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